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BACKGROUND: Premutations in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene, defined as between 55 and 200 CGGs, have been implicated in fragile X-associated primary ovarian insufficiency (FXPOI). Only 20% of female premutation carriers develop early ovulatory dysfunction, the reason for this incomplete penetrance is unknown. This study validated the mathematical model in premutation alleles, after assigning each allele a score representing allelic complexity. Subsequently, allelic scores were used to investigate the impact of allele complexity on age at amenorrhea for 58 premutation cases (116 alleles) previously published. METHODS: The allelic score was determined using a formula previously described by our group. The impact of each allelic score on age at amenorrhea was analyzed using Pearson's test and a contour plot generated to visualize the effect. RESULTS: Correlation of allelic score revealed two distinct complexity behaviors in premutation alleles. No significant correlation was observed between the allelic score of premutation alleles and age at amenorrhea. The same lack of significant correlation was observed regarding normal-sized alleles, despite a nearly significant trend. CONCLUSIONS: Our results suggest that the use of allelic scores combination have the potential to explain female infertility, namely the development of FXPOI, or ovarian dysfunction, despite the lack of correlation with age at amenorrhea. Such a finding is of great clinical significance for early identification of females at risk of ovulatory dysfunction, enhancement of fertility preservation techniques, and increasing the probability for a successful pregnancy in females with premutations. Additional investigation is necessary to validate this hypothesis.
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Alelos , Amenorreia , Proteína do X Frágil da Deficiência Intelectual , Insuficiência Ovariana Primária , Humanos , Feminino , Proteína do X Frágil da Deficiência Intelectual/genética , Amenorreia/genética , Insuficiência Ovariana Primária/genética , Adulto , Heterozigoto , Mutação , Síndrome do Cromossomo X Frágil/genética , Fatores Etários , Adulto Jovem , AdolescenteRESUMO
OBJECTIVES: This investigation aimed to assess the optimal timing for lip repair in children with cleft lip and palate via 3D anthropometric analysis to evaluate their maxillofacial structures. METHODS: The sample comprised 252 digitized dental models, divided into groups according to the following timing of lip repair: G1 (n = 50): 3 months; G2 (n = 50): 5 and 6 months; G3 (n = 26): 8 and 10 months. Models were evaluated at two-time points: T1: before lip repair; T2: at 5 years of age. Linear measurements, area, and Atack index were analyzed. RESULTS: At T1, the intergroup analysis revealed that G1 had statistically significant lower means of I-C', I-C, C-C', and the sum of the segment areas compared to G2 (p = 0.0140, p = 0.0082, p = 0.0004, p < 0.0001, respectively). In addition, there was a statistically significant difference when comparing the cleft area between G2 and G3 (p = 0.0346). At T2, the intergroup analysis revealed that G1 presented a statistically significant mean I-C' compared to G3 (p = 0.0461). In the I-CC' length analysis, G1 and G3 showed higher means when compared to G2 (p = 0.0039). The I-T' measurement was statistically higher in G1 than in G2 (p = 0.0251). In the intergroup growth rate analysis, G1 and G2 showed statistically significant differences in the I-C' measurement compared to G3 (p = 0.0003). In the analysis of the Atack index, there was a statistically significant difference between G1 and the other sample sets (p < 0.0001). CONCLUSION: Children who underwent surgery later showed better results in terms of the growth and development of the dental arches.
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Craniofacial development begins during the fourth week of intrauterine life (IUL) [...].
