Detalhe da pesquisa
1.
Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice.
PLoS Pathog
; 19(11): e1011627, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37956215
2.
Challenges in Chagas Disease Drug Development.
Molecules
; 25(12)2020 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32560454
3.
Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease.
Antimicrob Agents Chemother
; 62(10)2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30082291
4.
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy.
Cell Microbiol
; 18(10): 1429-43, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26918803
5.
Biological factors that impinge on Chagas disease drug development.
Parasitology
; 144(14): 1871-1880, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28831944
6.
Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds.
Angew Chem Int Ed Engl
; 55(31): 8994-8, 2016 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27314630
7.
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
Antimicrob Agents Chemother
; 59(8): 4653-61, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26014936
8.
Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy.
Nat Commun
; 15(1): 4400, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38782898
9.
Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease.
Pathogens
; 12(11)2023 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38003828
10.
Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitological cure.
PLoS Negl Trop Dis
; 16(10): e0010827, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36190992
11.
Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity.
Curr Pharm Des
; 27(14): 1733-1740, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33234096
12.
Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs".
Antimicrob Agents Chemother
; 59(12): 7925, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26578702
13.
Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection.
PLoS Negl Trop Dis
; 14(3): e0008007, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32196491
14.
Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection.
PLoS Negl Trop Dis
; 14(4): e0007717, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302312
15.
In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution.
mBio
; 11(4)2020 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32753495
16.
Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions.
Methods Mol Biol
; 1955: 147-163, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30868525
17.
Imaging the development of chronic Chagas disease after oral transmission.
Sci Rep
; 8(1): 11292, 2018 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30050153
18.
Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.
PLoS Negl Trop Dis
; 12(4): e0006388, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29608569
19.
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
J Med Chem
; 60(17): 7284-7299, 2017 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28844141
20.
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Sci Rep
; 6: 35351, 2016 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27748443