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1.
J Pediatr ; 268: 113930, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38309525

RESUMO

OBJECTIVE: To evaluate whether racial and socioeconomic inequities in pediatric palliative care utilization extend to children with high-intensity neurologic impairment (HI-NI), which is a chronic neurological diagnosis resulting in substantial functional morbidity and mortality. STUDY DESIGN: We conducted a retrospective study of patients with HI-NI who received primary care services at a tertiary care center from 2014 through 2019. HI-NI diagnoses that warranted a palliative care referral were identified by consensus of a multidisciplinary team. The outcome was referral to palliative care. The primary exposure was race, categorized as Black or non-Black to represent the impact of anti-Black racism. Additional exposures included ethnicity (Hispanic/non-Hispanic) and insurance status (Medicaid/non-Medicaid). Descriptive statistics, bivariate analyses, and multivariable logistic regression models were performed to assess associations between exposures and palliative care referral. RESULTS: A total of 801 patients with HI-NI were included; 7.5% received a palliative referral. There were no differences in gestational age, sex, or ethnicity between patients who received a referral and those who did not. In multivariable analysis, adjusting for ethnicity, sex, gestational age, and presence of complex chronic conditions, Black children (aOR 0.47, 95% CI 0.26, 0.84) and children with Medicaid insurance (aOR 0.40, 95% CI 0.23, 0.70) each had significantly lower odds of palliative referral compared with their non-Black and non-Medicaid-insured peers, respectively. CONCLUSIONS: We identified inequities in pediatric palliative care referral among children with HI-NI by race and insurance status. Future work is needed to develop interventions, with families, aimed at promoting more equitable, antiracist systems of palliative care.


Assuntos
Disparidades em Assistência à Saúde , Doenças do Sistema Nervoso , Cuidados Paliativos , Encaminhamento e Consulta , Humanos , Cuidados Paliativos/estatística & dados numéricos , Masculino , Feminino , Estudos Retrospectivos , Encaminhamento e Consulta/estatística & dados numéricos , Criança , Disparidades em Assistência à Saúde/etnologia , Disparidades em Assistência à Saúde/estatística & dados numéricos , Pré-Escolar , Doenças do Sistema Nervoso/terapia , Doenças do Sistema Nervoso/etnologia , Lactente , Estados Unidos , Adolescente , Negro ou Afro-Americano/estatística & dados numéricos , Fatores Socioeconômicos , Medicaid/estatística & dados numéricos , Racismo
2.
Inorg Chem ; 63(19): 8516-8520, 2024 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-38667056

RESUMO

Related BAP [BAP = bis(acyl)phosphide] and Acac (Acac = ß-diketonate) molecules perform as robust supports for both lanthanide and actinide metals. Here, a molecular bimetallic Eu2+ complex was successfully targeted and isolated by employing sodium bis(mesitoyl)phosphide [Na(mesBAP)] in a salt metathesis with EuI2, producing [Eu(mesBAP)2(et2o)]2 (et2o = metal-coordinated diethyl ether). The corresponding Acac-Eu2+ complex was targeted using mesAcac- (1,3-dimesityl-1,3-propanedione), generating [Eu(mesAcac)2(et2o)]2. Both complexes were characterized by single-crystal X-ray diffraction, UV-vis, IR, and NMR spectroscopies, and variable-temperature magnetic susceptibility. [Eu(mesBAP)2(et2o)]2 was persistent under anaerobic, anhydrous conditions, whereas the analogous [Eu(mesAcac)2(et2o)]2 showed evidence of decomposition under identical conditions. Variable-temperature magnetic susceptibility and magnetization studies of [Eu(mesBAP)2(et2o)]2 and [Eu(mesAcac)2(et2o)]2 were performed, resulting in similar magnetic exchange coupling values of Jex = -0.018 and -0.023 cm-1 and axial zero-field-splitting D values of -0.38 and -0.51 cm-1, respectively.

3.
Health Commun ; 39(1): 195-204, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36593220

RESUMO

The current project sought to extend prior research examining organ donation portrayals on Grey's Anatomy by examining the first fifteen seasons. Guided by the health belief model, content analysis revealed more attention was given to benefits of donation than barriers. Contrary to previous research, more attention was given to refuting rather than promoting commonly cited myths. The results also address attention to the health threat as well as Grey's Anatomy's representation of self-efficacy in registering to be an organ donor. Finally, proportion tests revealed significant differences between the types of organs transplanted on Grey's Anatomy compared to organs transplanted in the United States. The results are discussed with an emphasis on portrayal trends throughout Season 1 through 15 as well as the theoretical and practical implications of our findings.


