Detalhe da pesquisa
1.
Potent hydroxamate-derived compounds arrest endodyogeny of Toxoplasma gondii tachyzoites.
Exp Parasitol
; 259: 108727, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38431113
2.
Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells.
Arch Pharm (Weinheim)
; 357(2): e2300536, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37932028
3.
Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition.
Arch Pharm (Weinheim)
; 357(2): e2300426, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37991233
4.
Total synthesis and biological evaluation of histone deacetylase inhibitor WF-3161.
Org Biomol Chem
; 21(21): 4382-4387, 2023 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37194325
5.
Melatonin-vorinostat hybrid ligands show higher histone deacetylase and cancer cell growth inhibition than vorinostat.
Arch Pharm (Weinheim)
; 356(9): e2300149, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37339785
6.
Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines.
Int J Mol Sci
; 24(8)2023 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37108579
7.
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.
Chembiochem
; 23(14): e202200180, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35608330
8.
Defined stereoisomers of 2â³-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase.
Bioorg Med Chem
; 68: 116875, 2022 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35716588
9.
Kappa but not delta or mu opioid receptors form homodimers at low membrane densities.
Cell Mol Life Sci
; 78(23): 7557-7568, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34657173
10.
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.
Int J Mol Sci
; 23(14)2022 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35886887
11.
Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development.
Int J Mol Sci
; 22(8)2021 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33923831
12.
Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors.
Int J Mol Sci
; 22(11)2021 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34072837
13.
Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology.
Chembiochem
; 21(8): 1161-1166, 2020 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31692222
14.
HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)*.
Chembiochem
; 21(23): 3371-3376, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32672888
15.
Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells.
Chembiochem
; 21(16): 2329-2347, 2020 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32227662
16.
Syntheses of Thailandepsinâ B Pseudo-Natural Products: Access to New Highly Potent HDAC Inhibitors via Late-Stage Modification.
Chemistry
; 26(69): 16241-16245, 2020 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32725698
17.
Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways.
Int J Mol Sci
; 21(17)2020 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32847028
18.
Avoiding chemotherapy prescribing errors: Analysis and innovative strategies.
Cancer
; 125(9): 1547-1557, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30695105
19.
Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors.
Beilstein J Org Chem
; 15: 2170-2183, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31598174
20.
The Current State of NAD+ -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.
Med Res Rev
; 38(1): 147-200, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28094444