Acute Hepatitis in Infections Caused by Dengue Virus in Southern Punjab, Pakistan.

Background Dengue is the most common vector-borne disease worldwide. It poses a significant health burden in tropical and subtropical countries. Common clinical presentations include retro-orbital pain, fever, headache, nausea, vomiting and aches and pains in the body. A severe form of dengue fever is known as dengue hemorrhagic fever (DHF) that includes signs of hemorrhage. Besides the typical signs and symptoms, atypical presentations of dengue include myositis, hepatitis and encephalitis. Hepatic involvement in dengue has varied presentations. This study aims to highlight the importance of acute hepatitis, an atypical presentation in dengue patients. Methods  We conducted a descriptive, cross-sectional study in the Medical Unit-1 of Bahawal Victoria Hospital, Bahawalpur, a tertiary-care hospital serving the area of Southern Punjab, Pakistan. The relevant medical records of 63 patients admitted with dengue-associated hepatitis to the Medical Unit-1 of Bahawal Victoria Hospital, Bahawalpur, between January 1, 2015 and December 1, 2016, were reviewed. Informed consent was given. Information regarding demographic variables and disease course was collected and analyzed. Results  This study included 55 men (87.3%) and eight (12.7%) women. Fifty (79.3%) patients were diagnosed with dengue fever (DF). Thirteen patients were managed on the lines of DHF. Out of the total 63 patients, only six were locals. The common clinical presentations in these patients included high fever, retro-orbital pain, severe headache, rash, dark-colored urine, bleeding problems and hepatomegaly. Higher levels of aspartate aminotransferase (AST) were noted in comparison to alanine transferase (ALT). Despite the complicated clinical course in some patients, all patients were managed successfully and discharged, except one. Conclusion The frequency of acute hepatitis in dengue patients is high, especially in young men. Early diagnosis and prompt treatment are necessary for better prognosis. Although no specific treatment guidelines are available, supportive treatment in a timely fashion can prevent complications. Transfusion with packed cell volume (PCV) and N-acetyl cysteine (NAC) has produced promising results.

Ischemic Stroke Presenting as the First Symptom in a Setting of Paroxysmal Nocturnal Hemoglobinuria.

Paroxysmal nocturnal hemoglobinuria is a hematological disorder characterized by hemolytic anemia, cytopenia, and thrombotic events. Venous thrombotic events are more commonly reported. An arterial thrombosis is a rare event in paroxysmal nocturnal hemoglobinuria. We present a case of a 32-year-old female who had symptoms of stroke and on workup, she was diagnosed as a case of paroxysmal nocturnal hemoglobinuria.

Knowledge and Attitude About Sexually Transmitted Infections Amongst Truck Drivers in Southern Punjab, Pakistan.

INTRODUCTION: There is very limited knowledge about sexually transmitted infections (STIs) transmission and prevention present amongst high-risk groups such as truck drivers in Pakistan because of lack of awareness and understanding about barrier techniques. OBJECTIVE: The aim of this study was to collect and access the data gathered from truck drivers about symptoms of STIs, their attitude towards hazards of multiple sexual partners, homosexuality, transmission and consequences of STIs, and their perception about preventing it using condoms and other barrier methods. METHODS: This study was conducted at small roadside tea stalls and local rest areas on Karachi road, Lodhran near the city of Bahawalpur in Southern Punjab, Pakistan. A structured questionnaire was designed, and 50 willing truck drivers of the city of Bahawalpur were included and interviewed. It was a cross-sectional study. Data was collected on knowledge about the STIs and use of barrier methods like condoms. Quantitative data was assessed and analyzed using SPSS version 23.0 (IBM, NY, USA). RESULTS: Fifty truck drivers of Bahawalpur were interviewed via standardized questionnaire in this study. All of them provided answers about their knowledge of STIs. Twenty drivers (40%) reported burning micturition, and only two (four percent) knew the real cause of it. Thirty-two (64%) of them were well aware of the use of condoms. Thirty-eight (76%) truck drivers had the knowledge about the adverse effects of multiple sex partners. CONCLUSION: The truck drivers of Bahawalpur city are quite vulnerable to STIs and this demonstrates the importance of prevention programs that can target this particular group. A significant number of the respondents had serious gaps in their knowledge about STIs like acquired immunodeficiency syndrome (AIDS), especially its modes of transmission, signs, and symptoms. The knowledge of other routes of human immunodeficiency virus (HIV) transmission like needle sharing and blood transfusion, and precautionary steps should be given due respect in HIV/AIDS awareness programs.

Ceftazidime-Resistant Burkholderia Cepacia: An Unusual Case in a Pregnant Patient.

Intensive care unit (ICU) sepsis in patients is a common clinical practice primarily in the tertiary care settings. Multidrug resistance to pathogens causing ICU sepsis is widespread, and it poses a severe threat to physicians in terms of managing their patients. At times, physicians get exposed to a pathogen they have never encountered before. Burkholderia cepacia infection in immunocompetent patients is rare. This infection is common in patients with immunocompromised immunity and cystic fibrosis. We report a case of a 34-year-old female who was diagnosed with ceftazidime-resistant Burkholderia cepacia in an ICU setting. This is the first case of drug-resistant Burkholderia cepacia reported from Pakistan.

Not a Common Rectosigmoid Perforation.

Gastrointestinal perforation is a common complication arising due to homicidal injuries, trauma or intake of medications like aspirin. Intestinal perforation caused by chronic intake of mud, clay or soil is a rare phenomenon and very few cases have been reported in the literature. We hereby present the first case of rectosigmoid perforation from Pakistan which was caused by chronic mud intake in a female patient. Diagnosis of this condition in its early stage is important because it can be fatal if not addressed urgently.

Frequency of Acute Hepatitis Following Acute Paraphenylene Diamine Intoxication.

INTRODUCTION: Paraphenylene diamine (PPD) ingestion is manifesting as one of the more common ways of committing suicide in Southern Punjab, Pakistan, especially Bahawalpur. PPD is an ingredient of a compound commonly known "Kala Pathar" which means "Black Stone" in Urdu. It is readily available in the market at low cost and is used to dye hair and fur. Its intoxication inhibits cellular oxidation and affects the muscles causing rhabdomyolysis. This leads to myoglobinuria followed by renal failure and edema of face and throat resulting in respiratory difficulty. Very little is known about the impact of PPD intoxication on liver tissue. OBJECTIVE: The purpose of the study was to find out the frequency of acute hepatitis following PPD intoxication. METHODS: We reviewed the medical records of 109 patients with PPD intoxication admitted to Medical Unit-2, Bahawalpur Victoria Hospital from January 1, 2015, to June 30, 2015, in a descriptive, cross-sectional study. We noted the frequency of acute hepatitis and other complications, and we recorded the demographic features, clinical features, and outcomes of these patients. RESULTS: Our study included 32 men (29%) and 77 women (71%). The mean age was 22 ± 3.4 years, and most patients were young women aged 15 to 24 years. Suicidal ingestion was the leading cause of admission for 101 patients (93%). The most common clinical presentation was cervicofacial edema (95%), throat pain (88%), dysphonia (95%), cola-colored urine (100%), and oliguria (95%). Rhabdomyolysis (86%), acute hepatitis (51%), and acute renal failure (63%) were the most common clinical conditions following poisoning. Overall mortality was noted in 39 patients (36%) while all other patients achieved complete clinical recovery (64%). In patients with mortality, 20 of 39 (51%) developed acute hepatitis. Most patients (95%) in our study underwent tracheostomy. CONCLUSION: The frequency of acute hepatitis in PPD intoxication is high in this population, especially in young women. Measures need to be instituted regarding the management of acute hepatitis in PPD intoxication to improve patient outcomes. Workups in patients with PPD poisoning should include regular monitoring of aspartate aminotransferase and alanine aminotransferase to observe any damages to the liver so that acute hepatitis can be managed in a timely fashion.