Detalhe da pesquisa
1.
Phase 1 study to evaluate safety, tolerability and pharmacokinetics of a novel intra-tympanic administered thiosulfate to prevent cisplatin-induced hearing loss in cancer patients.
Invest New Drugs
; 38(5): 1463-1471, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32157599
2.
Small-molecule WNK inhibition regulates cardiovascular and renal function.
Nat Chem Biol
; 12(11): 896-898, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27595330
3.
Towards the next generation of biomedicines by site-selective conjugation.
Chem Soc Rev
; 45(6): 1691-719, 2016 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26796469
4.
Exploring the Effect of Conjugation Site and Chemistry on the Immunogenicity of an anti-Group B Streptococcus Glycoconjugate Vaccine Based on GBS67 Pilus Protein and Type V Polysaccharide.
Bioconjug Chem
; 26(8): 1839-49, 2015 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26230938
5.
Sugar-Protein Connectivity Impacts on the Immunogenicity of Site-Selective Salmonella O-Antigen Glycoconjugate Vaccines.
Angew Chem Int Ed Engl
; 54(45): 13198-203, 2015 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26350581
6.
Defined conjugation of glycans to the lysines of CRM197 guided by their reactivity mapping.
Chembiochem
; 15(6): 836-43, 2014 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616190
7.
Tyrosine-directed conjugation of large glycans to proteins via copper-free click chemistry.
Bioconjug Chem
; 25(12): 2105-11, 2014 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25415860
8.
New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap.
Proteins
; 78(12): 2571-86, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20589640
9.
Correction to Exploring the Effect of Conjugation Site and Chemistry on the Immunogenicity of an anti-Group B Streptococcus Glycoconjugate Vaccine Based on GBS67 Pilus Protein and Type V Polysaccharide.
Bioconjug Chem
; 26(10): 2167, 2015 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26355285
10.
Pharmacokinetics and tissue distribution of neurotrophin 3 after intracochlear delivery.
J Control Release
; 299: 53-63, 2019 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30790594
11.
Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.
Curr Top Med Chem
; 16(16): 1792-818, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26975508
12.
Anti-Group B Streptococcus Glycan-Conjugate Vaccines Using Pilus Protein GBS80 As Carrier and Antigen: Comparing Lysine and Tyrosine-directed Conjugation.
ACS Chem Biol
; 10(7): 1737-46, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25906283
13.
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
J Med Chem
; 58(11): 4749-70, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25953419
14.
Useful enantioselective bicyclization reactions using an N-protonated chiral oxazaborolidine as catalyst.
Org Lett
; 5(21): 3979-82, 2003 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-14535758
15.
Highly efficient chemical kinetic resolution of bishomoallylic alcohols: synthesis of (R)-sulcatol.
Org Lett
; 6(19): 3365-7, 2004 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15355053
16.
Stereocontrolled synthesis of linear 22R-homoallylic sterols via a triflic acid-catalyzed 2-oxonia Cope rearrangement.
Org Lett
; 4(14): 2389-91, 2002 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12098254
17.
The First In(OTf)3 -Catalyzed Conversion of Kinetically Formed Homoallylic Alcohols into the Thermodynamically Preferred Regioisomers: Application to the Synthesis of 22α-Sterols.
Angew Chem Int Ed Engl
; 40(15): 2921-2922, 2001 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29711997
18.
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
ACS Med Chem Lett
; 4(12): 1203-7, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900631
19.
The First In(OTf)(3)-Catalyzed Conversion of Kinetically Formed Homoallylic Alcohols into the Thermodynamically Preferred Regioisomers: Application to the Synthesis of 22alpha-Sterols This research was supported by the National University of Singapore.
Angew Chem Int Ed Engl
; 40(15): 2921-2922, 2001 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-11500910
20.
Application of chiral cationic catalysts to several classical syntheses of racemic natural products transforms them into highly enantioselective pathways.
J Am Chem Soc
; 126(42): 13708-13, 2004 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-15493929