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ABSTRACT Objective: To evaluate the clinical and radiographic response of pulp-dentin complex after selective caries removal with or without pulp lining in primary teeth. Material and Methods: Twenty-four primary molars with deep occlusal caries lesions and without pulpal alterations were selected from children, both genders, aged between 5 and 9 years old. After selective caries removal, the teeth were divided into three groups: without cavity liner (Group I), calcium hydroxide cement - CH (Group II), and Mineral trioxide aggregate - MTA (Group III). The final restoration was performed with resin-modified glass ionomer cement. Clinical and radiographic assessments were conducted at 6-month follow-up. The Kappa test determined intraexaminer reliability. Fisher's exact test evaluated intergroup comparisons (p<0.05). Results: All teeth showed clinical and radiographic success at the 6-month follow-up without statistically significant differences (p>0.05). Conclusion: Selective caries removal without cavity lining was acceptable for deep caries lesions in primary teeth.
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Humanos , Masculino , Feminino , Pré-Escolar , Criança , Dente Decíduo , Radiografia Dentária/instrumentação , Cárie Dentária/prevenção & controle , Capeamento da Polpa Dentária , Interpretação Estatística de DadosRESUMO
Aim: This study aimed to investigate the occurrence of enamelin gene (ENAM) single nucleotide polymorphisms (SNP) and ENAM polymorphism association with dental anomalies (DA) in individuals with unilateral or bilateral cleft lip and palate (CLP). Methods: Saliva samples were collected from 147 individuals aged between 6 and 15 years-old, both genders, and divided into 4 groups: Group 1 (G1) - CLP and DA; Group 2 (G2) - CLP without DA; Group 3 (G3) - without CLP with DA; Group 4 (G4) - without CLP and DA. The genomic DNA was extracted from saliva samples and the following ENAM SNPs markers were genotyped: rs3796703, rs3796704, rs3796705, rs7671281, rs2609428, and rs35951442. Fisher exact and Pearson's Chi-square tests statistically analyzed the results (α=5%). Results: Individuals without CLP with DA (Group 3 - 19.2%) showed statistically higher prevalence of SNP rs2609428 heterozygotes (p=0.006) than individuals with CLP and DA (Group 1 - 0%). Individuals without CLP (10%) exhibited statistically higher prevalence of mutated heterozygotes/homozygous (p=0.028) than in individuals with CLP (1.3%). Conclusion: SNP rs2609428 marker of ENAM gene may be associated with dental anomalies in individuals without cleft lip and palate
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Humanos , Masculino , Feminino , Criança , Adolescente , Anormalidades Dentárias , Proteínas da Matriz Extracelular , Fenda Labial , Fissura Palatina , Polimorfismo de Nucleotídeo ÚnicoRESUMO
Objetivo: Avaliar a aceitabilidade e o conhecimento de estudantes de graduação em Odontologia e cirurgiões-dentistas sobre a remoção seletiva de tecido cariado (RSTC). Materiais e Métodos: Participaram do estudo graduandos do terceiro e quarto ano de Odontologia (Grupo 1) e egressos de um Centro Hospitalar de Odontologia (Grupo 2). Os participantes responderam de forma anônima e confidencial um questionário validado contendo onze questões sobre diagnóstico e manejo de lesões cariosas profundas. Teste qui-quadrado de Pearson e regressão logística multivariada foram aplicados (p<0.05). Resultados: A amostra total foi composta por 146 participantes. Destes, 81.5% eram do sexo feminino; 52.05% eram graduados e a faixa etária mais prevalente foi de 18 a 29 anos (85.62%). Sessenta e nove participantes escolheram o tratamento expectante (p=0.027). A análise de regressão logística mostrou diferenças estatisticamente significativas. Os participantes que consideraram a parede pulpar úmida têm aproximadamente oito vezes mais chances de escolha pelo tratamento invasivo (p=0.028). Aqueles que escolheram o tratamento endodôntico como opção de sobrevida em dois anos têm três vezes mais chances de optar pelo tratamento invasivo (p=0.032). Aqueles que afirmaram que a dentina cariada próxima à polpa não deveria ser removida tiveram quase três vezes mais chances de optar por tratamentos minimamente invasivos (p=0.031). Discussão: Estudos com questionários podem ser ferramentas úteis para detectar se estudantes e cirurgiões-dentistas estão seguindo as evidências mais atuais para o tratamento de lesões cariosas profundas. Conclusão: Os participantes tinham certo nível de conhecimento sobre RSTC, mas a aceitabilidade da técnica carecia de consenso.
