Detalhe da pesquisa
1.
Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP.
Biochemistry
; 58(16): 2133-2143, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30924641
2.
Enzyme-catalyzed expressed protein ligation.
Nat Methods
; 13(11): 925-927, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27669326
3.
Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action.
J Am Chem Soc
; 140(30): 9478-9485, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29991262
4.
Mechanistic analysis of ghrelin-O-acyltransferase using substrate analogs.
Bioorg Chem
; 62: 64-73, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26246082
5.
Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase.
J Biol Chem
; 288(45): 32211-32228, 2013 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24045953
6.
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator.
Nature
; 451(7180): 846-50, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18273021
7.
Inhibition of ghrelin O-acyltransferase attenuates food deprivation-induced increases in ingestive behavior.
Horm Behav
; 63(4): 667-73, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23399323
8.
Electrophilic tuning of the chemoprotective natural product sulforaphane.
Proc Natl Acad Sci U S A
; 107(21): 9590-5, 2010 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20439747
9.
Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice.
J Clin Invest
; 133(13)2023 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37227777
10.
NMR as a readout to monitor and restore the integrity of complex chemoenzymatic reactions.
J Magn Reson
; 342: 107265, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35849973
11.
HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy.
J Clin Invest
; 132(9)2022 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35499076
12.
Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.
J Am Chem Soc
; 132(29): 9986-7, 2010 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20608637
13.
CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers.
Mol Cell Biol
; 39(17)2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182641
14.
Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride.
Org Lett
; 6(10): 1555-6, 2004 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15128234
15.
A selective chemical probe for coenzyme A-requiring enzymes.
Angew Chem Int Ed Engl
; 46(40): 7621-4, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17768748
16.
Ghrelin O-acyltransferase assays and inhibition.
Methods Enzymol
; 514: 205-28, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22975055
17.
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor.
Science
; 330(6011): 1689-92, 2010 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21097901
18.
Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug.
Bioorg Med Chem
; 15(5): 2147-55, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17258461