Assuntos
Televisão , Obtenção de Tecidos e Órgãos , Humanos , Estados Unidos , Estações do Ano , Autoeficácia
4.
J Strength Cond Res ; 38(2): 311-317, 2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-37815277

RESUMO

ABSTRACT: Magee, MK, Fields, JB, Jagim, AR, and Jones, MT. Fat-free mass index in a large sample of National Collegiate Athletic Association men and women athletes from a variety of sports. J Strength Cond Res 38(2): 311-317, 2024-Fat-free mass index (FFMI) can be used to categorize fat-free mass (FFM) relative to height. Normative values have been established in a variety of sports, as has suggested lower and upper thresholds of FFMI. However, FFMI has not been reported in a large sample of athletes, representing both sexes and multiple sport types. The purpose of this study was to evaluate differences in FFMI and establish normative values across a large sample of collegiate sports. A total of 1,961 athletes (men: n = 596, 10 sports; women: n = 1,365, 8 sports) participated. Height and mass were measured using a stadiometer and calibrated digital scale, respectively. Fat-free mass was assessed with air displacement plethysmography and used to calculate FFMI. Kruskal-Wallis test and one-way analysis of variance evaluated differences in FFMI in women's and men's sports, respectively. When collapsed across sport type and stratified by sex, men had a higher FFMI (21.5 ± 1.9 kg·m -2 vs. 17.9 ± 1.8 kg·m -2 ; p < 0.001). Differences occurred in FFMI across sport. In women, basketball athletes had the highest FFMI (18.9 kg·m -2 ) and highest 99th percentile for FFMI, whereas rowers had the lowest (16.9 kg·m -2 ). In men, throwers had the highest FFMI (25.7 kg·m -2 ) and highest 99th percentile, whereas volleyball athletes had the lowest (19.9 kg·m -2 ). Differences in FFMI may be attributable to dietary habits and physiological demands of respective sports. These results can provide information relative to differences in FFMI values across sports. In addition, sport-specific normative values can be used as benchmarks and targets for training, nutrition, and goal setting.


Assuntos
Traumatismos em Atletas , Basquetebol , Voleibol , Masculino , Humanos , Feminino , Composição Corporal/fisiologia , Atletas , Estado Nutricional , Universidades
5.
J Strength Cond Res ; 38(2): 318-324, 2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-37820260

RESUMO

ABSTRACT: Brown, FSA, Fields, JB, Jagim, AR, Baker, RE, and Jones, MT. Analysis of in-season external load and sport performance in women's collegiate basketball. J Strength Cond Res 38(2): 318-324, 2024-Quantifying and monitoring athlete workload throughout a competitive season is a means to manage player readiness. Therefore, the purpose of the current study was to quantify practice and game external loads and to assess the relationship between such loads and basketball-specific performance metrics across a women's collegiate basketball season. Thirteen National Collegiate Athletic Association Division I women basketball athletes (age 20.08 ± 1.55 years) wore Global Positioning Systems sensors equipped with triaxial accelerometers for 29 games and 66 practices during the 2019-20 season. A multivariate analysis of variance was used to assess differences in external load between high- and low-minute players and across quarters within games ( p < 0.05). Bivariate Pearson correlation coefficients were run to determine relationships between external loads and metrics of basketball performance. Findings indicated that high- and low-minute athletes experienced different loads during games and practices ( p < 0.001). External loads differed by quarter, such that player load (PL) was highest in Q4 ( p = 0.007), PL·min -1 was highest in Q1 and lowest in Q4 ( p < 0.001), and explosive ratio (i.e., ratio of PL and explosive efforts) was lowest in Q3 ( p = 0.45). Relationships existed between PL·min -1 and field goals ( r = 0.41; p = 0.02) and between the explosive ratio and free throws ( r = 0.377 p = 0.04). These results can be used to inform design of training sessions with the intent to prepare athletes for the demands of the competitive season. It is recommended that future research continue to explore the relationship of sport-specific performance metrics and athlete external load.


