Detalhe da pesquisa
1.
Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling.
Bioorg Chem
; 143: 107016, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38086239
2.
The progress of small molecules against cannabinoid 2 receptor (CB2R).
Bioorg Chem
; 144: 107075, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38218067
3.
Discovery of a potent and selective PARP1 degrader promoting cell cycle arrest via intercepting CDC25C-CDK1 axis for treating triple-negative breast cancer.
Bioorg Chem
; 142: 106952, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37952486
4.
Discovery of novel pyrrolo [2,3-d] pyrimidine derivatives as potent FAK inhibitors based on cyclization strategy.
Bioorg Chem
; 139: 106713, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37459823
5.
Discovery of potent and selective HPK1 inhibitors based on the 2,4-disubstituted pyrimidine scaffold with immune modulatory properties for ameliorating T cell exhaustion.
Bioorg Chem
; 139: 106728, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37536217
6.
A Novel Diagnosis Method Based on Methylation Analysis of SHOX2 and Serum Biomarker for Early Stage Lung Cancer.
Cancer Control
; 27(1): 1073274820969703, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33167712
7.
HZ-A-005, a potent, selective, and covalent Bruton's tyrosine kinase inhibitor in preclinical development.
Bioorg Chem
; 105: 104377, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33091668
8.
Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1).
J Enzyme Inhib Med Chem
; 35(1): 1606-1615, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32779949
9.
An Aseptic One-Shot Bottom-Up Method To Produce Progesterone Nanocrystals: Controlled Size and Improved Bioavailability.
Mol Pharm
; 16(12): 5076-5084, 2019 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31670968
10.
Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping.
J Enzyme Inhib Med Chem
; 34(1): 808-817, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30879350
11.
Antifibrotic effects of a novel pirfenidone derivative in vitro and in vivo.
Pulm Pharmacol Ther
; 53: 100-106, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30394340
12.
Butein Inhibited In Vitro Hexokinase-2-Mediated Tumor Glycolysis in Hepatocellular Carcinoma by Blocking Epidermal Growth Factor Receptor (EGFR).
Med Sci Monit
; 24: 3283-3292, 2018 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29777095
13.
On-line biofilm strength detection in cross-flow membrane filtration systems.
Biofouling
; 34(2): 123-131, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29268634
14.
Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca2+-permeable Cationic Channel in lung carcinoma cells.
Mol Cancer
; 16(1): 147, 2017 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28851360
15.
Evaluation of HE4 in the Diagnosis and Follow Up of Non-Small Cell Lung Cancers.
Clin Lab
; 63(3): 461-467, 2017 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28271686
16.
Three new alkaloids from Veratrum grandiflorum Loes with inhibition activities on Hedgehog pathway.
Bioorg Med Chem Lett
; 26(19): 4735-4738, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27567371
17.
Comparison of Borate Bioactive Glass and Calcium Sulfate as Implants for the Local Delivery of Teicoplanin in the Treatment of Methicillin-Resistant Staphylococcus aureus-Induced Osteomyelitis in a Rabbit Model.
Antimicrob Agents Chemother
; 59(12): 7571-80, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416858
18.
Discovery of Novel Selective ERα/ERß Ligands by Multi-pharmacophore Modeling and Virtual Screening.
Chem Pharm Bull (Tokyo)
; 63(10): 780-91, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26423034
19.
Synthesis and biological evaluation of the pirfenidone derivatives as antifibrotic agents.
Bioorg Med Chem Lett
; 24(1): 220-3, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24332090
20.
A novel injectable borate bioactive glass cement for local delivery of vancomycin to cure osteomyelitis and regenerate bone.
J Mater Sci Mater Med
; 25(3): 733-45, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24477872