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1.
J Exp Anal Behav ; 121(3): 373-388, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38587283

RESUMO

Although scientific endeavors strive to be objective, they are the work of individuals whose unique perspectives and experiences influence their research and interpretations of the world and data. Much has been said and written lately about the need to embed cultural responsiveness in behavior analysis and the need to enhance diversity in the field. In fact, similar conversations are taking place in many areas of science. Despite the current buzz, many behavioral researchers may be left wondering what they can do or whether it is incumbent on them to act. For the field of behavior analysis to move toward adopting the values of diversity, equity, inclusion, and access, members of the scientific community must actively engage in behaviors that foster inclusive and safe learning environments for students, engage in collaborative work, and incorporate culturally responsive research and mentorship practices. This article will describe some current practices, showcase exemplars of culturally responsive research and mentorship, and provide resources for researchers and mentors.


Assuntos
Mentores , Humanos , Mentores/psicologia , Pesquisa Comportamental , Racismo/psicologia , Competência Cultural , Diversidade Cultural , Antirracismo
2.
J Appl Behav Anal ; 2024 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-38922863

RESUMO

We discuss the use of two empirically validated behavior-change methods-checklists and goal setting-and designed a checklist to assist behavior analysts in improving their behavioral services to be more culturally responsive and trauma informed. We also present pilot data evaluating the use of the checklist and goal setting on the inclusion of culturally responsive and trauma-informed practices in behavior support plans designed for students in a public school. The training package was effective for both participants, and the participants' weekly goals corresponded to the observed changes in their behavior plans. Moreover, both participants strongly agreed that the checklist was valuable and easy to use and reported increases in their perceived abilities to implement culturally responsive and trauma-informed practices posttraining.

3.
J Appl Behav Anal ; 57(3): 584-598, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38709201

RESUMO

We assessed whether novel praise statements could be used to (a) maintain and increase responses with existing reinforcement histories and (b) teach a previously untaught response among children diagnosed with autism spectrum disorder across two experiments. During response-stimulus pairing, two responses resulted in preferred edibles but only one also produced a praise statement. In the absence of edibles, the response continuing to produce praise tended to persist more. Next, reversing the praise contingency tended to increase the other response. However, in no case did contingent delivery of those same praise statements result in the acquisition of untaught responses. These findings suggest that conditioning praise statements could serve different functions (antecedent or consequence) depending on the reinforcement history for particular responses.


Assuntos
Transtorno do Espectro Autista , Reforço Psicológico , Humanos , Transtorno do Espectro Autista/psicologia , Masculino , Feminino , Criança , Pré-Escolar
4.
PLoS One ; 18(10): e0292372, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37792848

RESUMO

Researchers in social sciences increasingly rely on crowdsourcing marketplaces such as Amazon Mechanical Turk (MTurk) and Prolific to facilitate rapid, low-cost data collection from large samples. However, crowdsourcing suffers from high attrition, threatening the validity of crowdsourced studies. Separate studies have demonstrated that (1) higher pay rates and (2) additional instructions-i.e., informing participants about task requirements, asking for personal information, and describing the negative impact of attrition on research quality-can reduce attrition rates with MTurk participants. The present study extended research on these possible remedies for attrition to Prolific, another crowdsourcing marketplace with strict requirements for participant pay. We randomly assigned 225 participants to one of four groups. Across groups, we evaluated effects of pay rates commensurate with or double the US minimum wage, expanding the upper range of this independent variable; two groups also received additional instructions. Higher pay reduced attrition and correlated with more accurate performance on experimental tasks but we observed no effect of additional instructions. Overall, our findings suggest that effects of increased pay on attrition generalize to higher minimum pay rates and across crowdsourcing platforms. In contrast, effects of additional instructions might not generalize across task durations, task types, or crowdsourcing platforms.


Assuntos
Crowdsourcing , Humanos , Coleta de Dados , Renda , Pesquisadores , Ciências Sociais
5.
Occup Health Sci ; 7(1): 89-110, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36465153

RESUMO

The goal of this research was to assess the role of professional isolation on mental health symptoms via stress among employees working remotely due to COVID-19. Additionally, this research explored the interactive effect of management communication on the relationship between professional isolation and stress, and stress and mental health symptoms. In Study 1, behavior analysts who were working remotely as a result of the pandemic completed assessments of professional isolation, stress, and mental health symptoms at two points in time, separated by two weeks. Study 2 replicated and extended the findings from Study 1 in a sample of remote employees recruited from Amazon's Mechanical Turk using a three-wave design. Findings of both Study 1 and Study 2 suggested that stress mediated the relationship between professional isolation and mental health symptoms. Additionally, management communication buffered the association between stress and mental health symptoms in Study 2. Lastly, the indirect effect of professional isolation on mental health symptoms was stronger for those who received less communication from their management. The findings of these two studies expand our understanding of the mechanism and boundary condition through which professional isolation is related to mental health symptoms.

6.
J Appl Behav Anal ; 55(3): 650-673, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35411945

RESUMO

The new Ethics Code for Behavior Analysts requires that certificants engage in training related to culturally responsive service delivery (BACB, 2020). There is limited work in the area of culturally responsive evidence-based practice within our field. Therefore, it is incumbent on researchers and practitioners to identify best practices for working with diverse populations. Hence, the purpose of this paper is three-fold: a) to review research within and outside the field of ABA related to culturally responsive assessment and treatment and provide practice recommendations, b) to examine the extent to which current practices in behavior assessment and treatment align with aspects of culturally responsive practices, and c) to inspire research in the areas of behavior assessment and treatment to identify best practices with regard to culturally responsive behavior analytic practices. The content of this paper is grounded in the framework described by Beaulieu and Jimenez-Gomez (2022).


Assuntos
Competência Cultural , Humanos
7.
J Appl Behav Anal ; 55(2): 337-356, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35266143

RESUMO

Culture has a substantial impact on a wide range of behaviors related to behavioral research and services such as rapport building, preferences for specific targets and treatments, communication, and even the quality of health care. The need for professionals in the field of applied behavior analysis (ABA) to incorporate culturally responsive practices is underscored by the current and projected increase in diversity in the United States. Further, the update to the Ethics Code (BACB, 2020) supports addressing diversity in behavior analytic practice. Self-assessment of one's values, biases, and culture are a critical step in delivering culturally responsive services. The purpose of this paper is three-fold: a) to introduce a framework for cultural responsiveness in ABA, b) to showcase research and practice recommendations from within and outside the field of ABA in the area of self-assessment, and c) to inspire research in self-assessment to support cultural responsiveness in ABA.


Assuntos
Competência Cultural , Autoavaliação (Psicologia) , Comunicação , Humanos
8.
Behav Pharmacol ; 22(7): 711-3, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21921841

RESUMO

Marble-burying behavior in rodents has been used commonly as an animal model of compulsive and/or anxiety behavior. The purpose of this study was to further assess the adequacy of marble burying as a preclinical animal model of compulsive behaviors using pharmacological tools. In particular, we were interested in whether dopamine D2/D3 agonists (e.g. pramipexole) known to produce compulsive behaviors in humans would increase marble burying. The effects of pramipexole on marble-burying behavior and locomotor activity were compared with those of the following: diazepam, a drug known to decrease marble burying; D-amphetamine, a stimulant that increases locomotor activity; and methyl ß-carboline-3-carboxylate, a ß-carboline previously shown to produce anxiogenic effects in rodents. All drugs produced dose-dependent decreases in marble burying, which were not always related to the locomotor effects of these drugs. The inability of pramipexole and methyl ß-carboline-3-carboxylate to increase marble burying questions the validity of this assay as an adequate animal model of compulsive and/or anxiety behavior.


