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1.
Sex Abuse ; : 10790632241268472, 2024 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-39083666

RESUMO

Understanding the difference between the proportion of sexual offenses that are officially detected versus the total number of sexual crimes that occur has been of interest to decision makers for some time. Previous studies have not considered possible racial differences. More aggressive responses by police and the criminal justice system as well as cultural differences in victim type/reporting rates may result in differences between detection rates of Black versus White men. In the current study (N = 190), we examined the difference between Black (n = 51) and White (n = 139) men committed to a forensic hospital as a Sexually Violent Person on factors that could impact the detected rate. Overall, we found that White men had significantly more total victims, undetected victims, undetected and detected child victims, total male victims, undetected male victims, undetected acquaintance victims, and total (detected and undetected) acquaintance victims than Black men. Black men had significantly more detected adult victims, but this difference did not remain when accounting for undetected victims. We explore reasons for these differences as well as provide recommendations for practice.

2.
J Acoust Soc Am ; 153(5): 3075, 2023 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-37222723

RESUMO

As the ecological importance of gelatinous organisms becomes increasingly appreciated, so has the need for improved knowledge of their abundance and distribution. Acoustic backscattering measurements are routine for fisheries assessments but are not yet widely used to survey populations of gelatinous zooplankton. The use of acoustic backscattering techniques to understand the distribution and abundance of organisms requires an understanding of their target strength (TS). This study presents a framework for a sound scattering model for jellyfish based on the Distorted Wave Born Approximation that incorporates size, shape, and material properties of individual organisms. This model, with a full three-dimensional shape rendition, is applied to a common species of scyphomedusa (Chrysaora chesapeakei) and verified experimentally with broadband (52-90 and 93-161 kHz) laboratory TS measurements of live individuals. Cyclical changes in the organism's shape due to swimming kinematics were examined, as well as averages over swimming position and comparisons with scattering from simpler shapes. The model predicts overall backscattering levels and broad spectral behavior within <2 dB. Measured TS exhibits greater variability than is predicted by scaling the size of the organism in the scattering model, showing that density and sound speed vary among individuals.


Assuntos
Acústica , Pesqueiros , Humanos , Gelatina , Som , Natação
3.
Sex Abuse ; 35(5): 624-648, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36377528

RESUMO

Undetected sexual offending creates challenges for risk assessment since estimated sexual recidivism rates are based on documented charges or convictions. Courts and other stakeholders may be primarily interested in the true risk for sexual reoffense and not simply risk for detected sexual offenses. Attempts to study and quantify the rate of undetected sexual offending have resulted in a wide variety of estimates. In this study, we explore whether sanctions imposed for detected sexual offenses increase the detection rate of subsequent offenses, and thereby suppress undetected sexual offending in an exceptionally high-risk sample who were ultimately committed as Sexually Violent Persons. Results indicate the detection rate of sexual offenses increased following an initial sanction, subsequently decreasing the proportion of undetected to detected offending. This effect only occurred after the first sanction. Overall, the sample had a high detection rate and spent little time in the community before subsequent arrests. These results differ from other reports that high rates of sexual offenses go undetected.


Assuntos
Reincidência , Delitos Sexuais , Humanos , Comportamento Sexual , Medição de Risco
4.
Behav Sci Law ; 40(3): 351-364, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35083773

RESUMO

Civilly committed sexually violent persons (SVPs) are a select group of individuals designated as high risk for future sexual violence. Despite risk reduction in older age, SVP programs are seeing aging client populations, with many individuals remaining committed after age 60 (60+). Recent research found a sexual recidivism rate of 7.5% for 60+ individuals released from an SVP civil commitment program. The current paper follows up by examining reasons why individuals remain committed after age 60. It compares SVPs discharged after age 60 to those who are 60+ but remain civilly committed. Results of bivariate analyses reveal older SVPs who remain committed have significantly higher actuarial risk scores and are more likely to be of minority race. Multivariate logistic regression analyses found actuarial risk scores (Static-99R) predicted continued commitment, after controlling for other relevant variables. Barriers to community reintegration and suggestions for multi-disciplinary case management for older SVPs are discussed.


