1.
Bioorg Chem
; 62: 8-14, 2015 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26159895
RESUMO
A tetrapeptide, l-histidyl-glycyl-glycyl-l-histidine (HGGH), was synthesized and the pUC19 plasmid DNA cleaving activity by copper(II) complex of HGGH (Cu(II)-HGGH) was investigated. Cu(II)-HGGH showed bleomycin-like DNA cleaving activity and, at 50nM, converted a supercoiled DNA efficiently to a linear DNA in the presence of 500µM H2O2/sodium ascorbate through an oxidative pathway.