Assuntos
Basquetebol , Humanos , Feminino , Adolescente , Adulto Jovem , Adulto , Estações do Ano , Universidades , Atletas , Sistemas de Informação Geográfica
6.
J Nerv Ment Dis ; 211(12): 940-947, 2023 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-37428877

RESUMO

ABSTRACT: Military service and ex-service personnel commonly experience difficulties with anger. The COVID-19 pandemic had several negative consequences upon social, economic, and health factors that influence anger. This study aimed to explore 1) levels of anger in an ex-serving military cohort during the COVID-19 pandemic; 2) self-reported changes in anger compared with prepandemic levels; and 3) identify sociodemographic characteristics, military characteristics, COVID-19 experiences, and COVID-19 stressors associated with anger. UK ex-service personnel ( n = 1499) completed the Dimensions of Anger Reactions 5-item measure within an existing cohort study. Overall, 14.4% reported significant difficulties with anger, and 24.8% reported their anger worsened during the pandemic. Anger was associated with factors such as financial difficulties, extra/new caring responsibilities, and COVID-19 bereavement. Endorsing more COVID-19 stressors was associated with higher odds of anger difficulties. This study highlights the impact of the pandemic on ex-service personnel, including a strain on family/social relationships and financial hardship, which affected anger.


Assuntos
COVID-19 , Militares , Humanos , Pandemias , Estudos de Coortes , COVID-19/epidemiologia , Ira , Reino Unido/epidemiologia
7.
Eur J Appl Physiol ; 123(7): 1529-1541, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36929015

RESUMO

BACKGROUND: Stationary (SE) and dynamic (DE) rowing ergometers, that are utilized for indoor training and physical assessment of competitive rowers, may elicit different physiological and biomechanical responses. The present study used SE and DE ergometers to examine submaximal and peak physiological and biomechanical responses during an incremental rowing test. METHODS: Twelve National Collegiate Athletic Association (NCAA) Division I oarswomen performed seven-stage rowing tests with the last stage performed with maximal effort. Heart rate (HR), lactate (LA), oxygen uptake (VO2), ventilation (VE), stroke rate (SR), gross efficiency (GE), and rating of perceived exertion (RPE) were obtained; while trunk, hip, knee, shoulder, and elbow ranges of motion (ROM) were measured. RESULTS: SR was higher at maximal stage DE (29.3 vs. 34.8 strokes/min, p = 0.018, d = 1.213). No difference occurred in responses of maximal stage HR, RPE, VO2, VE, LA, or GE between the two ergometers. Submaximal LA and SR were greater on the DE for all submaximal stages. Submaximal VE was greater on the DE for all submaximal stages except Stage 3 (p = 0.160, d = 0.655). VO2 was higher on the DE Stages 2-5. GE was higher on the SE for Stages 2-5. Athletes showed increased trunk (p = 0.025, [Formula: see text] = 0.488) and knee (p = 0.004, [Formula: see text] = 0.668) ROM on SE. CONCLUSION: Rowing on the DE appears to elicit a greater stroke rate and more optimal joint angles especially at high intensities. Hence, the DE is worthy of consideration as a preferred ergometer for women rowers.


Assuntos
Esportes , Esportes Aquáticos , Humanos , Feminino , Ergometria , Exercício Físico/fisiologia , Esportes/fisiologia , Teste de Esforço , Frequência Cardíaca , Atletas , Consumo de Oxigênio/fisiologia
8.
South Med J ; 116(2): 188-194, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36724534

RESUMO

OBJECTIVES: Low-income Latinx youth are disproportionately affected by obesity, which results in an increased risk of cardiometabolic abnormalities. Biomarker tracking may be useful for the early identification of obesity comorbidities in young Latinx children. Hence, we aimed to compare cardiometabolic biomarkers between age- and sex-matched pairs of elementary school-aged Latinx children with obesity versus healthy weight. METHODS: This case-control study compared cardiometabolic biomarkers between 13 pairs of age- and sex-matched elementary school-age (median 6.5 years) Latinx children with obesity (body mass index for age ≥ 95th percentile) as compared with their healthy weight (between the 5th and 85th percentiles) counterparts. Anthropometric measures and a fasted venous blood sample were taken for the analysis of lipids, glycemic, inflammatory, endocrine, and hepatic markers. Group differences were tested by the Mann-Whitney U or χ2 test. RESULTS: Cases had higher insulin (P = 0.003), hemoglobin A1c (P = 0.002), triglycerides (P = 0.023), and C-reactive protein (P < 0.001) and lower high-density lipoprotein (P = 0.002). Hepatic markers were similar, with alanine aminotransferase elevated among both groups. CONCLUSIONS: The aforementioned biomarkers may be more sensitive to higher adiposity risk in this young Latinx population; however, elevated hepatic markers may indicate an ethnic/genetic predisposition to abnormal liver function. Research should be replicated in a larger group to confirm these findings.


