Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 54
Filtrar
1.
Acta Orthop Belg ; 84(3): 257-261, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30840566

RESUMO

As it is mentioned in the literature, rates of complications and revision are higher in the obese compared to non-obese patients, although obesity does not a contraindication for unicompartmental knee arthroplasty and successful outcomes are achieved. However, there is not any study in the literature comparing the outcomes of fixed and mobile unicompartmental prostheses which are applied in the obese patients. Objective of this study was to compare outcomes of our obese patients who we applied fixed or mobile unicompartmental arthroplasty and followed up for 8 years and over. Of 293 patients in whom we performed unicompartmental knee prosthesis due to medial gonarthrosis between 2003 and 2014, 239 patients who were regularly followed-up at least for 18 months were included in this study. Total 248 knees with 193 (77.8%) fixed including bilateral prosthesis in 9 patients and 55 (22.2%) mobile prostheses were retrospectively assessed. The study included 57 patients having BMI >30 kg/ m2 who were regularly followed-up. In the final controls; mean flexion was found as 107° (100-128°)(p < 0.05), mean extension as 3° (0-5°) and mean tibio femoral angle as 4° (1-5°) (p < 0.05) valgus. Postoperative mean WOMAC value was found as 91.23 ± 3.02 (92-96) (p < 0.05) and mean KSS score as 88.3 ± 3.94 (85-100) (p < 0.05). In the final controls, respective knee flexions were seen to be 105° (100-125°) and 108°(105-128°) in the fixed and mobile insert subgroups (p > 0.05). Unicompartmental knee prosthesis is a good treatment option which can be applied also in obese patients and has high survival rates. No significant difference was found between the prostheses with fixed and mobile insert in terms of function and knee scores. However, fixed unicompartmental prosthesis should primarily be preferred in obese patients because of the challenging surgical technique, difficult learning curve and insert dislocation that we encounter with mobile prostheses.


Assuntos
Artroplastia do Joelho/instrumentação , Prótese do Joelho , Obesidade/complicações , Osteoartrite do Joelho/cirurgia , Idoso , Artroplastia do Joelho/métodos , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Joelho/complicações , Amplitude de Movimento Articular , Estudos Retrospectivos , Resultado do Tratamento
2.
Acta Orthop Belg ; 83(4): 679-683, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30423678

RESUMO

As it is mentioned in the literature, rates of complications and revision are higher in the obese compared to non-obese patients, although obesity does not a contraindication for unicompartmental knee arthroplasty and successful outcomes are achieved. However, there is not any study in the literature comparing the outcomes of fixed and mobile unicompartmental prostheses which are applied in the obese patients. Objective of this study was to compare outcomes of our obese patients who we applied fixed or mobile unicompartmental arthroplasty and followed up for 8 years and over. Of 293 patients in whom we performed unicompartmental knee prosthesis due to medial gonarthrosis between 2003 and 2014, 239 patients who were regularly followed-up at least for 18 months were included in this study. Total 248 knees with 193 (77.8%) fixed including bilateral prosthesis in 9 patients and 55 (22.2%) mobile prostheses were retrospectively assessed. The study included 57 patients having BMI >30 kg/ m2 who were regularly followed-up. In the final controls; mean flexion was found as 107° (100-128°)(p<0.05), mean extension as 3° (0-5°) and mean tibio femoral angle as 4° (1-5°) (p<0.05) valgus. Postoperative mean WOMAC value was found as 91.23 ± 3.02 (92-96) (p<0.05) and mean KSS score as 88.3 ± 3.94 (85-100) (p<0.05). In the final controls, respective knee flexions were seen to be 105° (100- 125°) and 108°(105-128°) in the fixed and mobile insert subgroups (p>0.05). Unicompartmental knee prosthesis is a good treatment option which can be applied also in obese patients and has high survival rates. No significant difference was found between the prostheses with fixed and mobile insert in terms of function and knee scores. However, fixed unicompartmental prosthesis should primarily be preferred in obese patients because of the challenging surgical technique, difficult learning curve and insert dislocation that we encounter with mobile prostheses.


