RESUMO
This study reports on the use of a new transdermal delivery system for estrogen replacement therapy. This was a 12 week open multicenter trial using patches that delivered 0.05 mg/24 hour of 17 beta-estradiol applied twice weekly, every 72 hours, with one week interval after each 3 weeks. Results indicate an overall significant improvement on climacteric complaints with a highly significant and time-related reduction in the two most frequent symptoms: hot flushes and night sweating. Neither local nor systemic side effects were prevalent. By the end of treatment mean plasma levels of estradiol and FSH were 50.6 pg/ml and 46.8 mIU/ml, respectively. It is concluded that this new system of transdermal estrogen replacement therapy significantly reduces the main postmenopausal symptoms, produces adequate plasma estradiol levels and allows good compliance to treatment.
Assuntos
Climatério/efeitos dos fármacos , Estradiol/administração & dosagem , Terapia de Reposição de Estrogênios , Menopausa/efeitos dos fármacos , Administração Cutânea , Esquema de Medicação , Estradiol/efeitos adversos , Estradiol/sangue , Feminino , Hormônio Foliculoestimulante/sangue , Humanos , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
Optimal conditions of pH, dose, time and temperature for the in vitro uptake of radioactivity from 3-H-E or 3-H-NE by the human endometrium and myometrium were established. Uptake was dependent on temperature but not on pH. Uptake of radioactivity from 3-H-NE was always higher (p smaller than 0.05) in both tissues than the uptake of radioactivity from 3-H-E at all the studied times but 10 minutes. Only the uptake of radioactivity from 3-H-NE by the myometrium increased continuously from 2 to 90 minutes. E2 increased the uptake of radioactivity from 3-H-E and decreased the one from 3-H-NE, being both effects more significant (p smaller than 0.05) in the myometrium. Both E and NE increased significantly (p smaller than 0.05) the uptake of 3-H-E2 by the myometrium but not by the endometrium. These results indicate that the interactions between E and NE and E2 are more marked in the myometrium. The uterine tissues studied corresponded to the secretory phase of the menstrual cycle, which was established by the endometrial histology and plasma levels of progesterone.