Aim: The aim of this study was to evaluate the acceptability and knowledge of undergraduate dental students and dentists on selective caries tissue removal (SCTR). Materials and Methods: Third- and fourth-year Dentistry undergraduates (Group 1) and graduates working in a Hospital Dentistry Center (Group 2) were included in the study. Participants anonymously and confidentially answered a validated questionnaire containing eleven questions on the diagnosis and management of deep caries lesions. Pearson's Chi-square test and multivariate logistic regression compared the answers (p<0.05). Results: Total sample comprised 146 participants. Of these, 81.5% were female; 52.05% were graduates and the most prevalent age group was 18-29 years old (85.62%). Sixty-nine participants chose stepwise caries removal (p=0.027). The logistic regression analysis showed statistically significant differences. The participants who considered pulp wall moist have approximately eight times more likelihood to choose an invasive treatment (p=0.028). Those who chose endodontic treatment as an option for two-year survival have three times more likelihood to choose an invasive treatment (p=0.032). Those who affirmed that the carious dentin close to the pulp should not be removed had almost three times more likelihood to choose minimally invasive treatments (p=0.031). Discussion: Studies with questionnaires can be useful tools to detect whether the students and dentists are following the most current evidences to treat deep carious lesions. Conclusion: The participants had certain level of knowledge on SCTR, but the technique acceptability lacked consensus.
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Aim: to evaluate the surgical effects of two rehabilitation protocols on dental arch occlusion of 5-year-old children with or without cleft lip and palate. Methods: this is a retrospective longitudinal study the sample comprised 45 digitized dental casts divided into followed groups: Group 1 (G1) children who underwent to cheiloplasty (Millard technique) at 3 months and to one-stage palatoplasty (von Langenbeck technique) at 12 months; Group 2 (G2) children who underwent to cheiloplasty (Millard technique) and two-stage palatoplasty (Hans Pichler technique for hard palate closure) at 3 months and at 12 months to soft palate closure (Sommerlad technique); and Group 3 (G3) children without craniofacial anomalies. Linear measurements, area, and occlusion were evaluated by stereophotogrammetry software. Shapiro-Wilk test was used to verify normality. ANOVA followed by posthoc Tukey test and Kruskal-Wallis followed by posthoc Dunn tests were used to compared groups. Results: For the measures intercanine distance (C-C'), anterior length of dental arch (I-CC'), and total length of the dental arch (IMM'), there were statistical differences between G1x G3 and G2xG3, the mean was smaller for G1 and G2. No statistically significant differences occurred in the intermolar distance and in the dental arch area among groups. The occlusion analysis revealed significant difference in the comparison of the three groups (p=0.0004). Conclusion: The surgical effects of two rehabilitation protocols affected the occlusion and the development of the anterior region of the maxilla of children with oral clefts when compared to children without oral clefts.
