Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
1.
Magn Reson Med ; 81(3): 1979-1992, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30393895

RESUMO

PURPOSE: Prostate diffusion-weighted MRI scans can suffer from geometric distortions, signal pileup, and signal dropout attributed to differences in tissue susceptibility values at the interface between the prostate and rectal air. The aim of this work is to present and validate a novel model based reconstruction method that can correct for these distortions. METHODS: In regions of severe signal pileup, standard techniques for distortion correction have difficulty recovering the underlying true signal. Furthermore, because of drifts and inaccuracies in the determination of center frequency, echo planar imaging (EPI) scans can be shifted in the phase-encoding direction. In this work, using a B0 field map and a set of EPI data acquired with blip-up and blip-down phase encoding gradients, we model the distortion correction problem linking the distortion-free image to the acquired raw corrupted k-space data and solve it in a manner analogous to the sensitivity encoding method. Both a quantitative and qualitative assessment of the proposed method is performed in vivo in 10 patients. RESULTS: Without distortion correction, mean Dice similarity scores between a reference T2W and the uncorrected EPI images were 0.64 and 0.60 for b-values of 0 and 500 s/mm2 , respectively. Compared to the Topup (distortion correction method commonly used for neuro imaging), the proposed method achieved Dice scores (0.87 and 0.85 versus 0.82 and 0.80) and better qualitative results in patients where signal pileup was present because of high rectal gas residue. CONCLUSION: Model-based reconstruction can be used for distortion correction in prostate diffusion MRI.


Assuntos
Imagem de Difusão por Ressonância Magnética , Imagem Ecoplanar , Processamento de Imagem Assistida por Computador/métodos , Próstata/diagnóstico por imagem , Neoplasias da Próstata/diagnóstico por imagem , Idoso , Algoritmos , Artefatos , Difusão , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Teóricos
2.
Neuroimage ; 182: 314-328, 2018 11 15.
Artigo em Inglês | MEDLINE | ID: mdl-28774648

RESUMO

Mapping axon diameters within the central and peripheral nervous system could play an important role in our understanding of nerve pathways, and help diagnose and monitor an array of neurological disorders. Numerous diffusion MRI methods have been proposed for imaging axon diameters, most of which use conventional single diffusion encoding (SDE) spin echo sequences. However, a growing number of studies show that oscillating gradient spin echo (OGSE) sequences can provide additional advantages over conventional SDE sequences. Recent theoretical results suggest that this is especially the case in realistic scenarios, such as when fibres have unknown or dispersed orientation. In the present study, we adopt the ActiveAx approach to experimentally investigate the extent of these advantages by comparing the performances of SDE and trapezoidal OGSE in viable nerve tissue. We optimise SDE and OGSE ActiveAx protocols for a rat peripheral nerve tissue and test their performance using Monte Carlo simulations and a 800 mT/m gradient strength pre-clinical imaging experiment. The imaging experiment uses excised sciatic nerve from a rat's leg placed in a MRI compatible viable isolated tissue (VIT) maintenance chamber, which keeps the tissue in a viable physiological state that preserves the structural complexity of the nerve and enables lengthy scan times. We compare model estimates to histology, which we perform on the nerve post scanning. Optimisation produces a three-shell SDE and OGSE ActiveAx protocol, with the OGSE protocol consisting of one SDE sequence and two low-frequency oscillating gradient waveform sequences. Both simulation and imaging results show that the OGSE ActiveAx estimates of the axon diameter index have a higher accuracy and a higher precision compared to those from SDE. Histology estimates of the axon diameter index in our nerve tissue samples are 4-5.8 µm and these are excellently matched with the OGSE estimates 4.2-6.5 µm, while SDE overestimates at 5.2-8 µm for the same sample. We found OGSE estimates to be more precise with on average a 0.5 µm standard deviation compared to the SDE estimates which have a 2 µm standard deviation. When testing the robustness of the estimates when the number of the diffusion gradient directions reduces, we found that both OGSE and SDE estimates are affected, however OGSE is more robust to these changes than the SDE. Overall, these results suggest, quantitatively and in in vivo conditions, that low-frequency OGSE sequences may provide improved accuracy of axon diameter mapping compared to standard SDE sequences.