Assuntos
Artroplastia do Joelho/instrumentação , Articulação do Joelho/fisiopatologia , Prótese do Joelho , Obesidade/complicações , Idoso , Artroplastia do Joelho/efeitos adversos , Índice de Massa Corporal , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Desenho de Prótese , Amplitude de Movimento Articular , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento
3.
Eur J Orthop Surg Traumatol ; 27(1): 133-139, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27659171

RESUMO

PURPOSE: Anterior knee pain (AKP) is one of the most common complications after tibia intramedullary surgery. We evaluated changes in patellar tendon length after tibia intramedullary nailing surgery using a transtendinous approach and assessed the importance of nail position in relation to the anterior tibial cortex and joint line. METHODS: Two surgeons blinded to patients' pain status measured both the knee Insall-Salvati and Caton-Deschamps indexes on 30° flexion lateral knee X-rays of 33 patients. Superior nail prominence (the distance from the proximal tip of the nail to the tibial plateau) and anterior nail prominence (the distance from the anterior tip of the nail to the anterior tibial cortex) were measured on the CT. RESULTS: Clinical assessment showed that 10 patients (30 %) had AKP at the last follow-up. HSS and Lysholm scores and the incidence of AKP were similar between patients whose IM nails were removed and those who still had them. HSS score, Insall-Salvati, and Caton-Deschamps indexes were significantly lower in the operated extremity than in the healthy limb at last follow-up. No association was demonstrated between AKP and nail position in relation to the anterior tibial cortex or tibial plateau. CONCLUSIONS: According to our study, although the patellar tendon shortened significantly on the affected side compared with the contralateral side, these measurements did not correlate with the presence or absence of pain. AKP and functional knee scores after tibia IM nailing using a transtendinous approach were not associated with nail position in relation to the anterior tibial cortex or tibial plateau. LEVEL OF EVIDENCE: Level 3 (Case control study).


Assuntos
Mau Alinhamento Ósseo/etiologia , Pinos Ortopédicos/efeitos adversos , Fíbula/cirurgia , Fixação Intramedular de Fraturas/efeitos adversos , Dor Pós-Operatória/etiologia , Fraturas da Tíbia/cirurgia , Adulto , Artralgia/etiologia , Artralgia/patologia , Feminino , Fíbula/lesões , Fraturas Ósseas/patologia , Fraturas Ósseas/cirurgia , Humanos , Articulação do Joelho , Masculino , Pessoa de Meia-Idade , Ligamento Patelar/patologia , Tíbia/cirurgia , Fraturas da Tíbia/patologia , Adulto Jovem
4.
J Hand Surg Am ; 41(3): 374-80, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26787412

RESUMO

PURPOSE: To evaluate with ultrasound the thickness of the flexor pollicis longus (FPL) tendon and its relationship to the volar locking plate after the fixation of distal radius fractures. METHODS: We evaluated 27 type C2 and C3 distal radius fractures with ultrasound to evaluate damage to the FPL tendon after volar plate fixation. The thickness of the FPL tendon and its distance to the volar plate in the involved wrists and to the volar rim in the contralateral uninjured wrist were measured on sonograms taken 12 months postoperatively. Measurements of the involved wrists were compared with those of the intact wrists. RESULTS: The mean plate-tendon distance in the involved wrist was considerably shorter than the mean volar rim-tendon distance in the intact wrist, and the FPL tendon was considerably thicker in the involved wrist than in the intact wrist. CONCLUSIONS: In distal radial fractures treated with volar locking plates, increases in the thickness of the FPL tendon and a consequent decrease in the distance between the tendon and the plate can be determined with ultrasonography. This finding is a warning that asymptomatic tenosynovitis may eventually cause tendon ruptures. TYPE OF STUDY/LEVEL OF EVIDENCE: Diagnostic IV.


Assuntos
Placas Ósseas , Complicações Pós-Operatórias/diagnóstico por imagem , Fraturas do Rádio/cirurgia , Tenossinovite/diagnóstico por imagem , Articulação do Punho/diagnóstico por imagem , Adulto , Idoso , Feminino , Fixação Interna de Fraturas , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
5.
Arch Orthop Trauma Surg ; 136(10): 1417-23, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27402211

