Histologic Severity of Nonalcoholic Fatty Liver Disease Associates with Reduced Bone Mineral Density in Children.

BACKGROUND: Lower whole body bone mineral density (BMD) has been reported in children with nonalcoholic fatty liver disease (NAFLD), but potential mediators remain uncertain. AIMS: To assess BMD at multiple skeletal sites in children with confirmed NAFLD and controls with obesity, adjusting for known determinants of BMD, and examine potential mediators. METHODS: We assessed age-, sex-, and race-specific, and height-adjusted BMD z-scores of whole body, lumbar spine, hip, femoral neck and forearm by dual-energy-x-ray absorptiometry in 79 children, 8-19 years old: 46 with biopsy-confirmed NAFLD [29 steatohepatitis (NASH)/17 fatty liver (NAFL)] and 33 controls without liver disease. We compared BMD z-scores by multivariable regression, adjusting for known BMD determinants and potential mediators (inflammatory and insulin resistance measures). RESULTS: Unadjusted mean BMD z-scores in NAFLD were similar to controls, but significantly lower in NASH vs. NAFL at all sites. After covariate adjustment, mean forearm BMD z-score was higher in NAFL (ß 0.60 ± SE 0.30, p < 0.05) and lower in NASH (ß - 0.49 ± SE 0.26, p = 0.06) vs. controls (p = 0.002 for group), with similar trends at whole body and total hip; hs-CRP negatively associated with whole body and forearm BMD z-scores (p < 0.05), while visceral fat area negatively associated with femoral neck (p < 0.05). Only three children had clinically low whole body BMD z-scores (< - 2), one per group (control, NAFL and NASH). CONCLUSIONS: NASH, but not NAFL, may be associated with increased risk of reduced BMD in children. Systemic inflammation, independent of body composition and load bearing, may mediate reduction in BMD in NASH.

Cardiovascular impact of the pediatric obesity epidemic: higher left ventricular mass is related to higher body mass index.

OBJECTIVE: To compare secular changes in body mass index (BMI) and left ventricular mass (LVM) in today's children versus children of a generation earlier. STUDY DESIGN: All healthy patients aged 2 to 19 years who underwent echocardiography at a single US academic medical center in 1986 to 1989 (prior era) and 2008 (current era) were included in this retrospective cross-sectional study. BMI, BMI z score, LVM indexed to height (LVMI), LVM z score, and relative wall thickness were calculated. Cardiac geometries were assigned based on LVM z score and relative wall thickness and classified as normal, concentric hypertrophy, eccentric hypertrophy, or concentric remodeling. Stepwise regression analysis was performed to identify determinants of LVMI. RESULTS: There were 350 subjects in the prior era and 350 age- and sex-matched subjects in the current era. Mean BMI and LVMI were both significantly higher in the current era than in the prior era (BMI, 19.9 ± 5.6 kg/m(2) vs 18.1 ± 3.8 kg/m(2), P = .0004; LVMI, 32.7 ± 7.8 g/m(2.7) vs 31.5 ± 8.1 g/m(2.7); P = .02). Determinants of LVMI in both eras were BMI z score, younger age, male sex, and African-American race. CONCLUSIONS: Today's children have higher BMI, LVMI, and predicted cardiovascular risk than their counterparts a generation earlier. Reversal of these trends is needed, and intervention is required.

Hypertriglyceridemia Induced Pancreatitis: Inpatient Management at a Single Pediatric Institution.

OBJECTIVES: Hypertriglyceridemia-induced pancreatitis is an important cause of acute pancreatitis (AP) in children, which lacks established guidelines. The aim of this study was to review management approaches at a single pediatric center. METHODS: This retrospective study included all inpatients younger than 21 years with AP and triglycerides (TG) of 1000 mg/dL or greater. A linear mixed effect model was used to calculate drop in TGs. The patient's diet, intravenous fluid (IVF) rate, insulin, and plasmapheresis were included in the model. RESULTS: Seventeen admissions were identified among 8 patients, average age 15 years (range, 6-19 years). Fifty percent had recurrent AP and 29% of admissions had complications including 1 death. The population was primarily female (75%), white (75%), and overweight, and 63% had diabetes. The median stay was 5.4 days. There were 14 approaches used with variations in IVF rates, insulin, plasmapheresis, and nill per os (NPO) versus feeds. Variables that reduced TG's were NPO, higher IVF rates, plasmapheresis, and insulin (P < 0.05). Importantly, NPO reduced TGs faster than those who started early nutrition. CONCLUSIONS: Hypertriglyceridemia is an important cause of pancreatitis in children. This study shares a management algorithm from a single institution. Larger studies are needed for more evidence-based guidelines.

Anomalous origin of the right coronary artery from the left ventricle.

A 22-month-old boy was referred to pediatric cardiology for evaluation of a heart murmur. He was asymptomatic except for occasional wheezing with activity. On evaluation, he was found to have both systolic and diastolic murmurs. Electrocardiography demonstrated possible left ventricular hypertrophy, with no evidence of ST-segment abnormalities. Echocardiography and cardiac catheterization showed an anomalous origin of the patient's right coronary artery from his left ventricle, just inferior to his aortic valve annulus.

Reversibility of cardiac abnormalities in morbidly obese adolescents.

