Detalhe da pesquisa
1.
EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22.
PLoS Pathog
; 18(1): e1010200, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35025968
2.
Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestosponginâ B, and Effect on Mitochondrial Function and Cancer Cell Survival.
Angew Chem Int Ed Engl
; 60(20): 11278-11282, 2021 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33751770
3.
Lithium Enolates in the Enantioselective Construction of Tetrasubstituted Carbon Centers with Chiral Lithium Amides as Noncovalent Stereodirecting Auxiliaries.
J Am Chem Soc
; 139(1): 527-533, 2017 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27997174
4.
Direct enantioselective conjugate addition of carboxylic acids with chiral lithium amides as traceless auxiliaries.
J Am Chem Soc
; 137(2): 656-9, 2015 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25562717
5.
10-Step Asymmetric Total Synthesis and Stereochemical Elucidation of (+)-Dragmacidinâ D.
Angew Chem Int Ed Engl
; 54(34): 9971-5, 2015 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26130270
6.
Imidazolone as an Amide Bioisostere in the Development of ß-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors.
J Med Chem
; 66(23): 16120-16140, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37988652
7.
Stability of cyclic imine toxins: interconversion of pinnatoxin amino ketone and pinnatoxin A in aqueous media.
J Org Chem
; 77(22): 10435-40, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23116445
8.
Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy.
J Med Chem
; 65(19): 12895-12924, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36127295
9.
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4.
J Immunother Cancer
; 8(2)2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33243932
10.
Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors.
J Med Chem
; 63(15): 8584-8607, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667798
11.
Total Synthesis of Covalent Cysteine Protease Inhibitor N-Desmethyl Thalassospiramide C and Crystallographic Evidence for Its Mode of Action.
Org Lett
; 21(2): 508-512, 2019 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30628449
12.
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment.
J Med Chem
; 62(13): 6190-6213, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31259550
13.
Enantioselective synthesis of tatanans A-C and reinvestigation of their glucokinase-activating properties.
Nat Chem
; 5(5): 410-6, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23609092