RESUMO

OBJECTIVE: Repair of the neglected achilles tendon ruptures can be challenging due to retraction of tendon stumps. Different repair and augmentation techniques were described. This study aims to investigate long-term results of neglected achilles tendon rupture repair with gastrocnemius flaps. PATIENTS AND METHODS: Between 1995 and 2005, 21 neglected achilles tendon rupture reconstructions were performed with using gastrocnemius fascial flaps. Mean age was 32.1 years. Mean period between rupture and operation was 8.4 weeks. Ankle range of motion, calf circumference, heel raise test, Visual Analog Scale (VAS), American Orthopedic Foot and Ankle Society (AOFAS) hindfoot and Foot and Ankle Disability Index (FADI) scores were checked. RESULTS: The average gap length was 6.4 cm. Mean follow-up was 145.3 months. Median dorsiflexion/plantar flexion values for operated and uneffected sides were 18°/30° and 19°/30°, respectively. The mean values for AOFAS and FADI scores were 98.5 points and 98.9 %, respectively. VAS score was 0 point for all patients. With the numbers available, no significant difference could be detected in terms of ankle range of motion, calf circumference measures and dynamometric analysis. Mean time for return to daily activities was 11.1 (8-16) weeks after surgery. Prerupture activity level was achieved 14.1 months postoperatively. All patients were able to perform heel raise test. CONCLUSION: Repair of neglected achilles tendon ruptures with gastrocnemius flaps has satisfactory long-term results.


Assuntos
Tendão do Calcâneo/lesões , Músculo Esquelético/cirurgia , Procedimentos Ortopédicos/métodos , Procedimentos de Cirurgia Plástica/métodos , Ruptura/cirurgia , Retalhos Cirúrgicos , Traumatismos dos Tendões/cirurgia , Tendão do Calcâneo/cirurgia , Adolescente , Adulto , Animais , Bovinos , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
6.
Arch Orthop Trauma Surg ; 136(7): 929-34, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27155881

RESUMO

OBJECTIVE: This study compares reducing radiation and operation time between single and double C-arm fluoroscopy in the treatment of intertrochanteric femur fractures with intramedullary nails. PATIENTS AND METHODS: Forty four patients participated in the study. Patients were divided into two groups as single (23 patients) and double fluoroscope (21 patients). The time of preparation, the duration of the surgery, the total amount of blood loss, and the total duration of radiation exposure were compared, retrospectively. The collo-diaphyseal angle was compared with that of the contralateral hip on postoperative radiographs. Furthermore, the tip-apex distance and the position of the screws in the femoral head were recorded. RESULTS: The mean preparation periods, collo-diaphyseal angles and blood loss did not differ between groups. In the double-fluoroscopy group, the duration of surgery was 15.9 min shorter (p < 0.001), and the radiation time was 25.7 s shorter (p < 0.001). CONCLUSION: The double fluoroscopy technique can significantly reduce surgical and radiation exposure times during surgery.


Assuntos
Fluoroscopia/métodos , Fixação Intramedular de Fraturas/métodos , Fraturas do Quadril/cirurgia , Articulação do Quadril/cirurgia , Idoso , Idoso de 80 Anos ou mais , Pinos Ortopédicos , Feminino , Fêmur/cirurgia , Fixação Intramedular de Fraturas/efeitos adversos , Fraturas do Quadril/diagnóstico por imagem , Articulação do Quadril/diagnóstico por imagem , Humanos , Masculino , Duração da Cirurgia , Período Pós-Operatório , Estudos Retrospectivos , Resultado do Tratamento
7.
Cureus ; 15(1): e34399, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36874739

RESUMO

Ganglion cysts are masses that we encounter frequently in our daily practice, usually in the upper extremity, less frequently in the lower extremities, and rarely cause compression symptoms. We present a case of a massive ganglion cyst of the lower limb causing peroneal nerve compression, managed with excision and proximal tibiofibular joint arthrodesis to prevent recurrence. Examination and radiological imaging of a 45-year-old female patient who was admitted to our clinic showed new-onset weakness in right foot movements and numbness on the dorsum of the foot and lateral cruris, a mass consistent with a ganglion cyst expanding the muscle was detected in the peroneus longus muscle. In the first surgery, the cyst was carefully resected. After three months, the patient came with a repeated mass on the lateral side of the knee. After confirmation of the ganglion cyst with clinical examination and MRI, a second surgery was planned for the patient. In this stage, we performed a proximal tibiofibular arthrodesis for the patient. Her symptoms recovered during the early follow-up period and no recurrence occurred during the two years of the follow-up period. Although the treatment of ganglion cysts seems easy, it can sometimes be challenging. We think that arthrodesis may be a good treatment option in recurrent cases.

