Improved rehabilitation efficiency after cranioplasty in patients with sunken skin flap syndrome: a case series.

PURPOSE: Sunken Skin Flap Syndrome (SSFS) is an uncommon, delayed complication after craniectomy characterized by a functional plateau or decline with variable neurologic symptoms, improving after cranioplasty. SSFS negatively impacts the rehabilitation course, with subjective reports of functional improvement after cranioplasty. However, no studies have assessed the impact of cranioplasty on functional recovery rate. This case series aims to analyze SSFS manifestations and management while awaiting cranioplasty. Also, to assess the role of cranioplasty on rehabilitation outcomes and recovery rate in SSFS patients. METHODS: Four patients were identified with SSFS in inpatient rehabilitation. Each patient had unique clinical manifestations, with multiple strategies used for symptomatic control. Patients spent an average of 23 days in rehabilitation with SSFS symptoms before cranioplasty. After cranioplasty, all patients had SSFS symptom resolution. Comparing change in functional independence measure (FIM) scores and FIM efficiency pre-and post-cranioplasty rehabilitation course, a mean improvement of 23 and 0.72 occurred after cranioplasty, respectively. CONCLUSION: A diagnosis of SSFS should be considered in craniectomy patients exhibiting functional decline or plateau with associated neurological symptoms. This study suggests that FIM and FIM efficiency increases in SSFS patients after cranioplasty, supporting prompt cranioplasty to improve functional outcomes and minimize rehabilitation delays.

The therapeutic value of cranioplasty in individuals with brain injury.

PRIMARY OBJECTIVE: To examine the effect of cranioplasty on recovery. RESEARCH DESIGN: Retrospective cohort study. METHOD AND PROCEDURES: Retrospective chart review conducted in 2011 and 2012 on adult inpatients with craniectomy who completed a continuous episode of inpatient rehabilitation before and after receiving their cranioplasty. Patients were matched 1:1 or age, gender, functional level at admission, injury severity and length of stay with inpatients who completed rehabilitation before cranioplasty. Main outcome measures include FIMTM (Functional Independence Measure) and FIMTM efficiency [(FIMTM discharge - FIMTMadmission)/number of days in rehabilitation]. To examine within and between group differences, analyses included paired and independent t-tests, Pearson correlations and chi-square analyses. RESULTS: Twenty-six individuals (13 from the cranioplasty group and 13 from the comparison group) were analysed. FIMTM efficiency increased following cranioplasty [0.29 to 0.61; t(12) = -2.77, p = 0.017]. The mean FIMTM efficiency for the cranioplasty group was below that of the comparison group prior to cranioplasty [0.28 ± 0.37 and 0.39 ± 0.32, p = .41], but increased following cranioplasty [0.61 ± 0.71 and 0.39 ± 0.32, p = .32]. An improvement in FIMTM efficiency following cranioplasty was more commonly seen among individuals with less severe brain injuries (75%, χ2 = 3.8, df = 1, p = 0.053). CONCLUSION: Rate of recovery increased following cranioplasty and exceeded that of the comparison group suggesting that cranioplasty may contribute to improvement.

Pilot Study on the Effect of Ramelteon on Sleep Disturbance After Traumatic Brain Injury: Preliminary Evidence From a Clinical Trial.

OBJECTIVE: To investigate the effect of ramelteon on sleep and daytime functioning among individuals with traumatic brain injury (TBI). DESIGN: A double-blind, placebo-controlled study with a crossover design. SETTING: A research facility attached to an acute rehabilitation hospital. PARTICIPANTS: Individuals with TBI (N=13) complaining of sleep difficulties with a Pittsburgh Sleep Quality Index score >5. INTERVENTIONS: A nightly dosage of ramelteon (8 mg) was given over a period of 3 weeks. MAIN OUTCOME MEASURES: An actigraph and a daily sleep log were used to measure sleep/wake patterns. Daytime functioning was measured after 3 weeks of treatment using a computer-administrated neuropsychological test battery in conjunction with subjective questionnaires measuring mood, daytime sleepiness, and fatigue. RESULTS: A significant increase in objectively measured total sleep time and a small increase in sleep latency were observed after 3 weeks of treatment compared with placebo. Treatment also showed a significant increase in standardized neuropsychological test scores, with a particular improvement on an index of executive functioning. CONCLUSIONS: Preliminary evidence for the effectiveness of 8 mg of ramelteon taken nightly over a 3-week period was found in the treatment of sleep difficulties among individuals with TBI. Improvements in total sleep time and some aspects of cognitive functioning are discussed.

