Three Efficient All-Erasure Decoding Methods for Blaum-Roth Codes.

Blaum-Roth Codes are binary maximum distance separable (MDS) array codes over the binary quotient ring F2[x]/(Mp(x)), where Mp(x)=1+x+⋯+xp-1, and p is a prime number. Two existing all-erasure decoding methods for Blaum-Roth codes are the syndrome-based decoding method and the interpolation-based decoding method. In this paper, we propose a modified syndrome-based decoding method and a modified interpolation-based decoding method that have lower decoding complexity than the syndrome-based decoding method and the interpolation-based decoding method, respectively. Moreover, we present a fast decoding method for Blaum-Roth codes based on the LU decomposition of the Vandermonde matrix that has a lower decoding complexity than the two modified decoding methods for most of the parameters.

Using deep reinforcement learning to speed up collective cell migration.

BACKGROUND: Collective cell migration is a significant and complex phenomenon that affects many basic biological processes. The coordination between leader cell and follower cell affects the rate of collective cell migration. However, there are still very few papers on the impacts of the stimulus signal released by the leader on the follower. Tracking cell movement using 3D time-lapse microscopy images provides an unprecedented opportunity to systematically study and analyze collective cell migration. RESULTS: Recently, deep reinforcement learning algorithms have become very popular. In our paper, we also use this method to train the number of cells and control signals. By experimenting with single-follower cell and multi-follower cells, it is concluded that the number of stimulation signals is proportional to the rate of collective movement of the cells. Such research provides a more diverse approach and approach to studying biological problems. CONCLUSION: Traditional research methods are always based on real-life scenarios, but as the number of cells grows exponentially, the research process is too time consuming. Agent-based modeling is a robust framework that approximates cells to isotropic, elastic, and sticky objects. In this paper, an agent-based modeling framework is used to establish a simulation platform for simulating collective cell migration. The goal of the platform is to build a biomimetic environment to demonstrate the importance of stimuli between the leading and following cells.

Effective norm emergence in cell systems under limited communication.

BACKGROUND: The cooperation of cells in biological systems is similar to that of agents in cooperative multi-agent systems. Research findings in multi-agent systems literature can provide valuable inspirations to biological research. The well-coordinated states in cell systems can be viewed as desirable social norms in cooperative multi-agent systems. One important research question is how a norm can rapidly emerge with limited communication resources. RESULTS: In this work, we propose a learning approach which can trade off the agents' performance of coordinating on a consistent norm and the communication cost involved. During the learning process, the agents can dynamically adjust their coordination set according to their own observations and pick out the most crucial agents to coordinate with. In this way, our method significantly reduces the coordination dependence among agents. CONCLUSION: The experiment results show that our method can efficiently facilitate the social norm emergence among agents, and also scale well to large-scale populations.

Proteomic biomarkers for lung cancer progression.

AIM: Lung adenocarcinoma (LUAD) and lung squamous-cell carcinoma (LUSC) are two major subtypes of lung cancer and constitute about 70% of all the lung cancer cases. The patient's lifespan and living quality will be significantly improved if they are diagnosed at an early stage and adequately treated. METHODS & RESULTS: This study comprehensively screened the proteomic dataset of both LUAD and LUSC, and proposed classification models for the progression stages of LUAD and LUSC with accuracies 86.51 and 89.47%, respectively. DISCUSSION & CONCLUSION: A comparative analysis was also carried out on related transcriptomic datasets, which indicates that the proposed biomarkers provide discerning power for accurate stage prediction, and will be improved when larger-scale proteomic quantitative technologies become available.