8.
J Knee Surg ; 36(5): 562-568, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34875716

RESUMO

We evaluated the effect of using a tourniquet on early-stage pain and 1-year postoperative functional outcomes when patients were divided into two groups according to the pain threshold (PT). Overall, 120 patients who were assessed preoperatively with an algometer were recruited for this prospective, double-blinded, randomized controlled trial. Patients were randomized to undergo total knee arthroplasty (TKA) with a tourniquet (group 1, 60 patients) and without tourniquet (group 2, 60 patients). Primary outcome measures were visual analog scale (VAS) pain scores at 24, 36, and 48 hours postoperatively and functional assessment with Knee Society Score (KSS) test at 1 year postoperatively. No significant differences were observed between groups in terms of gender (49 females and 8 males in group 1 vs. 53 females and 6 males in group 2; p = 0.201) and age (68.9 years in group 1 vs. 68.7 years in group 2; p = 0.811). There was no significant difference between groups in all the VAS and KSS 1 and KSS 2 scores. PT measurements ranged from 2.5 to 11.5 with a mean of 7.69 ± 1.70 and a median of 8. Total 54 patients with a median value of < 8 were defined as the low-PT group, and 62 patients with a median value of ≥ 8 were defined as the high-PT group. When the groups were evaluated according to using the tourniquet, 21 patients were operated on with a tourniquet and 33 patients without it in the low-PT group, while 36 patients were operated on with a tourniquet and 26 patients without it in the high-PT group. There was no significant difference in pain or functional scores between patients when comparing with-tourniquet and without-tourniquet or when comparing the low- and high-PT groups. This showed that the use of a tourniquet during TKA was not associated with either early-stage pain or 1-year postoperative functional outcomes according to algometer evaluation.Level of evidence: Level 1 prospective randomized study.


Assuntos
Artroplastia do Joelho , Masculino , Feminino , Humanos , Idoso , Artroplastia do Joelho/efeitos adversos , Limiar da Dor , Torniquetes/efeitos adversos , Estudos Prospectivos , Dor Pós-Operatória/etiologia , Resultado do Tratamento , Perda Sanguínea Cirúrgica
9.
J Orthop Case Rep ; 13(11): 24-27, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-38025349

RESUMO

Introduction: Monteggia fracture dislocations are relatively common and debilitating traumas in <10 years of age. This is the second case reporting Monteggia type 3 equivalent injury treated by the same way while the first being reported also by our team in 2016. Case Report: A 4-year-old Caucasian male patient was admitted to our clinic by his parents at the day after his fall. A long arm splint was applied with the diagnosis of Monteggia fracture dislocation in another hospital. Conclusion: Bado introduced his classification system for Monteggia fracture dislocations in 1967. This classification system is mainly based on the direction of dislocation of the radial head. If radial head dislocated laterally with an accompanying ulnar fracture it is classified as Bado type 3 while type 4 is the anterior dislocation of the radial head accompanied with both bone forearm fracture. The unusual fracture dislocation pattern in our case is that lateral dislocation of the radial head is accompanied with both bone forearm fracture, which is an example to be named as Monteggia type 3 equivalent lesion. Closed reduction was not successful to reduce radial head. To reduce the radial head, we used an intramedullary Kirschner and a long arm splint was applied to ensure the safety of the reduction. There was no restriction in elbow movements and the result of the operation was successful.

10.
J Orthop Case Rep ; 12(12): 43-49, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37056598

RESUMO

Introduction: Metacarpal bone fractures often lead to significant shortening in the phalanges; it can be caused by variable conditions, ranging from idiopathic, and infective to traumatic causes. There are very rare reports of metacarpals shortening in idiopathic primary hypoparathyroidism cases in the literature. Traumatic metacarpal shortening differs from congenital agenesis [2]. This condition leads to both functional and cosmetic limitations which affect the patient's quality of life. Case Report: A 22-year-old male patient was admitted to our outpatient clinic with a traumatic left-hand fracture that caused a bone defect in the second metacarpal shaft leading to bone loss, shortening and flexion limitation in the second finger of the left hand, and a flexion contracture in the first metacarpophalangeal joint. For the treatment plan, an external fixator was set on the second metacarpal of the left hand for a 23 mm elongation over a period of 58 days, elongation rate was organized as 1 mm/day. After achieving the planned elongation, another operation was planned for the reconstruction of the bone defect that has occurred due to trauma in the second metacarpal bone. An osteotomy was performed for extracting an iliac crest graft and inserting it into the bone defect after debridement of scar tissue. For the first metacarpophalangeal joint, an arthrodesis was performed through the use of plate and screws. Multiple studies have showed a common complication of pin tract infections, which were controlled with oral antibiotics and local wound care [10, 11]. Proper alignment and union were achieved with early, stable fracture fixation of low-velocity gunshot wounds of the metacarpal. With early rehabilitation, treatment was provided without an increase in morbidity. [11]. Conclusion: It is possible to obtain acceptable surgical results when the method of fixation of the defect with autograft is used after lengthening with external fixator in pseudoarthrosis with metacarpal defect.