Assuntos
Doenças Cardiovasculares , Obesidade Infantil , Criança , Humanos , Biomarcadores , Índice de Massa Corporal , Doenças Cardiovasculares/epidemiologia , Estudos de Casos e Controles , Hispânico ou Latino , Fatores de Risco , Obesidade Infantil/complicações , Obesidade Infantil/epidemiologia
9.
J Strength Cond Res ; 37(8): e455-e461, 2023 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-36727683

RESUMO

ABSTRACT: Fields, JB, Jones, MT, Feit, MK, and Jagim, AR. Athlete external loads across a collegiate men's lacrosse season. J Strength Cond Res 37(8): e455-e461, 2023-Tracking and quantifying athlete workload may provide insight into best practice periodization strategies and workload management. Limited information exists detailing the external demands associated with collegiate men's lacrosse. Therefore, the purpose of this study was to investigate and compare practice, game, and positional differences across a lacrosse season. Male collegiate lacrosse athletes ( n = 17; body mass: 79.9 kg ± 9.7 kg; body fat %: 14.7 ± 3.8%) wore a global positional system device during practices ( n = 66) and games ( n = 19). External load metrics were total distance (TD), sprint distance (SD), accelerations (>3 m·s -2 ), sprint efforts, player load (PL), PL/min, and top speed. Multiple analysis of variances assessed differences in external loads across session (practice versus game) and sport position (attackers, midfielders, and defenders). A 3 × 4 analysis of variance was used to determine a position-by-time (first quarter [Q1], second quarter [Q2], third quarter [Q3], and fourth quarter [Q4]) interaction ( p < 0.05). Total distance ( p < 0.001, η2 : 0.047), SD ( p < 0.001, η2 : 0.093), sprint efforts ( p < 0.001, η2 : 0.077), PL ( p < 0.001, η2 : 0.022), and top speeds ( p < 0.001, η2 : 0.086) were all higher in games compared with practices. Attackers and defenders covered more TD ( p < 0.001, η2 = 0.0257), accelerations ( p < 0.001, η2 = 0.126), PL ( p < 0.001, η2 = 0.233), and PL/min ( p < 0.001, η2 = 0.193) than midfielders. Attackers and midfielders covered more SD ( p = 0.002 η2 = 0.043), sprint efforts ( p < 0.001, η2 = 0.053), and achieved higher top speed ( p < 0.001, η2 = 0.0063) than defenders. Volume and intensity metrics declined by Q4 in attackers and defenders ( p < 0.05), whereas external load measures did not differ across quarters for midfielders. Monitoring in-game external loads can assist coaches with individualizing training programs and preparing athletes for game demands.


Assuntos
Futebol Americano , Esportes com Raquete , Humanos , Masculino , Estações do Ano , Universidades , Atletas
10.
J Strength Cond Res ; 37(8): 1623-1627, 2023 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-36752757

