1.
J Med Chem
; 52(9): 3098-102, 2009 May 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19348415
RESUMO
The identification and progression of a potent and selective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta) are described. Hit-generation chemistry based on IKK-beta active-site knowledge yielded a weakly potent but tractable chemotype that was rapidly progressed into a series with robust enzyme and cellular activity and significant selectivity over IKK-alpha.