Impact of eliminating visual input on sitting posture and head position in a patient with spatial neglect following cerebral hemorrhage: a case report.

Background: Spatial neglect is a neurocognitive syndrome. Affected individuals pay little or insufficient attention to the space contralateral to the injured cerebral hemisphere, often resulting in or exacerbating disability following an acquired brain injury. Eliminating visual input may increase attention toward the contralesional side of space, and improve symptoms of spatial neglect; however this has never been examined in a clinical setting. Objective: In this case report, we observed an individual demonstrate immediate and spontaneous postural changes once visual input was eliminated. Methods: The patient, a 53-year-old female, was admitted to a rehabilitation hospital after hemorrhagic stroke affecting her right basal ganglia and surrounding regions in the frontal lobe. She exhibited left-sided spasticity, severe right gaze preference, and stark rightward postural deviation. Neck passive range of motion was normal. Visual field integrity was inconclusive due to poor communication and impaired cognitive function. Contraversive pushing was ruled out. Results:Once visual input was eliminated by applying a blindfold, the patient turned to the left spontaneously, had more buttock contact on the left, and placed more weight toward the left side in a sitting posture. However, she returned to rightward deviation three minutes after blindfold removal. In addition, the patient's rehabilitation team reported that she was able to participate in more therapy activities with binocular occlusion than with eyes open. Conclusion: Binocular occlusion appeared to demonstrate an immediate, albeit transient, improvement in postural symmetry. The results warrant further research and exploration in clinical applicability.

Adverse Event Profiles of High Dose Botulinum Toxin Injections for Spasticity.

BACKGROUND: Botulinum toxin injections are effective in relieving focal spasticity resulting from upper motor neuron injuries. Doses approved in the United States for onabotulinumtoxinA and incobotulinumtoxinA are up to 400 units, yet higher doses are often used. OBJECTIVE: To determine differences in risk of adverse events when using higher (>600 units) as compared to lower doses within clinically applicable categories; the difference in adverse events between types of botulinum toxin-A, and any association of the injection of cervical muscles with increased risk for adverse events. DESIGN AND SETTING: Retrospective analysis of injections performed over a 3-year period at a freestanding rehabilitation hospital network. PARTICIPANTS: Persons with spasticity or dystonia undergoing ona- and/or incobotulinumtoxinA injections. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Adverse events for injections were divided into the three dose ranges (≤400 units, 401-600 units, or > 600 units). RESULTS: 889 injections in 342 patients met inclusion criteria with 65% ≤400 units, 21% 401-600 units, and 14% >600 units. Adverse events were not significantly increased in doses of 401-600 units relative to ≤400 units (OR 0.97, 95% CI 0.31, 2.98). Doses of toxin over 600 units were associated with significantly increased relative risk of adverse events (OR 2.98, 95% CI 1.12, 8.13). There were no significant differences between adverse event rates for onabotulinumtoxinA or incobotulinumtoxinA (P >.99). Inclusion of cervical muscles in isolation did significantly increase the risk of adverse events (OR 4.21, 95% CI 1.15, 15.46). CONCLUSION: Risk for adverse events were not significantly increased in doses of ona- and/or incobotulinumtoxinA up to 600 units, suggesting that the current 400 units upper bound of approved dose may need to be reexamined. Doses above 600 units were found to increase the rate of adverse effects and clinical benefit versus risk should be taken into account. LEVEL OF EVIDENCE: III.

Robotic Exoskeleton Gait Training During Acute Stroke Inpatient Rehabilitation.

Stroke is the leading cause of severe disability in adults resulting in mobility, balance, and coordination deficits. Robotic exoskeletons (REs) for stroke rehabilitation can provide the user with consistent, high dose repetition of movement, as well as balance and stability. The goal of this intervention study is to evaluate the ability of a RE to provide high dose gait therapy and the resulting effect on functional recovery for individuals with acute stroke. The investigation included a total of 44 participants. Twenty-two participants received RE gait training during inpatient rehabilitation (RE+SOC Group), and a matched sample of 22 individuals admitted to the same inpatient rehabilitation facility-receiving conventional standard of care treatment (SOC group). The effect of RE training was quantified using total distance walked during inpatient rehabilitation and functional independence measure (FIM). The total distance walked during inpatient rehabilitation showed a significant difference between the SOC and RE+SOC groups. RE+SOC walked twice the distance as SOC during the same duration (time spent in inpatient rehabilitation) of training. In addition, the average change in motor FIM showed a significant difference between the SOC and RE+SOC groups, where the average difference in motor FIM was higher in RE+SOC compared to the SOC group. The results suggest that RE provided increased dosing of gait training without increasing the duration of training during acute stroke rehabilitation. The RE+SOC group increased their motor FIM score (change from admission to discharge) compared to SOC group, both groups were matched for admission motor FIM scores suggesting that increased dosing may have improved motor function.