Assuntos
Reincidência , Delitos Sexuais , Humanos , Pessoa de Meia-Idade , Alta do Paciente , Medição de Risco , Fatores de Risco , Comportamento Sexual
5.
Sex Abuse ; 34(4): 483-504, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34088251

RESUMO

Evaluating patient satisfaction in therapeutic settings is consistent with a Risk-Needs-Responsivity (RNR) model. This study provides results from a program improvement initiative in a sexually violent person (SVP) civil commitment facility that queried patients and treatment providers about their satisfaction with therapeutic processes and assessment methods. Overall, patients reported high levels of satisfaction with treatment at the facility, with the highest levels of satisfaction on items about being treated with kindness and respect and staff acting professionally. Providers rated current assessment methods such as the Penile Plethysmography (PPG) assessment, polygraph testing, and neuropsychological testing as most helpful for patients in treatment progress; however, patients rated PPG assessment and polygraph testing as the least helpful of the assessments conducted. Soliciting patient feedback periodically could be important for maintaining treatment engagement and discovering opportunities to enhance patient satisfaction to treatment in a SVP civil commitment setting.


Assuntos
Internação Compulsória de Doente Mental , Delitos Sexuais , Agressão , Humanos , Satisfação Pessoal , Delitos Sexuais/psicologia , Comportamento Sexual
6.
Sex Abuse ; 33(7): 839-866, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33158402

RESUMO

Adverse childhood experiences (ACEs) are increasingly recognized as a public health crisis. Cumulative effects of these experiences lead to a wide range of deleterious physical and psychological outcomes. Prior research has identified higher prevalence rates of ACEs and increased criminal behavior in samples of individuals who have committed sexual offenses. In a sample of civilly committed individuals who have committed sexual offenses (N = 317), we examined the prevalence of ACEs (cumulative scores and the two components of child harm and family dysfunction) and their association with risk for sexual recidivism and adult psychopathology. ACEs were much more prevalent in this sample compared with the general population and to lower risk samples of individuals who had committed sexual offenses. Although ACE scores were unrelated to risk for sexual recidivism, higher ACE scores were associated with increased risk of psychopathology, including anxiety disorders, depressive disorders, substance use disorders, and Antisocial Personality Disorder. ACEs related to family dysfunction were uniquely associated with Alcohol Use Disorder and the presence of a dual diagnosis of a paraphilia and personality disorder. Results suggest that higher risk individuals who commit sexual offenses may have greater need for trauma-informed models of care that recognize the effect of these experiences on their mental health and offense-related behavior.


Assuntos
Experiências Adversas da Infância , Criminosos , Transtornos Parafílicos , Reincidência , Delitos Sexuais , Adulto , Criança , Humanos
7.
J Adolesc ; 72: 83-90, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30875564

RESUMO

INTRODUCTION: Adolescence is a period when impulsive decision making may be especially vulnerable to environmental influences. Impulsive decision making is often assessed using a delay discounting paradigm, which measures the preference for smaller rewards sooner over larger rewards with a delay. Research is needed to clarify the relationship between parents' and adolescents' delay discounting and to identify related environmental processes that might facilitate the intergenerational transmission of delay discounting. The current prospective longitudinal study examined the competing mediating processes of household chaos and harsh parenting in the intergenerational transmission of delay discounting between parents and adolescents. METHODS: Participants included 167 adolescents (mean age = 14.07 years at Time 1; 53% male) and their parents (mean age = 41.98 years at Time 1; 87% female) recruited from the southeast United States. Parents' delay discounting was collected at Time 1, and adolescents' delay discounting was collected both at Time 1 and at Time 3 via a computerized delay discounting task. Parents and adolescents reported household chaos and harsh parenting at Time 2. RESULTS: A parallel mediation model indicated that parents' delay discounting at Time 1 indirectly predicted adolescents' delay discounting Time 3 residualized change scores (regressing Time 3 delay discounting onto baseline delay discounting) through household chaos but not through harsh parenting at Time 2. CONCLUSIONS: These results underline the importance of household chaos in facilitating the intergenerational transmission of delay discounting between parents and adolescents. Furthermore, our findings point to household chaos as a potential environmental target for interrupting intergenerational impulsivity.


