RESUMO
With this study, the Authors, have demonstrated that atropine has an inhibiting action on the hypophysis response and that such inhibition is correlated to the length of time between the i.m. injection of anticholinergic and the intravenous administration of TRH. Such results make believe that in human, as in the animal the cholinergic system plays a role, maybe important, in the prolactin release.
Assuntos
Atropina/farmacologia , Prolactina/sangue , Hormônio Liberador de Tireotropina/farmacologia , Adulto , Feminino , Humanos , Masculino , Sistema Nervoso ParassimpáticoAssuntos
Adenocarcinoma/diagnóstico , Neoplasias da Próstata/diagnóstico , Fosfatase Ácida/sangue , Adenocarcinoma/patologia , Idoso , Antígenos de Neoplasias/análise , Cálculos/diagnóstico , Ensaios Enzimáticos Clínicos , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Próstata/enzimologia , Antígeno Prostático Específico , Hiperplasia Prostática/diagnóstico , Neoplasias da Próstata/patologia , Fatores de TempoAssuntos
Infecções por HIV/transmissão , HIV-1 , Hepatite B/transmissão , Hepatite C/transmissão , Hepatite D/transmissão , Prisioneiros , Adulto , Idoso , Infecções por HIV/epidemiologia , Hepatite B/epidemiologia , Hepatite C/epidemiologia , Hepatite D/epidemiologia , Dependência de Heroína/complicações , Homossexualidade , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Prisioneiros/estatística & dados numéricos , Fatores de Risco , Estudos SoroepidemiológicosRESUMO
The AA. have tested 50 serum samples for immunoglobulins (IgG, IgA, IgM) with two different methods: laser-nephelometry (LN) and radial immunodiffusion (RID). Mean values of IgG and IgA are almost the same in the two tested methods and there is a good correlation between LN and RID (IgG: r = 0,98; IgA: = 0,96). Also IgM have showed a good correlation (r = 0,987) but mean values obtained with LN are just a few lower than those obtained with RID. Regression lines, calculated for all the Ig, confirm these conclusions. The AA. conclude affirming that the obtained difference for IgM is due to the different standards used for LN and RID determinations.
Assuntos
Imunoglobulina A/análise , Imunoglobulina G/análise , Imunoglobulina M/análise , Humanos , Imunodifusão , Lasers , Nefelometria e TurbidimetriaRESUMO
The Authors have tested serum levels of CEA, ferritin, Alpha-1-antitrypsin, parathyroid hormone (PTH) and calcitonin (CT) in 286 patients affected by lung, gastrointestinal, breast and other kinds of cancer and by non neoplastic diseases. 50 healthy subjects were tested as matched controls too. None of the tested patients was subjected to blood transfusion, therapy with iron, radio- or chemotherapy before the blood drawing. Cea, ferritin, PTH and CT were tested by radioimmunoassay; AAT by laser nephelometry. All the healthy subjects showed serum levels of the markers in the normal ranges. Also the percent of cases with contemporaneous pathological markers was examined. The obtained data have been statistically controlled with "chi square" test. The results show that CEA, ferritin, AAT and CT are higher in the tumor groups than in the others. On the contrary PTH seems to be not useful as tumor marker. The Authors conclude affirming that it is not possible to use any of the tested substances as a specific tumor marker but it is useful to test at the same time these markers in the patients suspected to be affected by cancer for an early diagnosis and therapy, as there are few false positive and false negative cases.
Assuntos
Calcitonina/sangue , Antígeno Carcinoembrionário/análise , Ferritinas/sangue , Neoplasias/diagnóstico , Hormônio Paratireóideo/sangue , alfa 1-Antitripsina/análise , Adulto , Idoso , Neoplasias da Mama/sangue , Neoplasias da Mama/diagnóstico , Feminino , Neoplasias Gastrointestinais/sangue , Neoplasias Gastrointestinais/diagnóstico , Humanos , Pneumopatias Obstrutivas/sangue , Pneumopatias Obstrutivas/diagnóstico , Neoplasias Pulmonares/sangue , Neoplasias Pulmonares/diagnóstico , Masculino , Pessoa de Meia-Idade , Neoplasias/sangueRESUMO
The authors have tested serum levels of cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol, with the plasmatic levels of Antithrombin III and other parameters (Quick time, PTT, fibrinogenaemia and platelets) in patients affected by chronic obstructive arterious diseases in various stages including a group of patients affected by diabetes mellitus. The results show that there is a correlation between the behaviour of the parameter tested and the follow-up of the diseases, particularly for HDL and LDL cholesterol and Antithrombin III. The authors suggest the use of these tests for monitoring this kind of vascular peripheral diseases.
