A multirater perspective on personality and performance: An empirical examination of the trait-reputation-identity model.

Organizational scientists have historically assessed personality via self-reports, but there is a growing recognition that personality ratings from observers offer superior prediction of job performance compared to targets' self-reports. Yet, the origin of these differences remains unclear: do observers show predictive validity advantages (a) because they have a clearer lens into how targets' thoughts, feelings, and desires translate to their behaviors (traits), (b) because they infer personality from how targets characteristically adapt their behaviors to situations (reputation), or (c) because they omit targets' unexpressed, internal aspects of personality (identity)? With a sample of 422 cadets at a highly selective military educational institute in South Korea, we applied (McAbee & Connelly, 2016) Trait-Reputation-Identity (TRI) Model to decompose consensus and discrepancy in multirater personality data. The variance associated with reputations (the unique personality insights held by observers) dominated the prediction for conscientiousness and agreeableness in predicting all criteria. Trait factors (reflecting the consensus between self- and observer-reports) were moderately related to ratings of job performance, citizenship, and grades for most theoretically aligned personality dimensions. Identity factors (targets' unique personality self-views) were generally unrelated to performance criteria, save for some modest positive relationships for conscientiousness (predicting work and academic performance) and agreeableness (predicting citizenship). These findings suggest that personality is an important determinant of success less by depicting "who employees are" (or "who they think they are") but more by describing "what employees do." We discuss the implications of these results for how multirater assessments can be built into organizational psychology research and practice. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1α.

Evidence suggests anti-tumor activities of glucosamine-hydrochloride (GS-HCl). In the present study, we investigated anti-proliferative, growth suppressive and/or pro-apoptotic effects of GS-HCl on YD-8 human oral squamous cell carcinoma (OSCC) cells. Fundamentally, treatment with GS-HCl strongly inhibited proliferation and induced apoptosis in YD-8 cells, as determined by MTS and DNA fragmentation analyses. Of further note, as measured by Western analyses, GS-HCl treatment led to activation of caspase-3, cytosolic accumulation of cytochrome c, down-regulation of Mcl-1 and HIF-1α, up-regulation of GRP78, an indicator of ER stress, and generation of ROS in YD-8 cells. Importantly, results of pharmacological inhibition studies showed that treatment with z-VAD-fmk, a pan-caspase inhibitor, but not with vitamin E, an anti-oxidant strongly blocked the GS-HCl-induced apoptosis in YD-8 cells. Analyses of additional cell culture works further revealed that GS-HCl had a strong growth suppressive effect on not only YD-8 but also YD-10B and YD-38, two other human OSCC cell lines. These findings collectively demonstrate that GS-HCl has anti-proliferative, anti-survival, and pro-apoptotic effects on YD-8 cells and the effects appear to be mediated via mechanisms associated with the mitochondrial-dependent activation of caspases, down-regulation of Mcl-1, and induction of ER stress. Considering HIF-1α as a tumor angiogenic transcription factor, the ability of GS-HCl to down-regulate HIF-1α in YD-8 cells may further support its anti-cancer property. It is thus suggested that GS-HCl may be used as a potential anti-cancer drug against human OSCC.

[A case of superior mesenteric venous thrombosis due to protein C deficiency in a patient with duodenal ulcer bleeding].

Mesenteric venous thrombosis is a clinically very rare disease, and may cause bowel infarction and gangrene. Difficulty in the diagnosis the disease due to its non-specific symptoms and low prevalence can cause a clinically fatal situation. Mesenteric venous thrombosis may be caused by both congenital and acquired factors, and protein C deficiency, which is a very rare genetic disorder, is one of many causes of mesenteric thrombosis. The authors experienced a case of mesenteric venous thrombosis caused by protein C deficiency in a patient with duodenal ulcer bleeding, so here we report a case together with literature review.