Detalhe da pesquisa
1.
Biocatalysis using Thermostable Cytochrome P450 Enzymes in Bacterial Membranes - Comparison of Metabolic Pathways with Human Liver Microsomes and Recombinant Human Enzymes.
Drug Metab Dispos
; 52(3): 242-251, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38176735
2.
Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates.
Mol Biol Evol
; 39(6)2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35639613
3.
Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans.
Drug Metab Dispos
; 51(4): 464-479, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36653117
4.
Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, following Administration of an Oral Radiolabeled Microtracer Dose in Humans.
Drug Metab Dispos
; 51(4): 451-463, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36639243
5.
Oxygen Surrogate Systems for Supporting Human Drug-Metabolizing Cytochrome P450 Enzymes.
Drug Metab Dispos
; 48(6): 432-437, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32238418
6.
Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents.
Bioorg Med Chem Lett
; 29(10): 1241-1245, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30879840
7.
Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes.
Chem Res Toxicol
; 28(5): 886-96, 2015 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25803559
8.
Unexpected benzimidazole ring formation from a quinoneimide species in the presence of ammonium acetate as supporting electrolyte used in the coupling of electrochemistry with mass spectrometry.
Rapid Commun Mass Spectrom
; 29(5): 456-60, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26349468
9.
Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
Bioorg Med Chem
; 23(17): 5419-32, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26264839
10.
Use of electrochemical oxidation and model peptides to study nucleophilic biological targets of reactive metabolites: the case of rimonabant.
Chem Res Toxicol
; 27(10): 1808-20, 2014 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25210840
11.
Identification and design of a novel series of MGAT2 inhibitors.
Bioorg Med Chem Lett
; 23(9): 2721-6, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23541669
12.
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold.
Bioorg Med Chem Lett
; 22(24): 7302-5, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23149230
13.
Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
J Med Chem
; 65(17): 11485-11496, 2022 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36005476
14.
In vitro metabolism of haloperidol and sila-haloperidol: new metabolic pathways resulting from carbon/silicon exchange.
Drug Metab Dispos
; 38(1): 73-83, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19812350
15.
P450-catalyzed vs. electrochemical oxidation of haloperidol studied by ultra-performance liquid chromatography/electrospray ionization mass spectrometry.
Rapid Commun Mass Spectrom
; 24(9): 1231-40, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20391593
16.
Novel metabolites of amodiaquine formed by CYP1A1 and CYP1B1: structure elucidation using electrochemistry, mass spectrometry, and NMR.
Drug Metab Dispos
; 37(3): 571-9, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19074972
17.
Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.
Chem Res Toxicol
; 21(10): 2035-41, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18788755
18.
Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies.
Chem Res Toxicol
; 21(5): 1107-19, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18419141
19.
Correction to "Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction".
J Med Chem
; 65(19): 13482, 2022 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36190771
20.
Can silicon make an excellent drug even better? An in vitro and in vivo head-to-head comparison between loperamide and its silicon analogue sila-loperamide.
ChemMedChem
; 10(5): 911-24, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25801200