Assuntos
Desvalorização pelo Atraso , Características da Família , Comportamento Impulsivo , Poder Familiar/psicologia , Adolescente , Desenvolvimento do Adolescente , Adulto , Feminino , Humanos , Relação entre Gerações , Estudos Longitudinais , Masculino , Estudos Prospectivos
8.
J Youth Adolesc ; 48(1): 43-55, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30178385

RESUMO

Extant literature has demonstrated that self-control is critical for health and adjustment in adolescence. Questions remain regarding whether there are individuals that may be most vulnerable to impaired self-control development and whether aspects of the structural home environment may predict membership in these subgroups, as well as the behavioral consequences of impaired self-control trajectories. The present study utilized growth mixture modeling and data from 1083 individuals (50% female, 82% White) from age 8.5 to 15 years to identify four latent classes of self-control development. Additionally, higher household chaos and lower socioeconomic status at age 8.5 were associated with maladaptive trajectories of self-control at ages 8.5-11.5. In turn, maladaptive self-control trajectories at ages 8.5-11.5 were associated with higher risk taking at age 15. The results highlight the importance of increased structure and support for at-risk youth.


Assuntos
Comportamento do Adolescente/psicologia , Agressão/psicologia , Delinquência Juvenil/psicologia , Assunção de Riscos , Autocontrole , Adolescente , Desenvolvimento do Adolescente , Criança , Características da Família , Feminino , Humanos , Masculino , Classe Social
9.
Dis Colon Rectum ; 61(12): 1386-1392, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30312221

RESUMO

BACKGROUND: Surgeons present patients with complex information at the perioperative appointment. Emotions likely play a role in surgical decision-making, and disgust is an emotion of revulsion at a stimulus that can lead to avoidance. OBJECTIVE: The purpose of this study was to determine the impact of disgust on intention to undergo surgical resection for colorectal cancer and recall of perioperative instructions. DESIGN: This was a cross-sectional observational study conducted online using hypothetical scenarios with nonpatient subjects. SETTINGS: The study was conducted using Amazon's Mechanical Turk. PATIENTS: Survey respondents were living in the United States. MAIN OUTCOME MEASURES: Surgery intention and recall of perioperative instructions were measured. RESULTS: A total of 319 participants met the inclusion criteria. Participants in the experimental condition, who were provided with detailed information and pictures about stoma care, had significantly lower surgery intentions (mean ± SD, 4.60 ± 1.15) compared with the control condition with no stoma prompt (mean ± SD, 5.14 ± 0.91; p = 0.05) and significantly lower recall for preoperative instructions (mean ± SD, 13.75 ± 2.38) compared with the control condition (mean ± SD, 14.36 ± 2.19; p = 0.03). Those within the experimental conditions also reported significantly higher state levels of disgust (mean ± SD, 4.08 ± 1.74) compared with a control condition (mean ± SD, 2.35 ± 1.38; p < 0.001). State-level disgust was found to fully mediate the relationship between condition and recall (b = -0.31) and to partially mediate the effect of condition on surgery intentions (b = 0.17). LIMITATIONS: It is unknown whether these results will replicate with patients and the impact of competing emotions in clinical settings. CONCLUSIONS: Intentions to undergo colorectal surgery and recall of preoperative instructions are diminished in patients who experience disgust when presented with stoma information. Surgeons and care teams must account for this as they perform perioperative counseling to minimize interference with recall of important perioperative information. See Video Abstract at http://links.lww.com/DCR/A776.


