Detalhe da pesquisa
1.
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury.
Angew Chem Int Ed Engl
; 63(14): e202316496, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38348945
2.
Synthesis of Isoquinolones by Sequential Suzuki Coupling of 2-Halobenzonitriles with Vinyl Boronate Followed by Cyclization.
J Org Chem
; 86(12): 8479-8488, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34047555
3.
Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties.
Bioorg Med Chem Lett
; 30(3): 126877, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879210
4.
Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation.
Biochemistry
; 57(26): 3564-3575, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29851337
5.
Expeditious Synthesis of Isoquinolones and Isocoumarins with a Vinyl Borane as an Acetylene Equivalent.
European J Org Chem
; 2016(24): 4171-4175, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28781577
6.
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.
Angew Chem Int Ed Engl
; 55(2): 807-10, 2016 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26593377
7.
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors.
Bioorg Med Chem Lett
; 23(9): 2522-6, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23541670
8.
Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome.
Bioorg Med Chem Lett
; 23(9): 2793-800, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23540648
9.
Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs).
ACS Chem Biol
; 16(12): 2808-2815, 2021 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34780684
10.
Mutant-selective degradation by BRAF-targeting PROTACs.
Nat Commun
; 12(1): 920, 2021 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33568647
11.
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras.
Cell Chem Biol
; 28(5): 648-661.e5, 2021 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33836141
12.
Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase.
Nat Commun
; 10(1): 131, 2019 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30631068
13.
Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.
Bioorg Med Chem Lett
; 18(23): 6062-6, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18954985
14.
Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure-Degradation Relationships.
ChemMedChem
; 13(15): 1508-1512, 2018 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29870139
15.
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.
Cell Chem Biol
; 25(1): 78-87.e5, 2018 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29129718
16.
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study.
Cell Chem Biol
; 25(1): 67-77.e3, 2018 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29129716
17.
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.
J Med Chem
; 56(1): 345-56, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23214979