Detalhe da pesquisa
1.
TERT activation targets DNA methylation and multiple aging hallmarks.
Cell
; 2024 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38908367
2.
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.
Proc Natl Acad Sci U S A
; 120(20): e2300763120, 2023 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37155889
3.
YAP-dependent proliferation by a small molecule targeting annexin A2.
Nat Chem Biol
; 17(7): 767-775, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33723431
4.
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators.
Bioorg Med Chem Lett
; 89: 129306, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37116763
5.
Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators.
Bioorg Chem
; 108: 104614, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33508678
6.
2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles.
J Am Chem Soc
; 142(19): 8972-8979, 2020 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302104
7.
Small-Molecule Stimulators of NRF1 Transcriptional Activity.
Chembiochem
; 21(13): 1816-1819, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31596542
8.
HDAC6 Modulates Signaling Pathways Relevant to Synaptic Biology and Neuronal Differentiation in Human Stem-Cell-Derived Neurons.
Int J Mol Sci
; 20(7)2019 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30935091
9.
Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines.
J Proteome Res
; 16(2): 481-493, 2017 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28152600
10.
Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells.
Mol Cell Neurosci
; 73: 96-103, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26777134
11.
Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells.
ACS Chem Biol
; 12(8): 2139-2148, 2017 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28628306
12.
Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.
Mol Neuropsychiatry
; 2(2): 97-106, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27606323
13.
HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of ß-catenin in human iPSC-derived neuronal cells.
ACS Chem Biol
; 10(3): 883-90, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25546293
14.
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
Cell Rep
; 10(5): 755-770, 2015 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25660025