Detalhe da pesquisa
1.
Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc Natl Acad Sci U S A
; 121(15): e2317274121, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38579010
2.
Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.
Mol Cell
; 70(1): 83-94.e7, 2018 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29625040
3.
Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections.
Proc Natl Acad Sci U S A
; 118(10)2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33649203
4.
Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria.
Mol Biol Evol
; 39(4)2022 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35348727
5.
Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene.
Proc Natl Acad Sci U S A
; 117(6): 3185-3191, 2020 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31992637
6.
Genetic Architecture and Fitness of Bacterial Interspecies Hybrids.
Mol Biol Evol
; 38(4): 1472-1481, 2021 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33247724
7.
Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli.
Mol Biol Evol
; 37(6): 1637-1646, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32031639
8.
Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins.
J Antimicrob Chemother
; 76(6): 1441-1447, 2021 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33655294
9.
Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli.
J Antimicrob Chemother
; 76(1): 77-83, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33089314
10.
Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response.
J Antimicrob Chemother
; 76(3): 606-615, 2021 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33221850
11.
Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues.
Bioorg Med Chem
; 28(11): 115469, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32279921
12.
In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.
J Antimicrob Chemother
; 74(4): 944-952, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30629184
13.
Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli.
Mol Biol Evol
; 34(5): 1029-1039, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28087782
14.
Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli.
J Antimicrob Chemother
; 73(12): 3285-3292, 2018 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30239743
15.
Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli.
J Antimicrob Chemother
; 72(11): 3016-3024, 2017 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28962020
16.
Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects.
J Antimicrob Chemother
; 72(1): 75-84, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27621175
17.
Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).
Bioorg Med Chem
; 25(3): 897-911, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28038943
18.
Gut inflammation provides a respiratory electron acceptor for Salmonella.
Nature
; 467(7314): 426-9, 2010 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20864996
19.
Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota.
Proc Natl Acad Sci U S A
; 108(42): 17480-5, 2011 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21969563
20.
Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine blood stream infection models.
Int J Antimicrob Agents
; : 107181, 2024 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38653351