Detalhe da pesquisa
1.
Structure-based design of new N-benzyl-piperidine derivatives as multitarget-directed AChE/BuChE inhibitors for Alzheimer's disease.
J Cell Biochem
; 124(11): 1734-1748, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37796142
2.
Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases.
Neurochem Res
; 45(12): 3003-3020, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33079324
3.
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease.
Molecules
; 25(14)2020 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32664425
4.
Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant.
J Enzyme Inhib Med Chem
; 34(1): 631-637, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30727776
5.
Anti-atherogenic effects of a new thienylacylhydrazone derivative, LASSBio-788, in rats fed a hypercholesterolemic diet.
J Pharmacol Sci
; 123(1): 47-57, 2013 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24018841
6.
Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives.
Molecules
; 18(10): 11683-704, 2013 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24071978
7.
The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone.
Curr Top Med Chem
; 22(5): 366-394, 2022 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35105288
8.
Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation.
RSC Med Chem
; 13(5): 568-584, 2022 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35694691
9.
The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure.
Eur J Med Chem
; 212: 113123, 2021 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33412421
10.
Regioselective microwave synthesis and derivatization of 1,5-diaryl-3-amino-1,2,4-triazoles and a study of their cholinesterase inhibition properties.
RSC Adv
; 9(35): 20356-20369, 2019 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35514684
11.
Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Years.
Curr Top Med Chem
; 18(2): 124-148, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29595110
12.
Vasodilator and antihypertensive effects of a novel N-acylhydrazone derivative mediated by the inhibition of L-type Ca²âº channels.
Fundam Clin Pharmacol
; 28(1): 29-41, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22958093
13.
N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle.
Life Sci
; 94(1): 30-6, 2014 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24269214
14.
A novel Ca2+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension.
Eur J Pharmacol
; 702(1-3): 316-22, 2013 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23399770
15.
Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor.
Eur J Med Chem
; 55: 49-57, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22857782