Detalhe da pesquisa
1.
Mutational analysis confirms the presence of distal inhibitor-selectivity determining residues in B. stearothermophilus dihydrofolate reductase.
Arch Biochem Biophys
; 692: 108545, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32810476
2.
The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 9): 1717-25, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23999295
3.
Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate.
PLoS Negl Trop Dis
; 17(4): e0011303, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37104530
4.
Investigating the Roles of Active Site Residues in Mycobacterium tuberculosis Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents.
ACS Bio Med Chem Au
; 3(5): 438-447, 2023 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37876495
5.
Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti.
PLoS One
; 13(5): e0197173, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29787565
6.
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
J Med Chem
; 50(16): 3777-85, 2007 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17636946
7.
Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors.
J Med Chem
; 49(5): 1597-612, 2006 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16509577
8.
Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus.
Protein Sci
; 14(8): 2087-94, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15987898
9.
4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.
J Med Chem
; 48(18): 5644-7, 2005 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16134930
10.
First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling.
J Med Chem
; 46(1): 5-8, 2003 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-12502353
11.
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.
J Med Chem
; 46(9): 1627-35, 2003 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12699381
12.
Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).
J Med Chem
; 45(15): 3246-56, 2002 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12109908
13.
Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.
J Med Chem
; 56(20): 7788-803, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24093940
14.
Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain.
J Med Chem
; 56(20): 7772-87, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24083782
15.
Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor.
ACS Med Chem Lett
; 3(9): 764-8, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900545
16.
Structure of apo acyl carrier protein and a proposal to engineer protein crystallization through metal ions.
Acta Crystallogr D Biol Crystallogr
; 60(Pt 9): 1545-54, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15333924
17.
Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase.
Acta Crystallogr D Biol Crystallogr
; 58(Pt 7): 1182-92, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12077439
18.
Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases.
Antimicrob Agents Chemother
; 46(6): 1880-6, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12019104
19.
Discovery of a novel and potent class of FabI-directed antibacterial agents.
Antimicrob Agents Chemother
; 46(10): 3118-24, 2002 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12234833