1.
Org Lett
; 25(40): 7310-7315, 2023 Oct 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37791996
RESUMO
A one-pot, regioselective decarboxylative alkynylation of tetrahydro-ß-carboline-1-carboxylic acid under peroxide-free condition is reported. The reaction is highly selective for the 1-position over the 3-position of tetrahydro-ß-carboline. The reaction can afford alkynylated or enaminone products depending on the reagent. The reaction proceeds through sequential decarboxylative iminium ion formation followed by an alkynylation and oxidative rearrangement cascade.