OBJECTIVES: The purpose of this study was to evaluate changes in cardiac geometry, systolic and diastolic function before and after weight loss in morbidly obese adolescents. BACKGROUND: Cardiac abnormalities are present in morbidly obese adolescents; however, it is unclear if they are reversible with weight loss. METHODS: Data from 38 adolescents (13 to 19 years; 29 females, 9 males, 33 Caucasians, 5 African Americans) were evaluated before and after bariatric surgery. Left ventricular mass (LVM), left ventricular (LV) geometry, systolic and diastolic function were assessed by echocardiography. Mean follow up was 10 +/- 3 months. RESULTS: Weight and body mass index decreased post-operatively (mean weight loss 59 +/- 15 kg, pre-operative body mass index 60 +/- 9 kg/m(2) vs. follow-up 40 +/- 8 kg/m(2), p < 0.0001). Change in LVM index (54 +/- 13 g/m(2.7) to 42 +/- 10 g/m(2.7), p < 0.0001) correlated with weight loss (r = 0.41, p = 0.01). Prevalence of concentric left ventricular hypertrophy (LVH) improved from 28% at pre-operative to only 3% at follow up (p = 0.007), and normal LV geometry improved from 36% to 79% at follow up (p = 0.009). Diastolic function also improved (mitral E/Ea lateral 7.7 +/- 2.3 at pre-operative vs. 6.3 +/- 1.6 at post-operative, p = 0.003). In addition, rate-pressure product improved suggesting decreased cardiac workload (p < 0.001). CONCLUSIONS: Elevated LVM index, concentric LVH, altered diastolic function, and cardiac workload significantly improve following surgically induced weight loss in morbidly obese adolescents. Large weight loss due to bariatric surgery improves predictors of future cardiovascular morbidity in these young people.

The impact of evolving hand-carried echocardiographic technology on outpatient physical examination accuracy in pediatric cardiology.

BACKGROUND: Cardiac auscultory skills are declining. Hand-carried ultrasound (HCU) has been proposed as a method to enhance diagnostic accuracy of the physical examination (PE). However, features of HCU devices are varied. OBJECTIVE: The aim of this study was to compare the diagnostic accuracies of an experienced pediatric cardiac PE alone vs. the PE combined with the assistance of an HCU device when using 2 HCU devices with different capabilities. The results were compared with conventional echo as the reference standard. METHODS: All outpatients seen by a single pediatric cardiologist underwent physical examination and HCU. Two HCU devices were compared. The first HCU device (HCU-1) had limited options with only 2-dimensional echo, limited Doppler, and a single transducer frequency (2.5 MHz). The second HCU device (HCU-2) was a unit with greater transducer choices and a wider variety of applications. A single echocardiologist performed the PEs & HCUs. Conventional echoes were performed by a pediatric sonographer and interpreted by a second pediatric echocardiologist. Examination accuracies centered on 3 broad areas including: cardiac shunts, valvular insufficiency, and valvular anatomy. The accuracy of the PE alone was compared with the accuracy of the combined PE & HCU-1 vs. PE & HCU-2. RESULTS: Thirty patients total (3 months-19 years, 4-82 kg) were evaluated. Eighteen were examined with HCU-1 and 12 were examined with HCU-2. The accuracy of the combined PE & HCU-1 did not improve accuracy over the PE alone. However, the accuracy of the combined PE & HCU-2 was greater than the PE alone. CONCLUSIONS: Use of a limited HCU device does not improve diagnostic accuracy over an experienced PE alone and may actually worsen diagnostic accuracy in some cases. However, the improvements in newer HCU devices may enhance diagnostic accuracy over the PE alone, even for experienced physicians.

Implementation of an objective testing system in noninvasive cardiac imaging for evaluation of pediatric cardiology fellows.

INTRODUCTION: Current evaluation of pediatric cardiology fellow performance is subjective and qualitative. More objective tools are recommended by credentialing boards and may provide more effective evaluation and education. OBJECTIVE: A series of training level-specific multiple-choice tests were developed and evaluated for their effectiveness as evaluation and educational tools for pediatric cardiology fellows. METHODS: Imaging tests were created by 3 attending physicians and one sonographer with combined expertise in echocardiography, cardiac magnetic resonance imaging, and cardiac computed tomography. Test content was derived from educational materials, textbooks, journal articles, and lectures previously given to the fellows. The tests were computerized and installed on the hospital intranet. After completion of each test, a posttest session was conducted between the fellow and the director of echocardiography to review concepts surrounding incorrect answers. A survey of the test use was then completed by each fellow. RESULTS: Four progressively more difficult tests corresponding to each 1-month image rotation and an advanced fifth test for fellows intending to subspecialize in noninvasive cardiac imaging were created. Fifteen fellows took 39 tests (test 1, 15 fellows; test 2, 9 fellows; test 3, 9 fellows; test 4, 4 fellows; and test 5, 2 fellows). The difficulty level of the tests was similar relative to fellow academic level. The majority of fellows welcomed more objective data provided by the tests and 93% of the fellows stated the posttest session was educational. CONCLUSION: Implementation of a fellow testing system using training level-specific computerized questions and images provides objective data for fellow performance evaluations and is a unique and beneficial educational tool.