Detalhe da pesquisa
1.
Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide.
Chem Res Toxicol
; 27(1): 111-8, 2014 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24328261
2.
Analytical approaches for quantification of a Nrf2 pathway activator: overcoming bioanalytical challenges to support a toxicity study.
Analyst
; 139(8): 1902-12, 2014 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24563904
3.
DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.
Bioorg Med Chem
; 18(9): 3125-32, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20371184
4.
LC-MS/MS quantification of asymmetric dimethyl arginine and symmetric dimethyl arginine in plasma using surrogate matrix and derivatization with fluorescamine.
Bioanalysis
; 12(22): 1607-1619, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-33151745
5.
Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.
J Am Chem Soc
; 131(3): 1015-24, 2009 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19117394
6.
Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.
J Med Chem
; 50(22): 5485-92, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17910426
7.
Development and validation of a simple and sensitive method for quantification of levodopa and carbidopa in rat and monkey plasma using derivatization and UPLC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci
; 926: 47-53, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23548675
8.
DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2).
J Am Chem Soc
; 129(42): 12870-7, 2007 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-17900117