11.
Cureus ; 14(6): e26444, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35915673

RESUMO

BACKGROUND AND OBJECTIVES: Literature does not show any studies regarding plate placement problems in the coronal plane of patients with volar plating due to distal radius fracture diagnosis. We aimed to investigate the functional and laboratory results of the coronal malposition of the volar locking plate in patients with distal radius fracture treated with internal fixation. METHODS: In this retrospective study, we included patients who had volar plate fixation, were aged between 18 and 80, had no pathological fracture, had a minimum of six months of follow-up, and had the same rehabilitation protocol. We consider the angle subtended on the coronal axis between the distal radius long axis and the distal radius locking plate as coronal malposition. We named the coronal malposition angle the "AYE Angle." Patients with an AYE angle of over 1 degree were evaluated under group 1. Patients with an AYE angle of 0-1 degrees were evaluated under group 2. Radiological parameters were taken from AP-Lateral X-ray views. Superficial University System of Georgia (USG) examinations were applied to detect tendon problems. The DASH and QUICK-DASH scoring systems were used for clinical evaluation. Grip strength was measured with a dynamometer in all patients. All results were compared between the two groups. RESULTS: Thirteen patients were female and 27 patients were male. Nineteen patients who had coronal malposition were added to group 1, while 21 patients who had no coronal malposition were added to group 2. Fifteen patients had normal USG results in group 2, while 18 patients had edema around the flexor pollicis longus (FPL) tendon as a result of USG in group 1. Statistically, a significant difference was detected between the two groups in terms of the amount of tenosynovitis around FPL (p=0.01). A statistically significant relationship was found between USG grading and malposition grading. The study revealed that a higher rate of USG grade 2 was found in patients with malposition grade 2 (90.9%), while a higher rate of USG grade 1 (50%) was observed in patients with malposition grade 1 (p=0.01). A statistically significant difference was not found between Soong grading and USG in terms of the level of tenosynovitis around the FPL tendon. The amount of tenosynovitis detected around the FPL tendon was 62.5% for Soong and grade 0 level, 60.7% for grade 1 level, and 50% for grade 2 level. There was no statistically significant difference between the two groups in the DASH and QUICK-DASH scoring systems (p=0.96). There was no statistically significant difference between the two groups in the grip strength (p=0.52). CONCLUSION: Coronal plate position in the treatment of the distal radius fracture is important to avoid potential flexor tendon problems. The volar plate position should be adjusted properly both in the coronal and sagittal axes.

12.
Adv Orthop ; 2021: 6632211, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33628513

RESUMO

BACKGROUND: To evaluate the clinical and radiological results of closed reduction, distraction using an external fixator, and percutaneous fixation in patients with Bennet and Rolando fractures. METHODS: Patients over 18 years of age, who had isolated fracture at the base of the first metacarpal bone, had no previous functional limitations and pain complaints, were regularly followed up, and had fixation using K-wire combined with an external fixator, were included. Arthrosis was evaluated according to Eaton and Littler classification. Pain intensity was evaluated using the visual analogue scale (VAS) on a 0-10 scale. Furthermore, patients were questioned regarding limitations in their daily activities and hobbies. Pinch and grasp strengths were evaluated. RESULTS: Thirteen of the patients were male and five were female, with a mean age of 31.5 ± 12.5 years. The surgical procedure was performed on the right extremity in 12 patients and left extremity in six patients. Twelve patients were found to have Bennet fractures, whereas six patients had Rolando fractures. The mean follow-up period of the patients was found to be 29.6 ± 5.4 months. The VAS score was rated as 2 in one patient and 1 in one patient. Other patients had a pain VAS score of 0. The mean Quick-DASH score was calculated to be 1.20. No statistical difference was found in pinch strength between the two extremities (p > 0.05). No difference was observed in terms of the range of motion (p > 0.05). CONCLUSION: Fixation using K-wire combined with an external fixator has more benefits than its disadvantages and is superior to other methods in the intra-articular fractures of the first metacarpal bone.