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Humanos , Masculino , Feminino , Pré-Escolar , Criança , Cirurgia Bucal , Protocolos Clínicos , Fenda Labial , Fissura Palatina , Arco Dental , Oclusão DentáriaRESUMO
Abstract Oral cleft surgical repairs are performed using different techniques worldwide. Objective To evaluate and compare the development of the dental arches of children with unilateral cleft lip and palate before and after the primary surgeries performed with different techniques at the first months and six years of life. Methodology This is a retrospective longitudinal study. The sample comprised 56 dental casts divided int the following groups: Group 1 (G1) - cheiloplasty (Millard technique) at three months and one-step palatoplasty (von Langenbeck technique) at 12 months; and Group 2 (G2) - cheiloplasty (Millard technique) and two-step palatoplasty: anterior hard palate closure (Hans Pichler technique) at three months and posterior soft palate closure (Sommerlad technique) at 12 months. The digitized dental casts were evaluated at three months - pre-surgical (T1) and six years of life- post-surgical (T2). The following linear measurements were analyzed: intercanine (C-C'), intertuberosity (T-T') distances; anterior dental arch (I-CC'), anterior intersegment (I-C'), and total arch (I-TT') lengths. The palate area was also measured. Parametric and non-parametric tests were applied (p<0.05). Results In G1, the intragroup comparison showed statistically significant smaller I-CC' and I-C' at T2 (p=0.001 and p<0.001, respectively), while T-T', I-TT', and area comparisons were significantly greater (p<0.001, p=0.002, and p<0.001, respectively). In G2, the intragroup comparison exhibited statistically significant smaller C-C' and I-C' at T2 (p=0.004, for both), whereas T-T', I-TT' and area comparisons were significantly greater (p<0.001, p=0.004, and p<0.001, respectively). At T2, the intergroup analysis revealed that G1 had a statistically significant smaller I-CC' (p=0.014). The analysis of the intergroup differences (∆=T2-T1) showed that G1 had a statistically smaller I-CC' (p=0.043). Conclusion The two-step palatoplasty showed a more favorable prognosis for the maxillary growth than one-step palatoplasty in children with oral clefts.
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Objective: Compare the palatal volume in children with unilateral cleft lip and palate before and after two surgical protocols. Material and Methods: Retrospective data collection was performed in a specialized hospital. The sample comprised 120 digitized dental models divided into, Group 1 (G1) participants submitted to cheiloplasty at 3 months (Millard technique) and one-step palatoplasty at 12 months (von Langenbeck technique); Group 2 (G2) participants submitted to cheiloplasty (Millard technique) and hard palate closure (Hans Pichler technique) at 3 months and soft palate closure at 12 months (Sommerlad technique). The dental models were evaluated at Time 1 (T1): before primary plastic surgeries, Time 2 (T2): 1st post-surgical phase, and Time 3 (T3): 2nd post-surgical phase. The volume was measured through stereophotogrammetry system software. Parametric and non-parametric statistical tests were applied (α=5%). Results: The intragroup analysis revealed that G1 had a statistically significant increase in volume at T2 followed by a reduction at T3 (p=0.003); G2 showed a statistically significant increase of dental arch volume between T1 and T2 (p=0.001). There was no statistically significant difference in the intergroup and gender analyses (p>0.05). Conclusion: The surgical protocol influenced the palatal volume of children with unilateral cleft lip and palate. This study suggested that two-step palatoplasty protocol has a tendency to be more appropriate.(AU)
Objetivo: Comparar o volume palatino em crianças com fissura unilateral de lábio e palato antes e após dois protocolos cirúrgicos. Material e Métodos: A coleta de dados retrospectiva foi efetuada em um hospital especializado. A amostra foi composta por 120 modelos dentários digitalizados divididos em, Grupo 1 (G1) participantes submetidos a queiloplastia aos 3 meses de vida (técnida de Millard) e a palatoplastia em única etapa aos 12 meses (técnica de von Langenbeck); Grupo 2 (G2) participantes submetidos a queiloplastia (técnica de Millard) e fechamento do palato duro (técnica de Hans Pichler) aos 3 meses de vida e fechamento do palate mole aos 12 meses (técnica de Sommerlad). Os modelos dentários foram avaliados em Tempo 1 (T1): antes das cirurgias plásticas primárias, Tempo 2 (T2):1ª fase pós-cirúrgica e Tempo 3 (T3): 