RESUMO
Staphylococcus lugdunensis (SL) is a well-known skin commensal. It is coagulase-negative bacteria that has often been labeled as a contaminant. While coagulase-negative bacteria are not as virulent as Staphylococcus aureus, there has been an increasing trend for this organism to be associated with complications commonly known to occur with its more aggressive counterpart. We report a case of Staphylococcus lugdunensis causing infective endocarditis and pseudoaneurysm of the aorta.
RESUMO
The Pd-catalyzed Suzuki-Miyaura coupling reaction of unsymmetric 1,3-disubstituted secondary allylic carbonates with arylboronic acids has been developed in a wet solvent under a base-free system to afford allyl-aryl coupling products in a high level of isolated yields with complete regio- and E/Z-selectivities with good to excellent chemoselectivities. The coupling reaction of optically active allyl carbonates gave allyl-aryl coupling products with excellent enantioselectivities with inversion of the stereochemistry. This coupling method was successfully applied to the synthesis of (S)-naproxen.