RESUMO

ABSTRACT: Burke, AA, Guthrie, BM, Magee, M, Miller, AD, and Jones, MT. Revisiting the assessment of strength, power, and change of direction in collegiate american football athletes. J Strength Cond Res 37(8): 1623-1627, 2023-The primary purpose was to assess the effect of strength on vertical jump (VJ) and change of direction (COD) with a secondary purpose to examine if these relationships were moderated by the sport position group through path analysis using structural equation modeling. Subjects were collegiate American football athletes grouped by skill (SK; n = 98) and nonskill (NS; n = 83) sport position groups. Maximal strength was assessed by 1 repetition maximum back squat and hang clean (HC). Vertical jump was used to evaluate power. Change of direction was assessed through the 20-yard shuttle (i.e., 5-10-5) test. Multigroup path analysis examined causal pathways among variables and moderating effects of sport position. The final model revealed that VJ fully mediated the relationship between HC and COD (HC-VJ: ß = 0.408, p < 0.001; VJ-COD: ß = -0.376, p < 0.001; and HC-COD: ß = -0.137, p = 0.17) in SK. The NS showed only direct effects of HC on COD ( ß = -0.335, p < 0.001). These findings suggest that strength does not solely explain COD ability but also can serve to enhance underpinning qualities, such as relative force production in the VJ. Relationships between strength, power, and COD are different depending on the positional group. The results provide further insight into performance outcomes in field tests. It is recommended that sport position differences be considered when assessing and analyzing physical qualities in a team setting within the sport of American football.


Assuntos
Desempenho Atlético , Futebol Americano , Humanos , Teste de Esforço , Atletas , Força Muscular
11.
J Strength Cond Res ; 37(11): 2213-2221, 2023 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-37639657

RESUMO

ABSTRACT: Fields, JB, Kuhlman, NM, Jagim, AR, Dulak-Sigler, C, and Jones, MT. Analysis of accumulated workloads and performance testing across a collegiate women's lacrosse season. J Strength Cond Res 37(11): 2213-2221, 2023-Monitoring accumulated workloads, acute:chronic workload ratios (ACWR), and training monotony (TM) are practical methods for monitoring athlete physical stress. Performance testing provides useful information about the changing nature of physical abilities. Therefore, the purpose was to examine differences in accumulated workloads based on session type, explore seasonal trends in ACWR and TM, and assess changes in performance assessments in collegiate women's lacrosse athletes. Athletes, who were identified as starters ( n = 12), wore positional monitoring technology during training sessions ( n = 61) and games ( n = 17) and completed preseason and postseason assessments of speed, agility, power (jump tests), strength, aerobic capacity, and body composition. Separate 1-way analyses of variance were used to determine differences in accumulated workloads for session type and differences in performance assessments from preseason to postseason ( p < 0.05). When compared with games, practice sessions elicited greater ( p < 0.001) accumulated total distance, player load, repeated high-intensity efforts, accelerations, change of direction, explosive efforts, high-speed efforts ( p = 0.002), and high-speed distance ( p = 0.002). Throughout the season, ACWR and TM ranged from 0.16 to 1.40 AU and 0.68-1.69 AU, respectively. The 40-yd sprint ( p < 0.001) and pro-agility ( p < 0.001) improved from preseason to postseason, whereas no changes in aerobic capacity, lower-body power, or strength were observed ( p > 0.05). The monitoring of accumulated loads, ACWR and TM, and performance tests revealed novel information about the seasonal demands of collegiate women's lacrosse. Women lacrosse players are able to improve speed and agility throughout the season, while maintaining strength, power, and endurance, with minimal reductions in fat-free mass.


Assuntos
Esportes com Raquete , Carga de Trabalho , Humanos , Feminino , Estações do Ano , Atletas
12.
J Strength Cond Res ; 37(11): 2206-2212, 2023 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-37639668

RESUMO

ABSTRACT: Askow, AT, Jennings, W, Jagim, AR, Fields, JB, Beaudoin, RG, Sanchez, GM, Weeks, JE, Oliver, JM, and Jones, MT. Athlete external load measures across a competitive season in high school basketball. J Strength Cond Res 37(11): 2206-2212, 2023-The purpose of this retrospective analysis was to quantify in-season external load and to determine if relationships existed between load metrics and basketball performance. Eleven male high school varsity basketball athletes (n = 11; mass 80.5 ± 9.6 kg, height 190.2 ± 9.4 cm, age 17.6 ± 0.7 years) were monitored across a season. PlayerLoad (PL), PL per minute (PL·min -1 ), total jumps, and explosive movements (EMs) were quantified using a commercially available local positioning unit. Basketball-specific performance metrics, including points scored, points allowed, point differentials, and shooting percentages for each quarter and game, were compiled. Data were analyzed using repeated-measure analysis of variance to evaluate differences in load by starting status, session type, game outcome, and game type. Pearson's correlation coefficients were used to assess relationships between load metrics and basketball performance. Statistical significance was set at p < 0.05. The mean values across 23 games for PL, PL·min -1 , total jumps, and EMs were 457 ± 104 AU, 10.9 ± 1.6 AU, 42.6 ± 9.6, and 46.7 ± 7.2, respectively. Relationships were observed ( p < 0.05) between PL and points scored ( r = 0.38) and free throw percentage ( r = 0.21). Further relationships were observed between PL·min -1 and free throw shooting percentage ( r = -0.27), and between points scored and total jumps ( r = 0.28), and EMs ( r = 0.26). Notable differences in game demands were observed for playing status. Meaningful differences in measures of external load were observed between each quarter of play, with the highest measures evident in quarters 1 and 3. Guards and forwards experienced minimal differences in external load during gameplay, and game outcome did not result in differences. Higher point totals corresponded with higher PL, total jumps, and EM.


Assuntos
Basquetebol , Humanos , Masculino , Adolescente , Estações do Ano , Estudos Retrospectivos , Atletas , Instituições Acadêmicas
13.
Biol Sport ; 40(4): 1141-1150, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37867741

RESUMO

The purpose was to examine relationships between external loads (ELs), perceived exertion, and soreness. Collegiate men soccer players (n = 19) were monitored for 72 sessions (training: n = 53; matches: n = 19). Likert scale assessments (0-6) of lower body soreness were collected prior to each session, and ELs were collected using positional monitoring technology. Session rate of perceived exertion (sRPE-load) was calculated by multiplying perceived exertion values (Borg CR-10 Scale) by respective session duration to determine internal load. Multiple analyses of variance were used to determine differences in ELs across seasons (pre-season, in-season, post-season) and sessions (training, match). Bivariate Pearson correlation coefficients and linear regression analyses were used to evaluate relationships among soreness, ELs, and sRPE-load. Greatest ELs were observed during pre-season and post-season phases (p < 0.001). Sessions with high perceived exertion and low soreness were associated with higher ELs (p < 0.05). Duration (t = 16.13), total distance (t = 9.17), sprint distance (t = 7.54), player load (t = 4.22), top speed (t = 4.69), and acceleration (t = 2.02) positively predicted sRPE-load (F = 412.9, p < 0.001, R2 = 0.75). Soreness was weakly and trivially correlated with ELs (p < 0.05). The very strong relationship between ELs and sRPE-load highlights the utility of sRPE-load as a practical means to estimate workload; however, more research into the relationship between soreness and workload is warranted.

14.
Nat Immunol ; 11(11): 1039-46, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20890286

RESUMO

Neutrophils are the main effector cells during inflammation, but they can also control excessive inflammatory responses by secreting anti-inflammatory cytokines. However, the mechanisms that modulate their plasticity remain unclear. We now show that systemic serum amyloid A 1 (SAA-1) controls the plasticity of neutrophil differentiation. SAA-1 not only induced anti-inflammatory interleukin 10 (IL-10)-secreting neutrophils but also promoted the interaction of invariant natural killer T cells (iNKT cells) with those neutrophils, a process that limited their suppressive activity by diminishing the production of IL-10 and enhancing the production of IL-12. Because SAA-1-producing melanomas promoted differentiation of IL-10-secreting neutrophils, harnessing iNKT cells could be useful therapeutically by decreasing the frequency of immunosuppressive neutrophils and restoring tumor-specific immune responses.


Assuntos
Diferenciação Celular/imunologia , Interleucina-10/imunologia , Melanoma/imunologia , Células T Matadoras Naturais/imunologia , Neutrófilos/imunologia , Proteína Amiloide A Sérica/imunologia , Animais , Linhagem Celular Tumoral , Feminino , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Neutrófilos/citologia
15.
Psychol Med ; 52(2): 292-302, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-32777197