Assuntos
Neoplasias Colorretais/psicologia , Neoplasias Colorretais/cirurgia , Asco , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Adulto , Colostomia/psicologia , Estudos Transversais , Tomada de Decisões , Feminino , Humanos , Intenção , Masculino , Rememoração Mental , Pessoa de Meia-Idade , Educação de Pacientes como Assunto , Período Perioperatório , Inquéritos e Questionários , Estados Unidos
10.
Curr Psychiatry Rep ; 20(8): 55, 2018 07 21.
Artigo em Inglês | MEDLINE | ID: mdl-30032365

RESUMO

PURPOSE OF REVIEW: This paper reviews recent research into four different approaches to the assessment of offense-related sexual deviance. RECENT FINDINGS: Two of these approaches, structured rating scales and phallometry, have a sufficient basis in research for clinical use but have undergone significant refinements in recent years. One approach, the use of cognitive tasks to indirectly assess sexual deviance, is approaching the point where it has a sound research basis for clinical use though too many promising tasks have yet to make the transition from laboratory to clinical practice. This approach has however begun to map the earlier stages of sexual response including preconscious processes. The final approach, assessment through neuroimaging, is at the earliest stage of development with research findings having yet to reach sufficient stability for clinical application. Existing assessment technologies, despite their limitations, allow professionals to assess offense-related sexual deviance. New approaches, currently being developed, potentially allow a better understanding of underlying processes and, when sufficiently mature, will be more therapeutically useful.


Assuntos
Transtornos Parafílicos/diagnóstico , Humanos , Transtornos Parafílicos/fisiopatologia , Transtornos Parafílicos/psicologia , Delitos Sexuais/psicologia , Comportamento Sexual
11.
Appetite ; 128: 321-332, 2018 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-29902503

RESUMO

The mechanisms that lead to overeating and the consumption of tempting, unhealthy foods have been studied extensively, but the compensatory actions taken afterwards have not. Here we describe the naïve models individuals hold around dietary splurges (single bouts of overeating) and associated weight changes. Across six online experiments, we found that, following a hypothetical dietary splurge, participants did not plan to adequately adjust calorie consumption to account for the additional calories consumed (Studies 1 and 2), and this pattern was worse following hypothetical splurges characterized by a large amount of food consumed in a single bout (Study 3). Participants expected weight changes to happen faster than they do in reality (Study 4) and they expected that weight gained from a dietary splurge would disappear on its own without explicit compensation attempts through diet or exercise (Study 5). Similarly, participants expected that when compensation attempts were made through calorie restriction, the rate of weight loss would be faster following a dietary splurge compared to normal eating (Study 6). This research contributes novel data demonstrating an important mechanism that likely contributes to weight gain and failed weight loss attempts.


Assuntos
Restrição Calórica/psicologia , Dieta/psicologia , Comportamento Alimentar/psicologia , Hiperfagia/psicologia , Aumento de Peso , Adulto , Dieta/métodos , Feminino , Humanos , Hiperfagia/fisiopatologia , Masculino , Fatores de Tempo , Redução de Peso
12.
Subst Use Misuse ; 53(8): 1299-1310, 2018 07 03.
Artigo em Inglês | MEDLINE | ID: mdl-29308966

RESUMO

BACKGROUND: Within the dual systems perspective, high reward sensitivity and low punishment sensitivity in conjunction with deficits in cognitive control may contribute to high levels of risk taking, such as substance use. OBJECTIVE: The current study examined whether the individual components of effortful control (inhibitory control, attentional control, and activation control) serve as regulators and moderate the association between reward or punishment sensitivity and substance use behaviors. METHOD: A total of 1,808 emerging adults from a university setting (Mean age = 19.48; 72% female) completed self-report measures of reward and punishment sensitivity, effortful control, and substance use. RESULTS: Findings indicated significant two-way interactions for punishment sensitivity and inhibitory control for alcohol and marijuana use. The form of these interactions revealed a significant negative association between punishment sensitivity and alcohol and marijuana use at low levels of inhibitory control. No significant interactions emerged for reward sensitivity or other components of effortful control. CONCLUSIONS: The current findings provide preliminary evidence suggesting the dual systems theorized to influence risk taking behavior interact to make joint contributions to health risk behaviors such as substance use in emerging adults.


