Detalhe da pesquisa
1.
Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo.
Mol Ther
; 30(9): 2909-2922, 2022 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35581938
2.
Long-term stable reduction of low-density lipoprotein in nonhuman primates following in vivo genome editing of PCSK9.
Mol Ther
; 29(6): 2019-2029, 2021 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33609733
3.
Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells.
Mol Ther
; 25(4): 949-961, 2017 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28237835
4.
Male-sterile maize plants produced by targeted mutagenesis of the cytochrome P450-like gene (MS26) using a re-designed I-CreI homing endonuclease.
Plant J
; 76(5): 888-99, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24112765
5.
Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases.
FASEB J
; 27(2): 703-11, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23150522
6.
Targeted molecular trait stacking in cotton through targeted double-strand break induction.
Plant Biotechnol J
; 11(8): 933-41, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23777410
7.
Cytoplasmic male sterility and abortive seed traits generated through mitochondrial genome editing coupled with allotopic expression of atp1 in tobacco.
Front Plant Sci
; 14: 1253640, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37780496
8.
Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease.
Nat Metab
; 5(12): 2169-2183, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38036771
9.
Targeted DNA excision in Arabidopsis by a re-engineered homing endonuclease.
BMC Biotechnol
; 12: 86, 2012 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23148662
10.
Treating Transthyretin Amyloidosis via Adeno-Associated Virus Vector Delivery of Meganucleases.
Hum Gene Ther
; 33(21-22): 1174-1186, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36375122
11.
Heritable targeted mutagenesis in maize using a designed endonuclease.
Plant J
; 61(1): 176-87, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19811621
12.
Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo.
Nat Commun
; 12(1): 3210, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34050192
13.
Probing the DNA-binding affinity and specificity of designed zinc finger proteins.
Biophys J
; 98(5): 852-60, 2010 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20197039
14.
Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol.
Nat Biotechnol
; 36(8): 717-725, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29985478
15.
Binding assays get into the groove.
Nat Biotechnol
; 20(2): 126-7, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11821854
16.
Transient Expression of Virally Delivered Meganuclease In Planta Generates Inherited Genomic Deletions.
Mol Plant
; 8(8): 1292-4, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25863166
17.
Expanding the DNA-recognition repertoire for zinc finger proteins beyond 20 amino acids.
J Am Chem Soc
; 125(17): 4960-1, 2003 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12708829
18.
Reduction in DNA-binding affinity of Cys2His2 zinc finger proteins by linker phosphorylation.
Proc Natl Acad Sci U S A
; 101(20): 7589-93, 2004 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15128941
19.
The design of functional DNA-binding proteins based on zinc finger domains.
Chem Rev
; 104(2): 789-99, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14871141