Detalhe da pesquisa
1.
Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions.
Proc Natl Acad Sci U S A
; 121(8): e2314914121, 2024 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346202
2.
Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function.
Proc Natl Acad Sci U S A
; 120(23): e2221244120, 2023 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37252999
3.
Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle.
Circ Res
; 133(5): 430-443, 2023 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37470183
4.
Molecular basis of force-pCa relation in MYL2 cardiomyopathy mice: Role of the super-relaxed state of myosin.
Proc Natl Acad Sci U S A
; 119(8)2022 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35177471
5.
Differences in thick filament activation in fast rodent skeletal muscle and slow porcine cardiac muscle.
J Physiol
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38695322
6.
Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension.
Circulation
; 147(25): 1919-1932, 2023 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37194598
7.
The myosin II coiled-coil domain atomic structure in its native environment.
Proc Natl Acad Sci U S A
; 118(14)2021 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33782130
8.
Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2.
Int J Mol Sci
; 24(19)2023 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37834023
9.
Thick filament activation is different in fast- and slow-twitch skeletal muscle.
J Physiol
; 600(24): 5247-5266, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36342015
10.
Frustration and folding of a TIM barrel protein.
Proc Natl Acad Sci U S A
; 116(33): 16378-16383, 2019 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31346089
11.
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin.
Proc Natl Acad Sci U S A
; 116(23): 11502-11507, 2019 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31110001
12.
Small Angle X-ray Diffraction as a Tool for Structural Characterization of Muscle Disease.
Int J Mol Sci
; 23(6)2022 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35328477
13.
MgADP Promotes Myosin Head Movement toward Actin at Low [Ca2+] to Increase Force Production and Ca2+-Sensitivity of Contraction in Permeabilized Porcine Myocardial Strips.
Int J Mol Sci
; 23(23)2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36499408
14.
A mechanism for sarcomere breathing: volume change and advective flow within the myofilament lattice.
Biophys J
; 120(18): 4079-4090, 2021 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34384761
15.
Titin-Based Force Modulates Cardiac Thick and Thin Filaments.
Circ Res
; 134(8): 1026-1028, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38482667
16.
Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle.
Proc Natl Acad Sci U S A
; 115(41): 10369-10374, 2018 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249654
17.
Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice.
Proc Natl Acad Sci U S A
; 115(10): E2338-E2347, 2018 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29463717
18.
Deciphering the super relaxed state of human ß-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.
Proc Natl Acad Sci U S A
; 115(35): E8143-E8152, 2018 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104387
19.
Effect of Active Lengthening and Shortening on Small-Angle X-ray Reflections in Skinned Skeletal Muscle Fibres.
Int J Mol Sci
; 22(16)2021 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34445232
20.
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.
FASEB J
; 33(3): 3152-3166, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30365366