Assuntos
Ansiedade/induzido quimicamente , Comportamento Animal/efeitos dos fármacos , Benzotiazóis/farmacologia , Comportamento Compulsivo/induzido quimicamente , Agonistas de Dopamina/farmacologia , Transtorno Obsessivo-Compulsivo/induzido quimicamente , Animais , Ansiolíticos/farmacologia , Ansiedade/tratamento farmacológico , Ansiedade/fisiopatologia , Transtornos de Ansiedade/induzido quimicamente , Transtornos de Ansiedade/tratamento farmacológico , Transtornos de Ansiedade/fisiopatologia , Carbolinas/farmacologia , Carbolinas/toxicidade , Estimulantes do Sistema Nervoso Central/farmacologia , Comportamento Compulsivo/tratamento farmacológico , Comportamento Compulsivo/fisiopatologia , Convulsivantes/farmacologia , Convulsivantes/toxicidade , Dextroanfetamina/farmacologia , Diazepam/farmacologia , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Masculino , Camundongos , Atividade Motora , Transtorno Obsessivo-Compulsivo/tratamento farmacológico , Transtorno Obsessivo-Compulsivo/fisiopatologia , Pramipexol , Reprodutibilidade dos Testes
9.
Behav Pharmacol ; 22(1): 87-90, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21160425

RESUMO

Amphetamines are the second most highly abused illicit drugs worldwide, yet there is no pharmacological treatment for amphetamine abuse and dependence. Preclinical studies and, more recently, human studies, suggest that the opioid receptor antagonist, naltrexone, might be useful in the treatment of amphetamine abuse. Naltrexone, an opioid receptor antagonist, is currently used for the treatment of alcohol dependence. The aim of this study was to explore the ability of naltrexone to modify self-administration of amphetamine or ethanol in rhesus monkeys. Monkeys were trained to respond to intravenous injections of either D-amphetamine (0.003 mg/kg/injection) or ethanol (0.05 g/kg/injection) on a fixed ratio 30 schedule. Naltrexone (0.01-1 mg/kg) was administered intramuscularly 30 min before the start of treatment test sessions. Naltrexone dose-dependently decreased both amphetamine and ethanol self-administration. These findings support the potential use of naltrexone as therapy for amphetamine and polydrug abuse.


Assuntos
Anfetamina/administração & dosagem , Comportamento Animal/efeitos dos fármacos , Estimulantes do Sistema Nervoso Central/administração & dosagem , Etanol/administração & dosagem , Naltrexona/farmacologia , Antagonistas de Entorpecentes/farmacologia , Animais , Condicionamento Operante/efeitos dos fármacos , Relação Dose-Resposta a Droga , Feminino , Macaca mulatta , Masculino , Autoadministração
10.
Behav Anal Pract ; 14(4): 873-882, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34345376

RESUMO

With the abrupt transition to observing physical distancing as a result of COVID-19, applied behavior analysts were faced with the sudden need to modify their service delivery model, while at the same time managing personal difficulties brought about by the pandemic. The present article provides a description of the impact of COVID-19 on the behavior analyst workforce currently providing clinical services in the United States. We conducted a survey to assess work conditions, burnout, and productivity of behavior analysts at various certification levels. These data provide a snapshot of the impact of COVID-19 on the workforce. Overall, one third of the participants reported experiencing job insecurity, and almost half of participants reported decreased productivity and increased burnout, with remote workers more severely affected. Taken together, these factors could compromise the ability of behavior analysts to adequately provide services to their clients. We provide recommendations for behavioral health agencies for supporting staff during extreme situations such as a pandemic.

11.
J Appl Behav Anal ; 54(1): 197-216, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-32767406

RESUMO

Activity schedules consist of a series of visual discriminative stimuli, arranged in booklets or binders, which function as prompts for appropriate behavior. Although activity schedules are useful, their typical presentation in binders can be cumbersome and stigmatizing, placing additional barriers for independence and inclusion. The purpose of the present studies was to evaluate the usefulness of a wearable activity schedule and determine whether prompts provided by it would be sufficient to support completion of a complex chain of behaviors by young children. In Experiment 1, the Octopus watch® provided prompts to children of typical development to complete a morning routine independently. In Experiment 2, the usefulness of the watch was evaluated in children with autism spectrum disorder engaged in play activities in a clinical setting. In both experiments, children reliably displayed a greater proportion of independent engagement in target behaviors when prompts were delivered by the watch compared to control conditions.


Assuntos
Transtorno do Espectro Autista , Dispositivos Eletrônicos Vestíveis , Criança , Pré-Escolar , Humanos , Percepção Visual
12.
J Exp Anal Behav ; 113(1): 214-231, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31856325

RESUMO

In two laboratory experiments, we examined whether stimuli paired with alternative reinforcers could mitigate resurgence of a previously reinforced target response with pigeons (Experiment 1) and children diagnosed with Autism Spectrum Disorder (Experiment 2). In Phase 1, we arranged food reinforcement according to a variable-ratio schedule for engaging in a target response. In Phase 2, we arranged extinction for target responding and differentially reinforced alternative responding according to a fixed-ratio schedule, with every alternative-reinforcer delivery paired with a change in keylight color (Experiment 1) or automated verbal (praise) statement (Experiment 2). In Phase 3, we assessed resurgence during extinction of target and alternative responding in the presence versus absence of continued presentation of the paired stimulus. Despite variation across sessions, resurgence on average was lower when continuing to present the paired stimuli in all pigeons and children while maintenance of alternative responding did not differ between assessments. These findings indicate that stimuli paired with alternative reinforcement can modestly decrease resurgence, but further examination of their efficacy and a better understanding of the underlying processes are necessary before they can be recommended for clinical use in reducing resurgence of clinically relevant problem behavior.


Assuntos
Transtorno do Espectro Autista/psicologia , Condicionamento Operante , Sinais (Psicologia) , Reforço Psicológico , Animais , Transtorno do Espectro Autista/terapia , Criança , Pré-Escolar , Columbidae , Extinção Psicológica , Feminino , Humanos , Masculino , Recidiva , Esquema de Reforço
13.
J Exp Psychol Anim Behav Process ; 35(1): 74-91, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19159163

RESUMO

Three experiments assessed the relation between the differential outcomes effect and resistance to change of delayed matching-to-sample performance. Pigeons produced delayed matching-to-sample trials by responding on variable interval schedules in two components of a multiple schedule. In the same-outcome component, the probability of reinforcement was the same for both samples (.9 in Experiments 1 and 2, .5 in Experiment 3); in the different-outcomes component, the probability of reinforcement was .9 for one sample and .1 for the other. In all three experiments, the forgetting functions in the different-outcomes component were higher and shallower than in the same-outcomes component. When total reinforcement was greater in the same-outcomes component (Experiments 1 and 2), resistance to disruption by prefeeding, intercomponent food, extinction, or flashing lights typically was greater in that component. In Experiment 3, when total reinforcement was equated, resistance to disruption was similar across components. Thus, the level and slope of forgetting functions depended on differential reinforcement correlated with the samples, but the resistance to change of forgetting functions depended on total reinforcement in a component. Both aspects of the results can be explained by a model of delayed matching to sample performance.


Assuntos
Meio Ambiente , Rememoração Mental , Tempo de Reação , Reconhecimento Psicológico , Animais , Columbidae , Retenção Psicológica
14.
Behav Anal Pract ; 12(2): 375-386, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31976242

RESUMO

Children diagnosed with autism spectrum disorder (ASD) typically exhibit a range of social communication deficits. Presequenced stimulus arrangements, such as matrix training, can be used to facilitate generative responding. Accordingly, training procedures can lead to the acquisition of a greater number of targets that are not taught explicitly, with fewer learning trials. Matrix training provides a useful framework for selecting teaching targets to promote the emergence of untaught skills. Participants were 3 young boys diagnosed with ASD, who were taught noun-verb combinations of play actions as tact and listener responses. All participants learned the taught noun-verb targets and showed varying degrees of recombinative generalization to untaught targets. Across subsequent matrices, the rate of acquisition of new targets and the number acquired without direct teaching increased (i.e., recombinative generalization). This suggests matrix training stimulus arrangements can facilitate the acquisition of novel targets by teaching young children with ASD to recombine language components appropriately.