Assuntos
Antitrombina III/análise , Arteriopatias Oclusivas/sangue , Fibrinogênio/análise , Lipídeos/sangue , Adulto , Idoso , Doença Crônica , Diabetes Mellitus Tipo 2/sangue , Angiopatias Diabéticas/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Trombocitose/sangueRESUMO
The AA. have tested serum levels of ferritin, alpha-1-antitripsyn, C4 and Phosphohexoseisomerase (PHI) in 50 patients affected by primary lung cancer, 40 patients affected by chronic lung diseases and a control group of 40 healthy males and females. All the test have a percentage of pathological case higher in the group of neoplasms than in the group of chronic diseases and ferritin seems to have the highest sensitivity. Obtained results have been correlated also to the morphoradiological and histological kind of neoplasm. "Peripheral" morphoradiological kind and III WHO histological kind are the group with more pathological cases. All the data have been statistically controlled.
Assuntos
Complemento C4/análise , Ferritinas/análise , Glucose-6-Fosfato Isomerase/sangue , Neoplasias Pulmonares/sangue , alfa 1-Antitripsina/análise , Adulto , Idoso , Doença Crônica , Feminino , Humanos , Pneumopatias/sangue , Masculino , Pessoa de Meia-IdadeRESUMO
The Authors have tested serum levels of LH and FSH in 10 healthy males after stimulation test with GnRH preceded by administration i.m. of 1 mg. of atropine 10' and 1 hour before the test, to examine some interferences of the drug on ipophisary gonadotropins. Atropine has no effect on LH and FSH release because there are no differences between mean values of the hormones during the test with and without atropine, at any time it is administered. All the data obtained have been controlled with Student's "t" test.
Assuntos
Atropina , Hormônio Foliculoestimulante/sangue , Hormônio Liberador de Gonadotropina , Hormônio Luteinizante/sangue , Adulto , Humanos , Masculino , Valores de ReferênciaRESUMO
The Authors have tested serum levels of PRL and TSH in six healthy males, anaesthesized with 20 mg./Kg. body weight of pentobarbital with and without stimultion with TRH. PB has no effect on serum levels of TSH but there is an inhibition of PRL release 180', 240' and 360' after the administration of the drug. The AA. have found no effects of PB on the stimulation test with TRH. All the data obtained have been examined with Student's "T" test.
Assuntos
Pentobarbital/farmacologia , Prolactina/sangue , Hormônio Liberador de Tireotropina , Tireotropina/sangue , Adulto , Atropina/farmacologia , Humanos , Cinética , Masculino , Valores de ReferênciaRESUMO
The authors tested 366 samples for the detection of HBcAb using enzyme-linked immunosorbent assay (ELISA) and radioimmuno assay (RIA). Twenty samples were titered to compare the sensitivity of the two tests. The results showed that the two methods gave very similar results, with only a few doubtful cases for RIA. ELISA seems to be more sensitive than RIA for the titration of the positive samples. The authors conclude that the ELISA method is easier than RIA and does not require any apparatus in particular.
Assuntos
Anticorpos Antivirais/análise , Portador Sadio/diagnóstico , Ensaio de Imunoadsorção Enzimática , Anticorpos Anti-Hepatite B/análise , Hepatite B/diagnóstico , Técnicas Imunoenzimáticas , Radioimunoensaio , Hepatite B/imunologia , Antígenos do Núcleo do Vírus da Hepatite B/imunologia , HumanosRESUMO
The effect of anaesthesia with atropine and pentobarbital (PB) in three groups of volunteers has been tested. The dose used for the anaesthesia was 20 mg/kg body weight of PB. The experiment was performed with and without stimulation test with GnRH. Anaesthesia was shown to increase serum levels of LH and to increase the response to stimulation with GnRH. Atropine and mental stress seem to have no effect on the hormones. No variation in serum levels of FSH in the anaesthesized volunteers was noted. The data obtained have been statistically controlled.
Assuntos
Anestesia Geral , Hormônio Foliculoestimulante/sangue , Hormônio Luteinizante/sangue , Hormônios Liberadores de Hormônios Hipofisários/farmacologia , Adulto , Atropina/farmacologia , Humanos , Masculino , Pentobarbital/farmacologiaRESUMO
The Authors have tested serum levels of alpha-1-antitrypsin (A1AT), phosphohexose-isomerase (GPI) and carcinoembryonic antigen (CEA) in 133 patients affected with primary lung cancer, not treated with any drug, and in 183 patients affected with not neoplastic lung diseases or healthy, to control the utility of these markers in the early diagnosis of lung cancer. In many patients all the tests have been made at the same time. The three tumoral markers have been also examined in connection with the histological kinds of lung cancer. Results show that is suitable to test GIP and A1AT at the same time because they are percentually more pathological; serum levels of CEA, that are not very elevated in the pathological cases, seem in correlation with the histological kind of cancer.