Assuntos
Axônios , Imageamento por Ressonância Magnética/métodos , Neuroimagem/métodos , Nervo Isquiático/diagnóstico por imagem , Animais , Simulação por Computador , Imagem de Difusão por Ressonância Magnética/métodos , Imagem de Difusão por Ressonância Magnética/normas , Imageamento por Ressonância Magnética/normas , Método de Monte Carlo , Neuroimagem/normas , Ratos , Ratos Sprague-Dawley , Sensibilidade e Especificidade
3.
Phys Med Biol ; 65(21): 21NT01, 2020 11 05.
Artigo em Inglês | MEDLINE | ID: mdl-32992306

RESUMO

Multi-parametric MRI is increasingly used for prostate cancer detection. Improving information from current sequences, such as T2-weighted and diffusion-weighted (DW) imaging, and additional sequences, such as magnetic resonance spectroscopy (MRS) and chemical exchange saturation transfer (CEST), may enhance the performance of multi-parametric MRI. The majority of these techniques are sensitive to B0-field variations and may result in image distortions including signal pile-up and stretching (echo planar imaging (EPI) based DW-MRI) or unwanted shifts in the frequency spectrum (CEST and MRS). Our aim is to temporally and spatially characterize B0-field changes in the prostate. Ten male patients are imaged using dual-echo gradient echo sequences with varying repetitions on a 3 T scanner to evaluate the temporal B0-field changes within the prostate. A phantom is also imaged to consider no physiological motion. The spatial B0-field variations in the prostate are reported as B0-field values (Hz), their spatial gradients (Hz/mm) and the resultant distortions in EPI based DW-MRI images (b-value = 0 s/mm2 and two oppositely phase encoded directions). Over a period of minutes, temporal changes in B0-field values were ≤19 Hz for minimal bowel motion and ≥30 Hz for large motion. Spatially across the prostate, the B0-field values had an interquartile range of ≤18 Hz (minimal motion) and ≤44 Hz (large motion). The B0-field gradients were between -2 and 5 Hz/mm (minimal motion) and 2 and 12 Hz/mm (large motion). Overall, B0-field variations can affect DW, MRS and CEST imaging of the prostate.


Assuntos
Imageamento por Ressonância Magnética/métodos , Próstata/diagnóstico por imagem , Humanos , Processamento de Imagem Assistida por Computador , Masculino , Movimento , Imagens de Fantasmas
4.
Magn Reson Imaging ; 65: 90-99, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31655138

RESUMO

In prostate Diffusion Weighted MRI, differences in susceptibility values exist at the interface between the prostate and rectal-air. This can result in off-resonance magnetic field leading to geometric distortions including signal stretching and signal pile-up in the reconstructed images. Using a set of EPI data acquired with blip-up and blip-down phase encoding gradient directions, model based reconstruction has recently been proposed that can correct these distortions by using a B0 field estimated from a separate B0 scan. However, change in the size of the rectal air region across time can occur that can result in a mismatch of the B0 field to the EPI scan. Also, the measured B0 field itself can be erroneous in regions of low Signal to Noise ratio around the prostate rectal air interface. In this work, using a set of single shot EPI data acquired with blip-up and blip-down phase encoding gradient directions, a novel joint model based reconstruction is proposed that can account for changes in the off resonance effects between the B0 and EPI scans. For ten prostate patients, using a measured B0 field as an initial B0 estimate, on a 5-point scale (1-5) image quality scores evaluated by an experienced radiologist, the proposed framework achieved scores of 3.50 ±â€¯0.85 and 3.40 ±â€¯0.51 for b-values of 0 and 500 s/mm2, respectively compared to 3.40 ±â€¯0.70 and 3.30 ±â€¯0.67 for model based reconstruction. The proposed framework is also capable of estimating a distortion corrected EPI image even without an initial B0 field estimate in situations where a separate B0 scan cannot be obtained due to time constraint.


Assuntos
Imagem de Difusão por Ressonância Magnética , Imagem Ecoplanar , Processamento de Imagem Assistida por Computador/métodos , Próstata/diagnóstico por imagem , Idoso , Idoso de 80 Anos ou mais , Ar , Algoritmos , Artefatos , Análise de Fourier , Humanos , Masculino , Pessoa de Meia-Idade , Vibração
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA