Pesquisa | Portal de Pesquisa da BVS

1.

Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.

Snuderl, Matija; Batista, Ana; Kirkpatrick, Nathaniel D; Ruiz de Almodovar, Carmen; Riedemann, Lars; Walsh, Elisa C; Anolik, Rachel; Huang, Yuhui; Martin, John D; Kamoun, Walid; Knevels, Ellen; Schmidt, Thomas; Farrar, Christian T; Vakoc, Benjamin J; Mohan, Nishant; Chung, Euiheon; Roberge, Sylvie; Peterson, Teresa; Bais, Carlos; Zhelyazkova, Boryana H; Yip, Stephen; Hasselblatt, Martin; Rossig, Claudia; Niemeyer, Elisabeth; Ferrara, Napoleone; Klagsbrun, Michael; Duda, Dan G; Fukumura, Dai; Xu, Lei; Carmeliet, Peter; Jain, Rakesh K.

Cell ; 152(5): 1065-76, 2013 Feb 28.

Artigo em Inglês | MEDLINE | ID: mdl-23452854

2.

Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits.

Datta, Meenal; Via, Laura E; Dartois, Véronique; Weiner, Danielle M; Zimmerman, Matthew; Kaya, Firat; Walker, April M; Fleegle, Joel D; Raplee, Isaac D; McNinch, Colton; Zarodniuk, Maksym; Kamoun, Walid S; Yue, Changli; Kumar, Ashwin S; Subudhi, Sonu; Xu, Lei; Barry, Clifton E; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 121(14): e2321336121, 2024 Apr 02.

Artigo em Inglês | MEDLINE | ID: mdl-38530888

3.

CD4⁺ T Cell Activation and Vascular Normalization: Two Sides of the Same Coin?

De Palma, Michele; Jain, Rakesh K.

Immunity ; 46(5): 773-775, 2017 05 16.

Artigo em Inglês | MEDLINE | ID: mdl-28514684

4.

A metastasis map of human cancer cell lines.

Jin, Xin; Demere, Zelalem; Nair, Karthik; Ali, Ahmed; Ferraro, Gino B; Natoli, Ted; Deik, Amy; Petronio, Lia; Tang, Andrew A; Zhu, Cong; Wang, Li; Rosenberg, Danny; Mangena, Vamsi; Roth, Jennifer; Chung, Kwanghun; Jain, Rakesh K; Clish, Clary B; Vander Heiden, Matthew G; Golub, Todd R.

Nature ; 588(7837): 331-336, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33299191

5.

Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2.

Voutouri, Chrysovalantis; Hardin, C Corey; Naranbhai, Vivek; Nikmaneshi, Mohammad R; Khandekar, Melin J; Gainor, Justin F; Stylianopoulos, Triantafyllos; Munn, Lance L; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 120(3): e2211132120, 2023 01 17.

Artigo em Inglês | MEDLINE | ID: mdl-36623200

6.

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models.

Datta, Meenal; Chatterjee, Sampurna; Perez, Elizabeth M; Gritsch, Simon; Roberge, Sylvie; Duquette, Mark; Chen, Ivy X; Naxerova, Kamila; Kumar, Ashwin S; Ghosh, Mitrajit; Emblem, Kyrre E; Ng, Mei R; Ho, William W; Kumar, Pragya; Krishnan, Shanmugarajan; Dong, Xinyue; Speranza, Maria C; Neagu, Martha R; Iorgulescu, J Bryan; Huang, Raymond Y; Youssef, Gilbert; Reardon, David A; Sharpe, Arlene H; Freeman, Gordon J; Suvà, Mario L; Xu, Lei; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 120(6): e2219199120, 2023 02 07.

Artigo em Inglês | MEDLINE | ID: mdl-36724255

7.

Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas.

Datta, Meenal; Kennedy, McCarthy; Siri, Saeed; Via, Laura E; Baish, James W; Xu, Lei; Dartois, Véronique; Barry, Clifton E; Jain, Rakesh K.

PLoS Comput Biol ; 20(2): e1011847, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38335224

8.

Retraction Note: A homing system targets therapeutic T cells to brain cancer.

Samaha, Heba; Pignata, Antonella; Fousek, Kristen; Ren, Jun; Lam, Fong W; Stossi, Fabio; Dubrulle, Julien; Salsman, Vita S; Krishnan, Shanmugarajan; Hong, Sung-Ha; Baker, Matthew L; Shree, Ankita; Gad, Ahmed Z; Shum, Thomas; Fukumura, Dai; Byrd, Tiara T; Mukherjee, Malini; Marrelli, Sean P; Orange, Jordan S; Joseph, Sujith K; Sorensen, Poul H; Taylor, Michael D; Hegde, Meenakshi; Mamonkin, Maksim; Jain, Rakesh K; El-Naggar, Shahenda; Ahmed, Nabil.

Nature ; 567(7746): 132, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30787441

9.

Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization.

Nikmaneshi, Mohammad R; Jain, Rakesh K; Munn, Lance L.

PLoS Comput Biol ; 19(6): e1011131, 2023 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-37289729

10.

Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes.

Harkos, Constantinos; Stylianopoulos, Triantafyllos; Jain, Rakesh K.

