Detalhe da pesquisa
1.
Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor.
Gynecol Oncol
; 172: 65-71, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36958197
2.
Discovery of Novel 7-[(1R,5S)-1-Amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropane]-8-(methoxy or methyl)quinolones.
Chem Pharm Bull (Tokyo)
; 67(1): 47-58, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30606950
3.
Two distinct EF-Tu epitopes induce immune responses in rice and Arabidopsis.
Mol Plant Microbe Interact
; 27(2): 113-24, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24200076
4.
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.
Bioorg Med Chem
; 17(19): 6879-89, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19736016
5.
Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.
ACS Med Chem Lett
; 10(5): 737-742, 2019 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31097992
6.
Design, Synthesis, and Biological Evaluation of Novel 7-[(3 aS,7 aS)-3 a-Aminohexahydropyrano[3,4- c]pyrrol-2(3 H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens.
J Med Chem
; 61(16): 7234-7244, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30063826
7.
Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode.
J Med Chem
; 50(11): 2693-9, 2007 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-17469812
8.
Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents.
J Med Chem
; 46(6): 1005-15, 2003 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12620077
9.
Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens.
J Med Chem
; 56(5): 1974-83, 2013 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23409972
10.
Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position.
Bioorg Med Chem Lett
; 14(20): 5193-8, 2004 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380226