Detalhe da pesquisa
1.
Distinct Mechanisms of Cytotoxicity in Novel Nitrogenous Heterocycles: Future Directions for a New Anti-Cancer Agent.
Molecules
; 27(8)2022 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458609
2.
Molecular Crystal Microcapsules: Formation of Sealed Hollow Chambers via Surfactant-Mediated Growth.
Angew Chem Int Ed Engl
; 59(51): 23035-23039, 2020 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32846044
3.
Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.
Bioorg Med Chem Lett
; 28(20): 3372-3375, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30201291
4.
Reversible, orally available ADP receptor (P2Y12) antagonists Part I: Hit to lead process.
Bioorg Med Chem Lett
; 28(9): 1459-1463, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29628327
5.
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.
J Pharmacol Exp Ther
; 363(3): 377-393, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28954811
6.
Synthesis, Characterization, In Silico DFT, Molecular Docking, and Dynamics Simulation Studies of Phenylhydrazono Phenoxyquinolones for Their Hypoglycemic Efficacy.
ACS Omega
; 9(14): 16384-16399, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38617610
7.
Novel 2,4-Dichloro-5-sulfamoylbenzoic Acid Oxime Esters: First Studies as Potential Human Carbonic Anhydrase Inhibitors.
ACS Med Chem Lett
; 15(6): 972-978, 2024 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38894925
8.
Synthesis of indole derivatives as Alzheimer inhibitors and their molecular docking study.
J Biomol Struct Dyn
; 41(19): 9865-9878, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36404604
9.
Synthesis of new urease enzyme inhibitors as antiulcer drug and computational study.
J Biomol Struct Dyn
; 40(18): 8232-8247, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33860726
10.
Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): in vitro effects on platelets.
Thromb Res
; 122(4): 523-32, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18495218
11.
Therapeutics discovery: From bench to first in-human trials.
Biomed Rep
; 8(3): 275-282, 2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-29564125
12.
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.
ACS Med Chem Lett
; 9(5): 472-477, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29795762
13.
A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - part I: pharmacological characterization.
Thromb Haemost
; 97(1): 45-53, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17200770
14.
A novel inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) - part II: enhancement of both exogenous and endogenous fibrinolysis in animal models of thrombosis.
Thromb Haemost
; 97(1): 54-61, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17200771
15.
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.
Thromb Haemost
; 97(5): 847-55, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17479197
16.
Why do SARS-COV vaccines not exist? The pharma scientific intelligence and business model must be revisited!
Expert Opin Drug Discov
; 15(11): 1233-1235, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32543297
17.
Structures of potent selective peptide mimetics bound to carboxypeptidase B.
Acta Crystallogr D Biol Crystallogr
; 64(Pt 2): 149-57, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18219114
18.
3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa).
Bioorg Med Chem Lett
; 17(5): 1349-54, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17189688
19.
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.
Bioorg Med Chem Lett
; 17(14): 3819-25, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17544272
20.
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.
Bioorg Med Chem Lett
; 17(14): 3814-8, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17531483