PLoS Comput Biol ; 19(12): e1011740, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-38113269

11.

A homing system targets therapeutic T cells to brain cancer.

Samaha, Heba; Pignata, Antonella; Fousek, Kristen; Ren, Jun; Lam, Fong W; Stossi, Fabio; Dubrulle, Julien; Salsman, Vita S; Krishnan, Shanmugarajan; Hong, Sung-Ha; Baker, Matthew L; Shree, Ankita; Gad, Ahmed Z; Shum, Thomas; Fukumura, Dai; Byrd, Tiara T; Mukherjee, Malini; Marrelli, Sean P; Orange, Jordan S; Joseph, Sujith K; Sorensen, Poul H; Taylor, Michael D; Hegde, Meenakshi; Mamonkin, Maksim; Jain, Rakesh K; El-Naggar, Shahenda; Ahmed, Nabil.

Nature ; 561(7723): 331-337, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30185905

12.

In silico dynamics of COVID-19 phenotypes for optimizing clinical management.

Voutouri, Chrysovalantis; Nikmaneshi, Mohammad Reza; Hardin, C Corey; Patel, Ankit B; Verma, Ashish; Khandekar, Melin J; Dutta, Sayon; Stylianopoulos, Triantafyllos; Munn, Lance L; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 118(3)2021 01 19.

Artigo em Inglês | MEDLINE | ID: mdl-33402434

13.

Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.

Ho, William W; Gomes-Santos, Igor L; Aoki, Shuichi; Datta, Meenal; Kawaguchi, Kosuke; Talele, Nilesh P; Roberge, Sylvie; Ren, Jun; Liu, Hao; Chen, Ivy X; Andersson, Patrik; Chatterjee, Sampurna; Kumar, Ashwin S; Amoozgar, Zohreh; Zhang, Qixian; Huang, Peigen; Ng, Mei Rosa; Chauhan, Vikash P; Xu, Lei; Duda, Dan G; Clark, Jeffrey W; Pittet, Mikael J; Fukumura, Dai; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 118(45)2021 11 09.

Artigo em Inglês | MEDLINE | ID: mdl-34725151

14.

Combining microenvironment normalization strategies to improve cancer immunotherapy.

Mpekris, Fotios; Voutouri, Chrysovalantis; Baish, James W; Duda, Dan G; Munn, Lance L; Stylianopoulos, Triantafyllos; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 117(7): 3728-3737, 2020 02 18.

Artigo em Inglês | MEDLINE | ID: mdl-32015113

15.

A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade.

Chen, Ivy X; Newcomer, Kathleen; Pauken, Kristen E; Juneja, Vikram R; Naxerova, Kamila; Wu, Michelle W; Pinter, Matthias; Sen, Debattama R; Singer, Meromit; Sharpe, Arlene H; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 117(38): 23684-23694, 2020 09 22.

Artigo em Inglês | MEDLINE | ID: mdl-32907939

16.

CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.

Flores-Toro, Joseph A; Luo, Defang; Gopinath, Adithya; Sarkisian, Matthew R; Campbell, James J; Charo, Israel F; Singh, Rajinder; Schall, Thomas J; Datta, Meenal; Jain, Rakesh K; Mitchell, Duane A; Harrison, Jeffrey K.

Proc Natl Acad Sci U S A ; 117(2): 1129-1138, 2020 01 14.

Artigo em Inglês | MEDLINE | ID: mdl-31879345

17.

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges.

Martin, John D; Seano, Giorgio; Jain, Rakesh K.

Annu Rev Physiol ; 81: 505-534, 2019 02 10.

Artigo em Inglês | MEDLINE | ID: mdl-30742782

18.

Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma.

Aoki, Shuichi; Inoue, Koetsu; Klein, Sebastian; Halvorsen, Stefan; Chen, Jiang; Matsui, Aya; Nikmaneshi, Mohammad R; Kitahara, Shuji; Hato, Tai; Chen, Xianfeng; Kawakubo, Kazumichi; Nia, Hadi T; Chen, Ivy; Schanne, Daniel H; Mamessier, Emilie; Shigeta, Kohei; Kikuchi, Hiroto; Ramjiawan, Rakesh R; Schmidt, Tyge Ce; Iwasaki, Masaaki; Yau, Thomas; Hong, Theodore S; Quaas, Alexander; Plum, Patrick S; Dima, Simona; Popescu, Irinel; Bardeesy, Nabeel; Munn, Lance L; Borad, Mitesh J; Sassi, Slim; Jain, Rakesh K; Zhu, Andrew X; Duda, Dan G.

Gut ; 71(1): 185-193, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-33431577

19.

Implications of a granulocyte-high glioblastoma microenvironment in immune suppression and therapy resistance.

Krishnan, Shanmugarajan; Amoozgar, Zohreh; Fukumura, Dai; Jain, Rakesh K.

J Pathol ; 254(2): 105-108, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-33534142

20.

SnapShot: Tumor angiogenesis.

Jain, Rakesh K; Carmeliet, Peter.

Cell ; 149(6): 1408-1408.e1, 2012 Jun 08.

Artigo em Inglês | MEDLINE | ID: mdl-22682256

Portal de Pesquisa da BVS

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: