Detalhe da pesquisa
1.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2·4 mg for weight management: a randomised, controlled, phase 1b trial.
Lancet
; 397(10286): 1736-1748, 2021 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33894838
2.
Anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a healthy volunteer study.
Allergy
; 77(8): 2393-2403, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35184297
3.
A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Oral Doses of V-7404 in Healthy Adult Volunteers.
Antimicrob Agents Chemother
; 65(10): e0102921, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34370575
4.
Thorough QT Study To Evaluate the Effect of Zoliflodacin, a Novel Therapeutic for Gonorrhea, on Cardiac Repolarization in Healthy Adults.
Antimicrob Agents Chemother
; 65(12): e0129221, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34606332
5.
A randomized, double-blind, placebo-controlled, single and multiple ascending dose Phase 1 study to determine the safety, pharmacokinetics and food and faecal microbiome effects of ibezapolstat administered orally to healthy subjects.
J Antimicrob Chemother
; 75(12): 3635-3643, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32892222
6.
A First-in-Human Study To Assess the Safety and Pharmacokinetics of LYS228, a Novel Intravenous Monobactam Antibiotic in Healthy Volunteers.
Antimicrob Agents Chemother
; 63(7)2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31061156
7.
Effects of CYP3A inhibitors on the pharmacokinetics of quizartinib, a potent and selective FLT3 inhibitor, and its active metabolite.
Br J Clin Pharmacol
; 85(9): 2108-2117, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31173645
8.
Safety, Tolerability, and Pharmacokinetics of MEDI8897, the Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody with an Extended Half-Life, in Healthy Adults.
Antimicrob Agents Chemother
; 61(3)2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27956428
9.
A phase 1 study to evaluate the safety and pharmacokinetics of MEDI8852, an anti-influenza A monoclonal antibody, in healthy adult volunteers.
Biologicals
; 50: 81-86, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28844541
10.
An open-label study in healthy men to evaluate the risk of seminal fluid transmission of denosumab to pregnant partners.
Br J Clin Pharmacol
; 81(2): 362-9, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26447647
11.
Results from three phase 1 trials of NNC9204-1177, a glucagon/GLP-1 receptor co-agonist: Effects on weight loss and safety in adults with overweight or obesity.
Mol Metab
; 78: 101801, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37690519
12.
AV-101, a novel inhaled dry-powder formulation of imatinib, in healthy adult participants: a phase 1 single and multiple ascending dose study.
ERJ Open Res
; 9(2)2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36923571
13.
Pharmacokinetics and Safety of Vibegron 75 mg Administered as an Intact or Crushed Tablet in Healthy Adults.
Clin Pharmacol Drug Dev
; 11(11): 1349-1355, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36104302
14.
Transition from Syringe to Autoinjector Based on Bridging Pharmacokinetics and Pharmacodynamics of the P2Y12 Receptor Antagonist Selatogrel in Healthy Subjects.
Clin Pharmacokinet
; 61(5): 687-695, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34961905
15.
Effect of Food on the Pharmacokinetics of Quizartinib.
Clin Pharmacol Drug Dev
; 9(2): 277-286, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31916418
16.
Polyvalent Human Immune Globulin: A Prospective, Open-Label Study Assessing Anti-Hepatitis A Virus (HAV) Antibody Levels, Pharmacokinetics, and Safety in HAV-Seronegative Healthy Subjects.
Adv Ther
; 37(5): 2373-2389, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32301062
17.
Persistence of Immune Responses Through 36 Months in Healthy Adults After Vaccination With a Novel Staphylococcus aureus 4-Antigen Vaccine (SA4Ag).
Open Forum Infect Dis
; 7(1): ofz532, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31993453
18.
A Phase I, Randomized, Crossover, Open-label Study of the Pharmacokinetics of Solriamfetol (JZP-110) in Healthy Adult Subjects With and Without Food.
Clin Ther
; 41(2): 196-204, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30598342
19.
Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects.
Drug Des Devel Ther
; 13: 949-964, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962677
20.
Pharmacokinetics, Pharmacodynamics, and Tolerability of Concomitant Multiple Dose Administration of Verinurad (RDEA3170) and Allopurinol in Adult Male Subjects With Gout.
J Clin Pharmacol
; 58(9): 1214-1222, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29733447