RESUMO

BACKGROUND: For a small minority of personnel, military service can have a negative impact on their mental health. Yet no studies have assessed how the mental health of UK veterans (who served during the recent operations in Afghanistan or Iraq) compares to non-veterans, to determine if they are at a disadvantage. We examine the prevalence of mental disorders and alcohol misuse in UK veterans compared to non-veterans. METHODS: Veteran data were taken from the third phase of the King's Centre for Military Health Research cohort study (n = 2917). These data were compared with data on non-veterans taken from two large general population surveys: 2014 Adult Psychiatric Morbidity Survey (n = 5871) and wave 6 of the UK Household Longitudinal Study (UKHLS, n = 22 760). RESULTS: We found that, overall, UK veterans who served at the time of recent military operations were more likely to report a significantly higher prevalence of common mental disorders (CMD) (23% v. 16%), post-traumatic stress disorder (PTSD) (8% v. 5%) and alcohol misuse (11% v. 6%) than non-veterans. Stratifying by gender showed that the negative impact of being a veteran on mental health and alcohol misuse was restricted to male veterans. Being ill or disabled was associated with a higher prevalence of CMD and PTSD for both veterans and non-veterans. CONCLUSION: Whilst the same sociodemographic groups within the veteran and non-veteran populations seemed to have an increased risk of mental health problems (e.g. those who were unemployed), male veterans, in particular, appear to be at a distinct disadvantage compared to those who have never served.


Assuntos
Alcoolismo , Transtornos Mentais , Militares , Transtornos de Estresse Pós-Traumáticos , Veteranos , Adulto , Alcoolismo/epidemiologia , Estudos de Coortes , Humanos , Guerra do Iraque 2003-2011 , Estudos Longitudinais , Masculino , Transtornos Mentais/epidemiologia , Saúde Mental , Militares/psicologia , Transtornos de Estresse Pós-Traumáticos/epidemiologia , Transtornos de Estresse Pós-Traumáticos/psicologia , Reino Unido/epidemiologia , Veteranos/psicologia
16.
Soc Psychiatry Psychiatr Epidemiol ; 57(9): 1795-1805, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35661897

RESUMO

PURPOSE: Risk of violence by UK military personnel, both towards non-family and family, has been found to be higher post-deployment. However, no UK research to date has attempted to examine relationship conflict and intimate partner violence (IPV) in this period. This study estimated the prevalence of and risk factors for post-deployment relationship conflict and partner violence in UK military personnel. METHODS: We utilised data on military personnel who had deployed to Iraq and/or Afghanistan (n = 5437), drawn from a large cohort study into the health and well-being of UK military personnel. RESULTS: 34.7% reported relationship conflict (arguing with partner) and 3.4% reported perpetrating physical IPV post-deployment. Males were more likely than females to report relationship conflict. There were similar rates of self-reported physical IPV perpetration among males and females. Among our male sample, factors associated with both relationship conflict and physical IPV perpetration post-deployment included being in the Army compared with the Royal Air Force, higher levels of childhood adversity, higher levels of military trauma exposure and recent mental health and alcohol misuse problems. Being over 40 at time of deployment (vs being under 25) and having deployed in a combat role were also associated with relationship conflict, but not physical IPV perpetration. CONCLUSIONS: Deployment-related variables and mental health and alcohol misuse problems were found to be key factors associated with post-deployment relationship conflict and IPV. Services providing health or welfare support to military personnel must collaborate with mental health services and consider history of deployment, and particularly deployment-related trauma, in their assessments to improve identification and management of intimate partner violence and abuse in military communities.


Assuntos
Alcoolismo , Violência por Parceiro Íntimo , Militares , Afeganistão , Alcoolismo/epidemiologia , Criança , Estudos de Coortes , Feminino , Humanos , Iraque , Guerra do Iraque 2003-2011 , Masculino , Militares/psicologia , Fatores de Risco , Violência/psicologia
17.
Pharm Stat ; 21(4): 706-711, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35819120

RESUMO

In this article we look back over the last few decades and consider the progress made against the barriers that Andy Grieve has identified that may be holding statisticians back. We highlight some examples from his career where he leads the way in showing how we may overcome obstacles to enable statisticians to 'count' and assess whether anything has now changed for pharmaceutical statisticians.