15.
J Exp Anal Behav ; 111(3): 416-435, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30706484

RESUMO

The present study examined whether resurgence of a previously reinforced target response upon removing alternative reinforcement would be greater when (1) returning to the original training context (ABA context changes) versus (2) remaining in the analogue treatment context in which the alternative response was differentially reinforced (ABB context changes). Experiment 1 arranged reinforcement of button pressing with points exchangeable for money in university students. Experiment 2 arranged reinforcement of lever pressing with food for rats. Experiment 3 arranged reinforcement of responses to a touchscreen with small bites of food with children diagnosed with ASD. Overall, resurgence of target responding tended to be greater when returning to the original training context (A) than when remaining in the analogue treatment context (B). These findings suggest context changes with differential reinforcement treatments could exacerbate the recurrence of problem behavior resulting from reductions in treatment integrity through failure to reinforce appropriate behavior.


Assuntos
Condicionamento Operante , Extinção Psicológica , Retenção Psicológica , Animais , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Ratos , Ratos Wistar , Reforço Psicológico , Recompensa , Adulto Jovem
16.
J Appl Behav Anal ; 50(3): 675-697, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28608584

RESUMO

Behavioral treatment gains established in one setting do not always maintain in other settings. The present review examines the relevance of basic and translational research to understanding failures to maintain treatment gains across settings. Specifically, studies of the renewal effect examine how transitioning away from a treatment setting could evoke a return of undesirable behavior, rather than newly trained appropriate behavior. Studies of renewal typically arrange three phases, with a response trained and reinforced under a particular set of contextual stimuli in the first phase. Next, that response is extinguished, often under a different set of contextual stimuli. Finally, that response returns despite extinction remaining in effect upon returning to the original training context or transitioning to a novel context. Thus, removing the extinction context is sufficient to produce a recurrence of the response. The findings suggest treatment effects can become specific to the context in which the treatment was delivered. This literature offers promising methods for systematically assessing the factors contributing to treatment maintenance and improving generalization of treatment gains across contexts. Therefore, the present review suggests basic and translational research on renewal provides an empirical literature to bring greater conceptual systematization to understanding generalization and maintenance of behavioral treatment.


Assuntos
Terapia Comportamental , Meio Ambiente , Generalização Psicológica , Humanos
17.
J Exp Anal Behav ; 85(2): 167-80, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16673824

RESUMO

Attempts to examine the effects of variations in relative conditioned reinforcement rate on choice have been confounded by changes in rates of primary reinforcement or changes in the value of the conditioned reinforcer. To avoid these problems, this experiment used concurrent observing responses to examine sensitivity of choice to relative conditioned reinforcement rate. In the absence of observing responses, unsignaled periods of food delivery on a variable-interval 90-s schedule alternated with extinction on a center key (i.e., a mixed schedule was in effect). Two concurrently available observing responses produced 15-s access to a stimulus differentially associated with the schedule of food delivery (S+). The relative rate of S+ deliveries arranged by independent variable-interval schedules for the two observing responses varied across conditions. The relation between the ratio of observing responses and the ratio of S+ deliveries was well described by the generalized matching law, despite the absence of changes in the rate of food delivery. In addition, the value of the S+ deliveries likely remained constant across conditions because the ratio of S+ to mixed schedule food deliveries remained constant. Assuming that S+ deliveries serve as conditioned reinforcers, these findings are consistent with the functional similarity between primary and conditioned reinforcers suggested by general choice theories based on the concatenated matching law (e.g., contextual choice and hyperbolic value-added models). These findings are inconsistent with delay reduction theory, which has no terms for the effects of rate of conditioned reinforcement in the absence of changes in rate of primary reinforcement.


Assuntos
Comportamento de Escolha , Condicionamento Psicológico , Reforço Psicológico , Animais , Comportamento Animal/fisiologia , Columbidae , Comportamento Alimentar
18.
J Exp Anal Behav ; 85(3): 329-47, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16776055

RESUMO

Previous experiments have shown that unsignaled delayed reinforcement decreases response rates and resistance to change. However, the effects of different delays to reinforcement on underlying response structure have not been investigated in conjunction with tests of resistance to change. In the present experiment, pigeons responded on a three-component multiple variable-interval schedule for food presented immediately, following brief (0.5 s), or following long (3 s) unsignaled delays of reinforcement. Baseline response rates were lowest in the component with the longest delay; they were about equal with immediate and briefly delayed reinforcers. Resistance to disruption by presession feeding, response-independent food during the intercomponent interval, and extinction was slightly but consistently lower as delays increased. Because log survivor functions of interresponse times (IRTs) deviated from simple modes of bout initiations and within-bout responding, an IRT-cutoff method was used to examine underlying response structure. These analyses suggested that baseline rates of initiating bouts of responding decreased as scheduled delays increased, and within-bout response rates tended to be lower in the component with immediate reinforcers. The number of responses per bout was not reliably affected by reinforcer delay, but tended to be highest with brief delays when total response rates were higher in that component. Consistent with previous findings, resistance to change of overall response rate was highly correlated with resistance to change of bout-initiation rates but not with within-bout responding. These results suggest that unsignaled delays to reinforcement affect resistance to change through changes in the probability of initiating a response bout rather than through changes in the underlying response structure.


Assuntos
Meio Ambiente , Tempo de Reação , Reforço Psicológico , Percepção do Tempo , Animais , Comportamento Animal , Columbidae , Comportamento Alimentar
19.
Behav Processes ; 128: 24-8, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27045696

RESUMO

Contrafreeloading involves organisms working for food when an identical source of food is freely available. The present study assessed whether training reinforcement rates influenced contrafreeloading by arranging a within-subject and within-session design using pigeons. Across different alternating discriminative stimuli, variable-interval schedules arranged leaner (30 per hour) and richer (120 per hour) rates of food reinforcement. Responding decreased but persisted in the presence of free food during the session (i.e., contrafreeloading). Further, responding tended to be similar between components initially but greater persistence emerged in the richer component with additional exposure. With pre-session feeding, responding did not change systematically across test sessions and tended to be more persistent in the richer component. Greater persistence with greater training reinforcement rates is generally consistent with an influential theory of response persistence, behavioral momentum theory. However, the different patterns of responding across test sessions between pre- and within-session feeding reveals multiple behavioral processes involved in contrafreeloading that have yet to be fully understood. Behavioral momentum theory could provide a useful theoretical framework for understanding and quantifying the behavioral processes underlying contrafreeloading.


Assuntos
Columbidae , Comportamento Alimentar , Teoria Psicológica , Reforço Psicológico , Animais , Condicionamento Operante , Esquema de Reforço
20.
J Med Chem ; 57(10): 4049-57, 2014 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-24761755

RESUMO

Emerging clinical and preclinical evidence suggests that a compound displaying high affinity for µ, κ, and δ opioid (MOP, KOP, and DOP) receptors and antagonist activity at each, coupled with moderate affinity and efficacy at nociceptin opioid peptide (NOP) receptors will have utility as a relapse prevention agent for multiple types of drug abuse. Members of the orvinol family of opioid ligands have the desired affinity profile but have typically displayed substantial efficacy at MOP and or KOP receptors. In this study it is shown that a phenyl ring analogue (1d) of buprenorphine displays the desired profile in vitro with high, nonselective affinity for the MOP, KOP, and DOP receptors coupled with moderate affinity for NOP receptors. In vivo, 1d lacked any opioid agonist activity and was an antagonist of both the MOP receptor agonist morphine and the KOP receptor agonist ethylketocyclazocine, confirming the desired opioid receptor profile in vivo.


Assuntos
Buprenorfina/análogos & derivados , Antagonistas de Entorpecentes , Antagonistas de Entorpecentes/síntese química , Animais , Descoberta de Drogas , Ligantes , Camundongos , Antagonistas de Entorpecentes/farmacologia , Receptores Opioides/metabolismo , Relação Estrutura-Atividade , Receptor de Nociceptina
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