Detalhe da pesquisa
1.
Oral Ritlecitinib and Brepocitinib for Moderate-to-Severe Ulcerative Colitis: Results From a Randomized, Phase 2b Study.
Clin Gastroenterol Hepatol
; 21(10): 2616-2628.e7, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36623678
2.
Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study.
Clin Gastroenterol Hepatol
; 19(11): 2324-2332.e6, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34126262
3.
First-in-human, randomized dose-escalation study of the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of PF-06480605 in healthy subjects.
Br J Clin Pharmacol
; 86(4): 812-824, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31758576
4.
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Nature
; 491(7423): 254-8, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23034650
5.
In vivo wide-area cellular imaging by side-view endomicroscopy.
Nat Methods
; 7(4): 303-5, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20228814
6.
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.
Proc Natl Acad Sci U S A
; 107(4): 1565-70, 2010 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080688
7.
Baseline serum and stool microbiome biomarkers predict clinical efficacy and tissue molecular response after ritlecitinib induction therapy in ulcerative colitis.
J Crohns Colitis
; 2023 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38141256
8.
In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer.
Mol Imaging
; 11(5): 417-25, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22954186
9.
Antitumor Necrosis Factor-like Ligand 1A Therapy Targets Tissue Inflammation and Fibrosis Pathways and Reduces Gut Pathobionts in Ulcerative Colitis.
Inflamm Bowel Dis
; 28(3): 434-446, 2022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34427649
10.
PKM2 is not required for colon cancer initiated by APC loss.
Cancer Metab
; 5: 10, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29214019
11.
Proteomic approaches to cancer biomarkers.
Gastroenterology
; 138(1): 46-51.e1, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19931265
12.
New insights into the molecular pathogenesis of colorectal cancer.
Drug Discov Today Dis Mech
; 3(4): 439, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-20151020
13.
Detection of proximal adenomatous polyps with screening sigmoidoscopy: a systematic review and meta-analysis of screening colonoscopy.
Arch Intern Med
; 163(4): 413-20, 2003 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12588199
14.
Overview of genetically engineered mouse models of colorectal carcinoma to enable translational biology and drug development.
Curr Protoc Pharmacol
; 65: 14.29.1-10, 2014 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24934606
15.
Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras.
Cancer Lett
; 347(2): 191-5, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24632531
16.
Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
Cancer Lett
; 347(2): 204-11, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24576621
17.
Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.
Dis Model Mech
; 7(6): 613-23, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24742783
18.
Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.
Sci Signal
; 7(351): ra107, 2014 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25389372
19.
Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture.
Nat Med
; 20(7): 769-77, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24859528
20.
mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
Cancer Discov
; 4(1): 42-52, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24163374