Assuntos
Pesquisadores , Humanos
18.
J Strength Cond Res ; 36(3): 738-746, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-34132221

RESUMO

ABSTRACT: Merrigan, JJ, O'Toole, KB, Wutzke, CJ, and Jones, MT. Kinetic and kinematic analysis of various drop jump performances in army reserve officer training corps cadets. J Strength Cond Res 36(3): 738-746, 2022-The purpose was to examine effects of sex, drop height, and external loads on drop jump mechanics in Reserve Officer Training Corps cadets and whether findings were associated with strength. Males (n = 14) and females (n = 12) completed maximal isokinetic concentric (slow-C and fast-C) and eccentric (slow-E and fast-E) knee extensions and flexions at 60°·s-1 and 180°·s-1. After 72 hours, 3 drop jumps were performed under 3 conditions (i.e., 30 cm unloaded [30UL], 30 cm loaded 15 kg [30L], and 60 cm unloaded [60UL]). No sex × condition interactions existed for any metric (p > 0.05). The 30L condition resulted in slower eccentric and concentric center of mass (COM) and angular velocities, reduced concentric vertical ground reaction forces (vGRF), and lower jump performances. Although 60UL resulted in greater eccentric COM and angular velocities, peak vGRF, impulse, and rate of force development (p < 0.008), no differences existed in jump performances. Males had faster COM and angular concentric velocities and smaller knee valgus angles, but no different vGRF compared with females. The change in the peak hip angle, because of 60UL, was associated with knee extension eccentric and concentric strength, whereas changes in knee angles were associated with eccentric strength. Likewise, eccentric strength influenced the effects of 30L on landing vGRF more so than concentric strength. Initial strength training is recommended, specifically emphasizing eccentric actions, before performing loaded (15 kg) drop jumps to reduce the increase of landing forces. However, caution may be required when performing drops from 60 cm because of increased forces, although no decline in jump performances were noted.


Assuntos
Treinamento Resistido , Fenômenos Biomecânicos , Feminino , Humanos , Joelho , Articulação do Joelho , Masculino , Força Muscular , Amplitude de Movimento Articular , Treinamento Resistido/métodos
19.
J Strength Cond Res ; 36(7): 1810-1818, 2022 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-33021579

RESUMO

ABSTRACT: Merrigan, JJ, Jones, MT, Malecek, J, Padecky, J, Omcirk, D, Xu, N, Peñailillo, L, and Tufano, JJ. Comparison of traditional and rest-redistribution sets on indirect markers of muscle damage following eccentric exercise. J Strength Cond Res 36(7): 1810-1818, 2022-The purpose was to investigate the effect of rest-redistribution (RR) on muscle damage after eccentric knee extensions. After 2 weeks of eccentric familiarization, 11 resistance-trained men performed 2 work-matched isokinetic unilateral eccentric knee extension protocols at 60°·s-1 using a crossover design, separated by 7 days. Subjects performed 40 repetitions with 285 seconds of rest using traditional sets (TS; 4 sets of 10 with 95 seconds of interset rest) and RR (RR; 20 sets of 2 with 15 seconds of interset rest). Muscle morphology, tensiomyography, range of motion, perceived soreness, and strength were measured before and 0, 24, 48, 72, and 96 hour after RR and TS. There were no protocol × time interactions (p < 0.05). When collapsed across protocol and compared to baseline, echo intensity of the proximal vastus lateralis was 7 ± 9% greater at 0 hour (p = 0.042), echo intensity of the distal vastus lateralis was 6 ± 7% and 9 ± 7% greater at 0 hour (p = 0.048) and 24 hour (p < 0.001), respectively, and passive ROM was 2 ± 1% lower at 48 hour (p = 0.043) after exercise. No other differences existed over time for any other variable. Thus, contrary to concentric performance where RR likely plays a large role in maintaining performance, RR during eccentric isokinetic resistance training does not strongly influence exercise performance and indications of subsequent muscle damage.


Assuntos
Músculo Esquelético , Treinamento Resistido , Biomarcadores , Exercício Físico/fisiologia , Humanos , Masculino , Força Muscular , Músculo Esquelético/fisiologia , Músculo Quadríceps/diagnóstico por imagem , Amplitude de Movimento Articular , Treinamento Resistido/métodos
20.
J Pediatr ; 235: 277-280, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33894260

RESUMO

Civic engagement, including voting, has been linked to health outcomes for adults. Here, we found that census tract-level voter participation rates are significantly associated with pediatric inpatient bed-day rates even after adjustment for socioeconomic deprivation. Such links suggest that promotion of voting participation could be warranted in healthcare settings.


Assuntos
Hospitalização/estatística & dados numéricos , Política , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Ohio , Avaliação de Resultados em Cuidados de Saúde , Estudos Retrospectivos
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