Assuntos
Consumo de Bebidas Alcoólicas/psicologia , Controle Interno-Externo , Uso da Maconha/psicologia , Punição/psicologia , Recompensa , Temperamento , Adolescente , Adulto , Feminino , Humanos , Masculino , Autoimagem , Adulto Jovem
13.
Child Psychiatry Hum Dev ; 49(4): 523-533, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29147838

RESUMO

Aggression is an important risk factor for various forms of problem behaviors in adolescence, and research has often distinguished between reactive and proactive forms of aggression. The aim of the present study was to compare the psychometric properties (i.e., structural invariance, internal consistency, and criterion validity) of the Reactive-Proactive Aggression Questionnaire (RPQ) between males and females among a mixed-gender school sample of 782 Portuguese youth (M = 15.87 years, SD = 1.72). Confirmatory factor analysis revealed that a two-factor first-order structure obtained the best fit and cross-gender measurement invariance was demonstrated after excluding item 21. The Portuguese version of the RPQ demonstrated generally adequate psychometric properties of internal consistency measured by Cronbach's alpha and omega coefficient, convergent validity, discriminant validity, criterion-related validity, and known-groups validity. Findings are discussed in terms of the use of the RPQ with male and female youths.


Assuntos
Agressão/psicologia , Comportamento Problema/psicologia , Estudantes/psicologia , Adolescente , Análise Fatorial , Feminino , Humanos , Masculino , Psicometria , Reprodutibilidade dos Testes , Instituições Acadêmicas , Inquéritos e Questionários
14.
Eat Disord ; 25(5): 420-435, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28876200

RESUMO

Parent-adolescent relationship quality and affective functioning have been implicated in eating disorder development. This study examined whether maternal and paternal hostility interact to explain adolescents' eating disorder symptoms and whether parental hostility effects are more pronounced among adolescents with high emotional reactivity. A sample of 699 adolescents, ages 11-12 years, reported their parents' hostility and their own eating disorder symptoms, and parents reported adolescents' emotional reactivity. Results from structural equation modeling indicated that for emotionally reactive adolescents, paternal hostility was positively associated with eating disorder symptoms at both high and low levels of maternal hostility. In addition, eating disorder symptoms were amplified when both parents were high in hostility. Findings from this study lend support for the role of emotional reactivity in the link between parent hostility and eating disorder symptoms during adolescence.


Assuntos
Transtornos da Alimentação e da Ingestão de Alimentos/psicologia , Hostilidade , Relações Pais-Filho , Pais/psicologia , Adolescente , Comportamento do Adolescente/psicologia , Imagem Corporal , Criança , Feminino , Humanos , Masculino
15.
Child Psychiatry Hum Dev ; 47(6): 903-917, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-26779640

RESUMO

Emotional intelligence (EI) is the ability to perceive, manage, and reason about emotions and to use this information to guide thinking and behavior adaptively. Youth with callous-unemotional (CU) traits demonstrate a variety of affective deficits, including impairment in recognition of emotion and reduced emotional responsiveness to distress or pain in others. We examined the association between ability EI and CU traits in a sample of incarcerated adolescents (n = 141) using an expert-rater device (Psychopathy Checklist Youth Version (PCL-YV; Manual for the Hare psychopathy checklist: Youth version. Multi-Health Systems, Toronto, 2003) and self-report assessments of CU traits. EI was assessed using the Mayer-Salovey-Caruso Emotional Intelligence Test-Youth Version, Research Version (MSCEIT-YV-R; MSCEIT YV: Mayer-Salovey-Caruso emotional intelligence test: Youth version, research version 1.0. Multi-Health Systems, Toronto, Ontario, 2005). Similar to findings in adult forensic populations, high levels of CU traits in incarcerated adolescents were associated with lower EI, particularly higher order EI skills. Identifying impairment on EI abilities may have important implications for emerging treatment and intervention developments for youth with high levels of CU traits.