2ª fase pós-cirúrgico. O volume foi mensurado por meio do software do sistema de estereofotogrametria. Testes estatísticos paramétricos e não-paramétricos foram utilizados (α=5%). Resultados: As análises intragrupos indicaram que G1 apresentou aumento estatisticamente significante em T2 seguido de redução em T3 (p=0.003). G2 apresentou crescimento estatisticamente significativo do volume palatino entre T1 e T2 (p=0.001). Não houve diferença estatisticamente significante nas análises intergrupos e entre gêneros (p>0.05). Conclusão: O protocolo cirúrgico influenciou o volume palatino das crianças com fissura unilateral de lábio e palato. Este estudo sugeriu que o protocolo da palatoplastia em duas etapas possui uma tendência de ser mais apropriado.(AU)
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Fenda Labial , Fissura Palatina , Procedimentos Cirúrgicos Bucais , Imageamento Tridimensional , Arco DentalRESUMO
Este artigo descreve a dificuldade em diagnosticar um cisto folicular inflamatório na área anterior da mandíbula em um menino com dentinogênese imperfeita tipo I (DI-1). Um menino de 6 anos de idade, com DI-1, procurou tratamento devido ao comprometimento estético. O exame radiográfico revelou uma lesão periapical envolvendo os dentes decíduos incisivo central e lateral direitos. Esses dentes foram extraídos sem intercorrências. Após três meses, a criança se queixou de dor em um edema de cor azulada na mesma área. O diagnóstico diferencial foi de cisto folicular e a lesão foi acompanhada. Como os sinais e sintomas persistiram, o tratamento de escolha foi a descompressão da lesão, seguido por irrigação abundante e curetagem das paredes da lesão. O acompanhamento clínico e radiográfico, mostrou, após 6 meses, remissão da lesão, reparo ósseo, e erupção ativa dos incisivos permanentes. As características incomuns deste caso, fizeram com que o diagnóstico de cisto folicular inflamatório fosse dificultado.
This article reports the difficulties in diagnosing an inflammatory follicular cyst in the mandibular anterior area of a boy with type 1 dentinogenesis imperfecta (DI-1). A 6-year-old boy, with DI-1, sought treatment due to esthetic complaints. The radiographic examination revealed a periapical lesion involving the right primary central and lateral incisors. These teeth were extracted with no complications. After three months, the boy complained of pain in a blue-black edema in the same area. The differential diagnosis was of follicular cyst and the lesion was followed-up. As the signs and symptoms persisted, the treatment of choice was to decompress the lesion, followed by copious irrigation, and lesion's wall curettage. After six months, the clinical and radiographic follow-up showed lesion remission, bone repair, and active eruption of permanent incisors. The uncommon characteristics of the case make the diagnosis of inflammatory follicular cyst difficult.
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Cisto Radicular , Cisto Odontogênico Calcificante , Dentinogênese ImperfeitaRESUMO
Abstract Oral health problems can influence people's Quality of Life (QoL) because of pain, discomfort, limitations, and other esthetics problems, affecting their social life, feeding, daily activities, and the individual's well-being. Objective: To compare oral health-related quality of life (OHRQoL) of children with and without oral clefts and their families. Materials and Methods: 121 children aged from 2 to 6 years, from both sexes, enrolled in the treatment routine of the Pediatric Dentistry Clinics of a Dental School and a Hospital for Cleft Treatment were divided into two groups: Group 1 - children with cleft lip and palate; Group 2 - children without cleft lip and palate. The OHRQoL was assessed using the validated Portuguese version of the Early Childhood Oral Health Impact Scale (B-ECOHIS). The questionnaire was answered individually, only once, at a private place. Mann-Whitney U test was used to verify differences between groups. Spearman's Rho test was used to associate sex and age with quality of life. The level of significance was set at 5% (p<0.05). Results: According to the parents' perception on the OHRQoL of children with and without cleft lip and palate, oral health of children with oral clefts (Group 1) had a statistically significant impact on OHRQoL. The correlation of sex with impact on OHRQoL did not show statistically significant differences. On the other hand, the higher the age the higher the impact on QoL. Conclusions: The group comparison revealed that the cleft lip and palate negatively impacted on OHRQoL of 2 to 6-year-old children and their parents.
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Humanos , Masculino , Feminino , Pré-Escolar , Criança , Qualidade de Vida , Saúde Bucal/estatística & dados numéricos , Fenda Labial/fisiopatologia , Fissura Palatina/fisiopatologia , Perfil de Impacto da Doença , Família/psicologia , Estudos de Casos e Controles , Fatores Sexuais , Inquéritos e Questionários , Fenda Labial/psicologia , Fissura Palatina/psicologia , Fatores Etários , Estatísticas não ParamétricasRESUMO
Abstract This study aimed at monitoring the maxillary growth of children with cleft lip/palate in the first two years of life, and to evaluate the effects of primary surgeries on dental arch dimensions. The sample consisted of the three-dimensional digital models of 25 subjects with unilateral complete cleft lip and palate (UCLP) and 29 subjects with isolated cleft palate (CP). Maxillary arch dimensions were measured at 3 months (before lip repair), 1 year (before palate repair), and at 2 years of age. Student’s ttest was used for comparison between the groups. Repeated measures ANOVA followed by Tukey’s test was used to compare different treatment phases in the UCLP group. Paired ttest was used to compare different treatment phases in the CP group. P<0.05 was considered statistically significant. Decreased intercanine distance and anterior arch length were observed after lip repair in UCLP. After palate repair, maxillary dimensions increased significantly, except for the intercanine distance in UCLP and the intertuberosity distance in both groups. At the time of palate repair and at two years of age, the maxillary dimensions were very similar in both groups. It can be concluded that the maxillary arches of children with UCLP and CP changed as a result of primary surgery.
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Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Fenda Labial/cirurgia , Fissura Palatina/cirurgia , Imageamento Tridimensional/métodos , Arco Dental/crescimento & desenvolvimento , Maxila/crescimento & desenvolvimento , Valores de Referência , Fatores de Tempo , Cefalometria , Análise de Variância , Fenda Labial/reabilitação , Fissura Palatina/reabilitação , Fatores Etários , Resultado do Tratamento , Arco Dental/patologia , Pontos de Referência Anatômicos , Ilustração MédicaRESUMO
This cross-sectional study aimed to evaluate the impact of malocclusion on the oral health-related quality of life (OHRQoL) in Brazilian children with non-syndromic oral cleft sat tertiary craniofacial center. Material and Methods: Sixty-nine children with non-syndromicoral clefts, aged between 8 and 10 years, were selected and divided into groups according to the cleft type: Group 1 Children with complete unilateral cleft lip and alveolus; Group 2 Children with unilateral cleft lip and palate; Group 3 Children with cleft palate. Each child ans wered the Child Perceptions Questionnaire 8-10 (CPQ8-10) which is a multiple-choice questionnaire, with 29 questions on the impact of oral diseases on the OHRQoL. Then, a visual examination of dental occlusion was carried out. Kruskal-Wallis and Mann-Whitney tests were used to determine statistical significant differences among groups(p<0.05). Results: No statistically significant differences were verified for the impact of cleft type (p=0.895) and malocclusion (p=0.528) on HRQoL of Brazilian children with oral clefts. Conclusion: The malocclusion did not impact onthe OHRQoL of 8-10 year-old children with nonsyndromicclefts...
Este estudo transversal avaliou o impacto da má oclusão sobre a qualidade de vida relacionada à saúde oral de crianças brasileiras com fissuras labiopalatina não sindrômicas de um centro de tratamento craniofacial. Material e Métodos: Sessenta e nove crianças com fissurelabiopalatina não sindrômica, com idades entre oito e dez anos, foram selecionadas e divididas em grupos de acordo com o tipo de fissure: Grupo 1 Crianças com fissura completa de lábio e alvéolo; Grupo 2 Crianças com fissura completa de lábio e palato; Grupo 3 Crianças com fissura de palato. Cada criança respondeu o Child Perceptions Questionnaire 8-10 (CPQ 8-10) que é um questionário de múltipla escolha, com 29 perguntas sobre o impacto das doenças orais sobre a qualidade devida. Em seguida, o exame visual da oclusão foi realizado. Os testes de Kruskal-Wallis and Mann-Whitney foram usados para determinar as diferenças estatisticamente significativas entre os grupos (p<0,05). Resultados: Diferenças estatisticamente significativas não foram verificadas para o impacto do tipo de fissura (p=0,895) e má oclusão (p=0,528) na qualidade de vida de crianças brasileiras com fissuras labiopalatinas. Conclusão: A má oclusão não teve impacto sobre a qualidade de vida de crianças com idade entre oito a dez anos com fissure de lábio e palato não sindrômica...
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Criança , Fenda Labial , Fissura Palatina , Qualidade de Vida , Saúde BucalRESUMO
The aim of this study was to measure and compare the dimensions of the dental arches on three-dimensional digital study models in children with and without cleft lip and palate before the primary surgery. The sample consisted of 223 digital models of children aged 3-9 months, divided into 5 groups: without craniofacial deformities, unilateral and bilateral incomplete cleft lip and alveolus, unilateral and bilateral complete cleft lip and alveolus, unilateral cleft lip and palate, and bilateral cleft lip and palate. Dental casts of the maxillary dental arches of the children were used. The dental casts underwent a process of scanning through 3D scanner and the measurements used for the correlation among groups were made on the scanned images. Statistical analysis was performed by t test and ANOVA followed by Tukey test. The results showed that the intercanine distance and anterior cleft width was wider in children with unilateral cleft lip and palate. The intertuberosity distances and posterior cleft width was wider in children with bilateral cleft lip and palate among the groups. Children with cleft lip and palate before the primary surgery had wider maxillary arch dimensions than the children without cleft lip and palate.
O propósito deste trabalho foi mensurar e comparar as dimensões dos arcos dentários em modelos digitais tridimensionais de crianças com ou sem fissuras de lábio e palato antes das cirurgias primárias. A amostra foi composta de 223 modelos de gesso de crianças, de 3 a 9 meses, divididas em 5 grupos: sem deformidades craniofaciais, fissura pré-forame incompleta, fissura pré-forame completa, fissura transforame unilateral e fissura transforame bilateral. Modelos de gesso dos arcos dentários superiores das crianças foram utilizados para avaliação. Os modelos passaram por um processo de digitalização, por meio de escâner 3D e as medidas utilizadas para a correlação entre os grupos foram realizadas diretamente nas imagens escaneadas. A análise estatística foi realizada por meio do teste t e ANOVA seguido pelo teste de Tukey. Os resultados mostraram que a distância intercaninos e a amplitude anterior da fissura foram maiores nas crianças com fissura transforame unilateral. A distância intertuberosidades e a amplitude posterior da fissura foi maior nas com fissura transforame bilateral entre os grupos estudados. As crianças com fissura de lábio e palato apresentam as dimensões dos arcos maxilares maiores que as crianças sem fissura labiopalatina antes das cirurgias primárias.
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Humanos , Masculino , Feminino , Lactente , Fenda Labial/patologia , Fissura Palatina/patologia , Arco Dental/anatomia & histologia , Reprodutibilidade dos TestesRESUMO
O objetivo deste estudo foi relatar o uso do sistema CVDentus® em dois casos clínicos de crianças com fissuras labiopalatinas e cárie dentária. Demonstração da técnica de utilização do sistema CVDentus®, associada à cureta para remover a cárie dentária das paredes circundantes. Os dentes foram restaurados com Cimento de Ionômero de Vidro modificado por Resina. O acabamento e o polimento foram realizados com pontas diamantadas douradas, pedra Arkansas branca e pontas de silicone. A vantagem oferecida pelo sistema CVDentus® está diretamente relacionada a um maior conforto ao profissional e paciente, pois promove menor ruído, vibração e sensibilidade dolorosa, superando, assim, um dos maiores desafios da odontopediatria. O sistema CVDentus® parece ser uma alternativa promissora, sobretudo para pacientes com fissura labiopalatina mais agitados, ansiosos, cujos efeitos negativos dos instrumentos rotatórios convencionais podem tornar mais difícil o controle de suas condutas durante o atendimento odontológico.
The aim of this study was report the use of the system CVDentus® in two clinical cases of children with cleft lip and palate and dental caries. Technique demonstration of using the system CVDentus®, combined with a curette to remove caries of the cavity walls. The teeth were restored with glass-ionomer cement modified by resin. The finishing and polishing were performed (were done or were conducted) with diamond gold, white Arkansas stone and silicone tips. New technologies have emerged in the dental market, in order to facilitate the removal of carie tissue preserving the most of tooth structure. The system CVDentus® promotes reduced noise, vibration and pain sensitivity and consequently increased comfort to the patient and professional. The comfort provided is directly related to good behavior, thus overcoming one of the biggest challenges of pediatric dentistry. The CVDentus ® system seems to be a promissory alternative, especially for patients with cleft lip and palate more agitated, anxious, whose negative effects of conventional rotary instruments may make it harder to control their behavior during dental treatment.
RESUMO
Intraperitoneal adhesions usually are formed after abdominal surgeries and may cause technical difficulties during surgical intervention, chronic abdominal pain and severe obstructions of the gastrointestinal tract. The current study aimed to evaluate the efficacy of methylene blue (MB) 1% solution on the prevention of intraperitoneal postsurgical adhesion formation in a canine surgical trauma model. Twenty bitches were submitted to falciform ligament resection, omentectomy, ovariohysterectomy and scarification of a colonic segment. Prior to abdominal closure, 10 bitches received 1mg kg-1 MB intraperitoneally (MB group) and 10 bitches received no treatment (control group, CT). On the 15th postoperative day the bitches were submitted to laparoscopy to assess adhesions. The mean adhesion scores were 13.9 (±5.6) for MB group and 20.5 (±6.4) for the CT group (P=0,043). In conclusion, the 1% MB solution was efficient on the prevention of intraperitoneal postoperative adhesion formation in bitches, especially those involving the colonic serosa.
Aderências intraperitoneais se formam frequentemente após cirurgias abdominais, podendo causar dificuldades técnicas durante intervenções cirúrgicas, dor abdominal crônica e obstrução grave do trato gastrintestinal. O objetivo do presente estudo foi avaliar a eficácia da solução de azul de metileno (MB) a 1% na prevenção da formação de aderências intraperitoneais em um modelo experimental de trauma cirúrgico abdominal em caninos. Vinte cadelas foram submetidas à ressecção do ligamento falciforme, omentectomia, ovário-histerectomia e escarificação da serosa de um segmento de cólon. Antes da síntese abdominal, 10 cadelas receberam 1mg kg-1 de MB a 1% via intraperitoneal (grupo MB) e 10 cadelas não receberam tratamento (grupo controle, CT). No 15o dia pós-operatório, as cadelas foram submetidas à laparoscopia para avaliação da formação de aderências. Os escores de formação de aderências foram 13,8 (±5,6) para o grupo MB e 20,5 (±6,4) para o grupo CT (P=0,043). A solução de azul de metileno a 1% foi eficaz na prevenção da formação de aderências intraperitoneais pós-cirúrgicas em cadelas, sobretudo nas relacionadas à serosa do cólon.
RESUMO
Trata do desenvolvimento de práticas de avaliação de agências reguladoras abertas à participação dos diferentes públicos afetados, que estimulem a transparência do processo decisório e não inibam a participação de setores privados na oferta de serviços de relevância social. Aprecia as dimensões relevantes da avaliação à luz de contribuições selecionadas na literatura estrangeira. Identifica desafios a serem enfrentados pelas agências e pela sociedade brasileira.