1.
Chemistry
; 27(17): 5555-5563, 2021 Mar 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33482050
RESUMO
The total synthesis of dehydroantofine was achieved by employing a novel, regioselective, azahetero Diels-Alder reaction of easily accessible 3,5-dichloro-2H-1,4-oxazin-2-one with 14 a as a key step. Furthermore, it is demonstrated that dehydroantofine is a promising candidate as a new antimalarial agent in a biological assay with chloroquine-resistant Plasmodium falciparum.