Understanding the Level of Concussion Knowledge in High School Sports in New Jersey.

BACKGROUND: Coaches, athletic trainers (ATCs), and parents/guardians (parents) are important contributors to the proper identification and management of concussions in student-athletes. However, there are limited studies on the identification of concussion knowledge gaps that will help inform educational efforts and improve concussion outcomes in these groups. OBJECTIVE: To identify gaps and factors influencing concussion knowledge for high school athletics. DESIGN: Survey. SETTING: Public, private, and recreational leagues in New Jersey. PARTICIPANTS: 41 coaches, 34 ATCs, and 65 parents of high school student-athletes. METHODS: A 17-item online survey examining concussion knowledge was distributed to coaches, ATCs, and parents. Analyses included ANOVA for between-group comparisons of continuous variables and Pearson's correlations for categorical data. MAIN OUTCOME MEASUREMENTS: Demographics, concussion knowledge, application of knowledge, access to educational materials, and confidence in the ability to identify concussions. RESULTS: Significant between-group differences were found for overall knowledge (F[2137] = 11.0, P < .001), factual knowledge (F[2137] = 8.7, P < .001), and application of knowledge (F[2137] = 3.5, P = .03), with parents scoring lower. Coaches, ATCs, and parents had gaps in factual knowledge of baseline testing scores and identification regarding symptom severity. More coaches (73.2%) and ATCs (97.1%) felt confident in concussion knowledge compared with parents (31.3%; P < .001). All groups thought mandatory education, new law, and guidelines were positive in promoting better care of student-athletes. CONCLUSIONS: Knowledge gaps were identified in all groups. Educational programs for these groups should consider including targeted techniques, including vignettes, to illustrate application of concussion knowledge. LEVEL OF EVIDENCE: III.

Presence of a dedicated trauma center physiatrist improves functional outcomes following traumatic brain injury.

BACKGROUND: Maximizing long-term recovery following traumatic brain injury (TBI) is an important end point. We hypothesized that the addition of a dedicated physiatrist specializing in brain injury medicine to the trauma team would lead to improved functional outcomes. METHODS: Data from the Northern NJ TBI Model Systems were queried for all patients admitted to rehabilitation from four regional trauma centers, one with a full-time TBI physiatrist (PHYS) and three without (NO-PHYS). Patient demographics, mechanism of injury, Glasgow Coma Scale (GCS) score, length of posttraumatic amnesia, length of stay, and Functional Independence Measure (FIM) were abstracted. TBI severity was determined by GCS score and length of posttraumatic amnesia. FIM motor and cognitive scores at rehabilitation admission and discharge were the primary outcome measure. TBI medications (stimulants, sleep, and neurodepressants) administered in acute care were reviewed to evaluate prescription patterns. RESULTS: A total of 148 patients treated at four trauma centers and discharged to a single acute inpatient rehabilitation center between 2005 to 2013 were divided into two groups, PHYS with 44 patients and NO-PHYS with 104 patients. Compared with those in the NO-PHYS group, patients from the PHYS group had significant improvement in FIM motor and cognitive scores (p < 0.05). Prescription patterns differed. Patients from the PHYS group received significantly more neurostimulants (p < 0.001) and sleep medications (p = 0.02) compared with the NO-PHYS group. Analysis of covariance was conducted to examine FIM (motor and cognitive) changes from rehabilitation admission to discharge based on medications initiated in acute care. Those who received neither a neurostimulant nor a sleep medication had significantly lower FIM motor scores compared with those who received at least one of these medications (p = 0.047) and compared with those who received both types of medication (p = 0.17). No significant differences were found in FIM cognitive scores. CONCLUSION: The addition of a dedicated physiatrist providing early specialized care to patients who sustained a moderate or severe TBI was associated with improved functional outcomes upon discharge from rehabilitation. The presence of a dedicated trauma center physiatrist, trained in TBI rehabilitation, was also associated with a change in neuroprotective medication management in the acute care setting. LEVEL OF EVIDENCE: Therapeutic study, level IV.