Assuntos
Comportamento do Adolescente/psicologia , Transtorno da Personalidade Antissocial , Inteligência Emocional , Delinquência Juvenil , Habilidades Sociais , Adolescente , Transtorno da Personalidade Antissocial/diagnóstico , Transtorno da Personalidade Antissocial/psicologia , Escala de Avaliação Comportamental , Pesquisa Comportamental , Feminino , Humanos , Delinquência Juvenil/legislação & jurisprudência , Delinquência Juvenil/psicologia , Masculino , Testes de Personalidade , Prisioneiros/psicologia , Autorrelato , Autocontrole/psicologia
16.
J Youth Adolesc ; 44(9): 1674-87, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26202153

RESUMO

Parent-adolescent relationship quality and delay discounting may play important roles in adolescents' sexual decision making processes, and levels of self-control during adolescence could act as a buffer within these factors. This longitudinal study included 219 adolescent (55 % male; mean age = 12.66 years at Wave 1; mean age = 15.10 years at Wave 2) and primary caregiver dyads. Structural equation modeling (SEM) was utilized to determine whether delay discounting mediated the association between parent-adolescent relationship quality and adolescents' risky sexual behavior and how this mediated association may differ between those with high versus low self-control. The results revealed parent-adolescent relationship quality plays a role in the development of risky sexual behavior indirectly through levels of delay discounting, but only for adolescents with low self-control. These findings could inform sex education policies and health prevention programs that address adolescent risky sexual behavior.


Assuntos
Comportamento do Adolescente/psicologia , Relações Pais-Filho , Poder Familiar/psicologia , Assunção de Riscos , Autoimagem , Comportamento Sexual/psicologia , Adolescente , Fatores Etários , Feminino , Humanos , Estudos Longitudinais , Masculino , Fatores de Risco
17.
J Child Psychol Psychiatry ; 55(6): 532-48, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24117854

RESUMO

Recent research has suggested that the presence of significant levels of callous-unemotional (CU) traits designates a clinically important and etiologically distinct subgroup of children and adolescents with serious conduct problems. Based on this research, CU traits have been included in the most recent revision of the Diagnostic and Statistical Manual of Mental Disorders-5th Edition (DSM-5; American Psychiatric Association, 2013)--as a specifier for the diagnosis of conduct disorder. In this review, we attempt to understand CU traits within a developmental psychopathological framework. Specifically, we summarize research on the normal development of the prosocial emotions of empathy and guilt (i.e., conscience) and we illustrate how the development of CU traits can be viewed as the normal development of conscience gone awry. Furthermore, we review research on the stability of CU traits across different developmental periods and highlight factors that can influence this stability. Finally, we highlight the implications of this developmental psychopathological framework for future etiological research, for assessment and diagnostic classification, and for treatment of children with serious conduct problems.


Assuntos
Comportamento do Adolescente/psicologia , Comportamento Infantil/psicologia , Transtorno da Conduta/psicologia , Psicologia do Adolescente/métodos , Psicologia da Criança/métodos , Projetos de Pesquisa , Adolescente , Criança , Emoções , Empatia , Culpa , Humanos , Psicopatologia
18.
J Clin Child Adolesc Psychol ; 43(1): 36-42, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-23879532

RESUMO

In forensic samples of adults and adolescents, there is evidence to suggest that there may be distinct variants of psychopathy marked by the presence/absence of significant levels of anxiety. Callous-unemotional (CU) traits can be used to characterize children who share behavioural and neurocognitive features with adult psychopaths. The aims of this paper are to (a) investigate the genetic and environmental influences on CU traits with/without anxiety and (b) explore differences in terms of concurrent and early parenting and adjustment. Discrete groups were formed on the basis of scores in the top 10% of the sample on CU and anxiety scales at age 7. Estimates of group heritability were calculated using a Defries-Fulker (DF) extremes regression model. Follow back analyses of early parenting and adjustment were conducted using multivariate analyses of covariance. There was high group heritability for CU traits with/without anxiety. Children with both high CU and anxiety showed greater levels of adjustment problems than those with CU only at age 7. The two groups did not differ in parenting characteristics. In this general population sample, evidence did not support differences in etiology for the two groups high on CU traits differing in level of anxiety.


