Novel synthesis of gem-dichloroaziridines from imines via the KF/Al2O3-promoted generation of dichlorocarbene from chloroform.

KF/Al(2)O(3) was found to be an efficient base for the reaction of imines with chloroform in acetonitrile to give gem-dichloroaziridines 2 in moderate to high yields. The KF/Al(2)O(3)-promoted dichloroaziridination can be carried out with simple workup, tolerates a variety of functional groups present in the imines, and proceeds smoothly with a smaller amount of carbene source.

Potential insulinominetic agents of zinc(II) complexes with picolinamide derivatives: preparations of complexes, in vitro and in vivo studies.

Following the finding of in vitro insulinominetic activities of new prepared Zn(II) complexes with amide ligands (2-picolinamide (pa-a) and 6-methyl-2-picolinmethylamide (6mpa-ma)) in isolated rat adipocytes treated with epinephrine in terms of inhibition of free fatty acid release, their blood glucose normalizing effects were observed on daily intraperitoneal injections for 14 d in a type 2 diabetes mellitus model animal, KK-Ay mice. The blood glucose levels of KK-Ay mice were maintained in a normal range during the administration of both complexes. After the administration of each complex for 14 d, the improvement of glucose metabolism was confirmed as judged by the glucose tolerance test.