Assuntos
Transtorno da Personalidade Antissocial/psicologia , Ansiedade/psicologia , Emoções , Transtorno da Personalidade Antissocial/genética , Criança , Feminino , Interação Gene-Ambiente , Humanos , Masculino , Análise Multivariada , Poder Familiar/psicologia , Ajustamento Social
19.
Nat Commun ; 15(1): 6162, 2024 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-39039076

RESUMO

Senescent cells within tumors and their stroma exert complex pro- and anti-tumorigenic functions. However, the identities and traits of these cells, and the potential for improving cancer therapy through their targeting, remain poorly characterized. Here, we identify a senescent subset within previously-defined cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinomas (PDAC) and in premalignant lesions in mice and humans. Senescent CAFs isolated from mouse and humans expressed elevated levels of immune-regulatory genes. Depletion of senescent CAFs, either genetically or using the Bcl-2 inhibitor ABT-199 (venetoclax), increased the proportion of activated CD8+ T cells in mouse pancreatic carcinomas, whereas induction of CAF senescence had the opposite effect. Combining ABT-199 with an immune checkpoint therapy regimen significantly reduced mouse tumor burden. These results indicate that senescent CAFs in PDAC stroma limit the numbers of activated cytotoxic CD8+ T cells, and suggest that their targeted elimination through senolytic treatment may enhance immunotherapy.


Assuntos
Linfócitos T CD8-Positivos , Fibroblastos Associados a Câncer , Carcinoma Ductal Pancreático , Senescência Celular , Imunoterapia , Neoplasias Pancreáticas , Sulfonamidas , Animais , Fibroblastos Associados a Câncer/imunologia , Fibroblastos Associados a Câncer/metabolismo , Fibroblastos Associados a Câncer/patologia , Neoplasias Pancreáticas/imunologia , Neoplasias Pancreáticas/terapia , Neoplasias Pancreáticas/patologia , Neoplasias Pancreáticas/genética , Linfócitos T CD8-Positivos/imunologia , Camundongos , Humanos , Carcinoma Ductal Pancreático/imunologia , Carcinoma Ductal Pancreático/terapia , Carcinoma Ductal Pancreático/patologia , Carcinoma Ductal Pancreático/genética , Senescência Celular/imunologia , Imunoterapia/métodos , Sulfonamidas/farmacologia , Sulfonamidas/uso terapêutico , Camundongos Endogâmicos C57BL , Linhagem Celular Tumoral , Ativação Linfocitária/imunologia , Feminino , Inibidores de Checkpoint Imunológico/farmacologia , Inibidores de Checkpoint Imunológico/uso terapêutico , Adenocarcinoma/imunologia , Adenocarcinoma/terapia , Adenocarcinoma/genética , Adenocarcinoma/patologia , Masculino , Compostos Bicíclicos Heterocíclicos com Pontes
20.
Law Hum Behav ; 37(2): 87-97, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22731505

RESUMO

Callous-unemotional (CU) traits (e.g., lack of empathy, deficient guilt/remorse, and shallow affect) are a circumscribed facet of the adult psychopathic personality. Although several studies have found that adult psychopathy is a robust predictor of future criminal offending, research exploring the predictive utility of CU traits and future offending are lacking. Moreover, empirical studies examining the predictive utility of psychopathic features often neglect to account for other well-documented risk factors (e.g., prior offending, delinquent peers, marital status), and thus the incremental predictive utility of CU traits remains uncertain. To address these limitations, the current study examined the unique contribution of CU traits in the prediction of future criminal offending in a large ethnically diverse community sample of young adult males (Mean Age = 25.76, SD = .95). Official criminal record information was collected approximately 3.5 years later using multiple sources. Results indicated that after controlling for several other well-established predictors of future offending, men with elevated CU traits had a greater number of arrests and criminal charges and were more likely to be charged with a serious offense and obstruction of justice. CU traits also predicted future theft for Caucasian men, but not African American men. Overall, the results support the notion that CU traits significantly add to the prediction of future offending, even after controlling for several other risk factors.


Assuntos
Transtorno da Personalidade Antissocial/psicologia , Crime/psicologia , Inventário de Personalidade , Adulto , Crime/estatística & dados numéricos , Empatia , Humanos , Estudos Longitudinais , Masculino , Adulto Jovem
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