13.
Eur J Pharm Sci ; 161: 105801, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-33691155

RESUMO

Vaginal infections caused by various pathogens such as fungi, viruses and protozoa are frequently seen. Systemic and local treatments can be applied to eliminate these infections. Novel vaginal drug delivery systems can be used to provide local treatment. Vaginal drug delivery systems prevent systemic side effects and can provide long-term drug release in the vaginal area. Nanofibers and nanoparticles have a wide range of applications and can also be preferred as vaginal drug delivery systems. Benzydamine is a non-steroidal anti-inflammatory and antiseptic drug which is used for treatment of vaginal infections. The aim of this study was to compare the nanofiber and gel formulations containing lyophilized benzydamine nanoparticles with nanofiber and gel formulations containing free benzydamine, and to provide prolonged release for protection from the vaginal infections. Ionic gelation method was used for the preparation of benzydamine loaded nanoparticles. To produce benzydamine nanoparticles loaded nanofiber formulations, polyvinylpyrrolidone (PVP) solutions were prepared at 10% concentrations and mixed with nanoparticles. Hydroxypropyl methylcellulose (HPMC) was used as a gelling agent at the concentration of 1% for the vaginal gel formulation. Nanoparticles were characterized in terms of zeta potential, polydispersity index and particle size. Viscosity, surface tension and conductivity values of the polymer solutions were measured for the electrospinning. Mechanical properties, contact angle and drug loading capacity of the fibers were determined. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), transmission electron microscopy (TEM), fourier-transform infrared (FT-IR) spectroscopy, mucoadhesion, ex vivo permeability studies and in vitro release studies were performed for the selected formulations. Ex vivo permeability studies were performed using Franz diffusion cell method. SEM and TEM images showed that fiber diameters increased with loading of nanoparticles. DSC studies showed no interaction between excipients used in the formulation. Tensile strength and elongation at break values of the fibers increased with the loading of nanoparticles, and the contact angle values of the fibers were found to be 0°. Addition of benzydamine nanoparticles to gel and nanofiber formulations increased mucoadhesion compared to free benzydamine loading formulations. Benzydamine nanoparticle loaded gel and nanofiber formulations penetrated slower than that of free benzydamine gel and fiber formulations. The results demonstrated that benzydamine and benzydamine nanoparticle loaded fibers and gels could be a potential drug delivery system for the treatment of vaginal infections. Chitosan nanoparticle loaded nanofiber formulations are offered as an alternative controlled release vaginal formulations for vaginal infections.


Assuntos
Benzidamina , Quitosana , Nanofibras , Nanopartículas , Preparações de Ação Retardada , Feminino , Humanos , Tamanho da Partícula , Espectroscopia de Infravermelho com Transformada de Fourier
14.
Int J Biol Macromol ; 148: 1084-1097, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31917213

RESUMO

In recent years, electrospun fibers have found wide use, especially in pharmaceutical area and biomedical applications, related to the various advantages such as high surface-volume ratio, high solubility and having wide usage areas they have provided. Biocompatible and biodegradable fibers can be obtained by using peptide-protein structures of plant and animal derived along with synthetic polymers. Plant-derived proteins used in nanofiber production can be listed as, zein, soy protein, and gluten and animal derived proteins can be listed as casein, silk fibroin, hemoglobine, bovine serum albumin, elastin, collagen, gelatin, and keratin. Plant and animal proteins and synthetic peptides used in electrospun fiber production were reviewed in detail. In addition, the important physical properties of these materials for the electrospinning process and their use in pharmaceutical and biomedical areas were discussed.


Assuntos
Materiais Biocompatíveis/química , Nanofibras/química , Peptídeos/química , Proteínas/química , Bioengenharia , Fibroínas/química , Proteínas de Plantas/química
15.
Case Rep Orthop ; 2019: 1610430, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31871805

RESUMO

INTRODUCTION: ACTS secondary to amyloidosis is a very rare situation in the literature, and here, we present a unique case of ACTS secondary to amyloidosis. CASE REPORT: A 61-year-old male patient was admitted to our hospital with complaints of numbness in the lateral half of his 1, 2, 3, and 4 fingers of his right hand. These complaints started acutely, and the patient did not have a history of trauma. His clinical examination was suitable for acute carpal tunnel syndrome. DISCUSSION: Carpal tunnel syndrome, as well as acute carpal tunnel syndrome, may occur based on different causes. ACTS is very rare, especially when it is not caused by a trauma. Here, we presented a unique case of ACTS based on amyloidosis. CONCLUSION: It should be kept in mind when ACTS may occur in patients with the diagnosis of amyloidosis.

16.
Int J Surg ; 68: 142-147, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31276834

RESUMO

BACKGROUND: The diagnosis of anterior cruciate ligament tear can be made by physical examination and magnetic resonance imaging (MRI) in the supine position. In cases where the tear is partially evaluated on MRI, the choice of treatment may vary. The purpose of the study was to investigate the efficiency of MRI at maximum knee flexion in the prone position and to compare the images with findings of the ACL detected during surgery. MATERIALS AND METHODS: Sixty-one patients with partial ACL tears with meniscal and cartilage lesions requiring arthroscopic knee surgery were included in the study between 2017 and 2019. MRI of these patients was prescribed at maximum knee flexion in the prone position. Then, an arthroscopic operation was performed on 61 patients and the findings (intact, partial or total tear of ACL) were recorded. The ACL was evaluated as being intact and partial or total tear. The statistical significance of the efficacy of MRI in the supine position with the knee at maximum flexion in the prone position was compared. RESULTS: It was found that, of 61 patients with suspected partial ACL tears, 25 patients had intact ACLs, 22 patients had partial tears and 14 patients had total ACL tears, through the interpretation of MRIs of the prone position by the radiologist. In the arthroscopic surgery of 61 patients, 20 patients had intact ACLs, 27 patients had a partial tear and 14 patients had a total tear. The MRI results with maximum knee flexion in the prone position were more compatible with the findings of the arthroscopic surgery. CONCLUSIONS: It could be considered that MRI with maximum knee flexion in the prone position may also be guiding in the diagnosis and treatment of patients with partial anterior cruciate ligament rupture.


Assuntos
Lesões do Ligamento Cruzado Anterior/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Adolescente , Adulto , Lesões do Ligamento Cruzado Anterior/cirurgia , Artroscopia , Estudos de Casos e Controles , Feminino , Humanos , Articulação do Joelho/cirurgia , Masculino , Decúbito Ventral , Adulto Jovem
17.
Int J Surg ; 56: 250-255, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29960077

RESUMO

INTRODUCTION: To present the effect of the cerclage fixation, which was performed for the purpose of preserving the alignment obtained by open reduction, on the long-term clinical and radiological results of subtrochanteric fractures. MATERIALS AND METHODS: The inclusion criterias were at least 2 years of follow-up, no severe cognitive impairment, and to be able to walk independently prior to fracture. Patients with transverse or short oblique subtrochanteric hip fractures (AO/OTA class 32-A3.1), patients underwent previous femoral or hip operation for the same side and those with segmental fractures, bilateral fractures and pathological fractures were not included in the study. The clinical and radiological results of the patients were evaluated. The clinical evaluations were performed with Palmer and Parker Mobility Score (PPM), Lower Extremity Functional Score (LEFS), visual analogue score (VAS) and return to pre-injury activity status. The elapsed time between the trauma and the surgery date, the duration of surgery the estimated amount of bleeding, and the length of hospital stay of patients were assessed. RESULTS: Thirty-two of the 52 patients were female and 20 were male. The mean age of females was 77.80 ±â€¯9.75 years and the mean age of the males was 79.18 ±â€¯6.50 years. The mean follow-up period of the patients was 62.25 ±â€¯34.68 months. The mean time until the patients' surgery was 6.18 ±â€¯3.32 days. The mean duration of surgery was 52.6 ±â€¯13.8 min. The mean amount of bleeding was 176 ±â€¯90 ml. The mean length of patients' hospital stay was 6.2 ±â€¯3.2 days. The postoperative mean duration of union was found to be 3.8 ±â€¯1.6 months. The mean value of varus/valgus angulation in coronal plane measurements was 0.52°. No complication was observed in any patient during the cerclage application. The mean number of wire was 1.3. LEFS difference was statistically significant. PPM decline was not statistically significant. CONCLUSION: Open reduction and the use of cerclage did not produce a negative effect in terms of fracture union. The generation of medial support by anatomical reduction of the fracture prevents the implant failure and provide a basis for union.


Assuntos
Pinos Ortopédicos , Fios Ortopédicos , Fixação Interna de Fraturas/instrumentação , Fraturas do Quadril/cirurgia , Redução Aberta/instrumentação , Idoso , Idoso de 80 Anos ou mais , Feminino , Fêmur/diagnóstico por imagem , Fêmur/cirurgia , Fixação Interna de Fraturas/métodos , Fraturas do Quadril/diagnóstico por imagem , Fraturas do Quadril/fisiopatologia , Humanos , Tempo de Internação , Extremidade Inferior/fisiopatologia , Masculino , Pessoa de Meia-Idade , Redução Aberta/métodos , Período Pós-Operatório , Radiografia , Resultado do Tratamento , Caminhada
18.
Ulus Travma Acil Cerrahi Derg ; 24(6): 581-586, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30516260

RESUMO

BACKGROUND: The purpose of this study was to determine the comparative effectiveness of the use of single fluoroscopy versus double fluoroscopy during intramedullary nailing in the oblique position for intertrochanteric femur fractures in terms of surgery and radiation time. METHODS: Fifty-two patients (20 men, 32 women; average age: 78.2 years; range: 69-88 years) were included in the study. While double fluoroscopy was used for 25 patients, single fluoroscopy was used for the remaining 27 patients. Data of the preparation time between anesthesia and surgery, surgery time, radiation time, bleeding volume, postoperative collodiaphyseal angle between the fractures and intact parts, and the tip-apex distance (TAD) were compared. RESULTS: The surgery time in the double and single fluoroscopy groups averaged 34.48±8.92 minutes and 50.37±16.63 minutes, respectively (p<0.01). The radiation time was 42.72±16.00 seconds for the double-fluoroscopy group and 68.22±21.53 seconds for the single-fluoroscopy group (p<0.01). The surgical preparation time, bleeding volume, collodiaphyseal angle and TAD distance did not vary significantly between groups (p>0.05). CONCLUSION: The use of double fluoroscopy in the oblique position in the surgical treatment of intertrochanteric femur fractures reduced the surgical time and the anesthesia time for patients, as well as the exposure to radiation, thereby also reducing the risk of complications.


Assuntos
Fixação Intramedular de Fraturas , Fraturas do Quadril , Duração da Cirurgia , Exposição à Radiação/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Pinos Ortopédicos , Feminino , Fêmur/diagnóstico por imagem , Fêmur/cirurgia , Fluoroscopia/métodos , Fluoroscopia/estatística & dados numéricos , Fixação Intramedular de Fraturas/métodos , Fixação Intramedular de Fraturas/estatística & dados numéricos , Fraturas do Quadril/diagnóstico por imagem , Fraturas do Quadril/cirurgia , Humanos , Masculino
19.
Sisli Etfal Hastan Tip Bul ; 52(3): 173-178, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-32595394

RESUMO

OBJECTIVE: The aim of the present study was to present the results of patients with unstable distal radius fracture treated with closed reduction and percutaneous fixation followed by application of the Pennig dynamic wrist fixator to allow early wrist motion. METHODS: Twenty-five patients diagnosed with distal radius fracture and treated with closed reduction and percutaneous fixation followed by application of a dynamic wrist fixator were included in the study. There were 15 (60%) male and 10 (40%) female patients. The mean age of the patients was 47.32 (20-76) years. The mean period between initial trauma and operation was 8.52 (1-23) days. All patients were allowed active shoulder, elbow, and finger exercises immediately after surgery. RESULTS: Radiological evaluation was performed according to the criteria described by Sarmiento and modified by Lidström. Results were excellent in 12 (46.15%), good in 11 (42.30%), and fair in 3 (11.55%) patients. No patient had poor result. Functional scores were assessed according to the Gartland-Werley classification and modified by Sarmiento. Results were excellent in 14 (56%), good in 8 (32%), and moderate in 3 (12%) patients. CONCLUSION: Use of the Pennig dynamic wrist fixator in the treatment of unstable distal radius fractures has advantages, such as ease of use, minimal surgical trauma, allowing early rehabilitation, and early return to daily activities as well as increased anatomical and functional results.

20.
J Orthop Surg Res ; 13(1): 70, 2018 Apr 03.
Artigo em Inglês | MEDLINE | ID: mdl-29615100

RESUMO

BACKGROUND: Complications related to extensor tendons have begun to increase with the use of volar plates in the treatment of distal radius fractures. In this study, we aimed to compare four-plane radiography and ultrasonography in the evaluation of dorsal cortex screw penetration following volar plate fixation. METHODS: We recruited 47 patients (33 males, 14 females, mean age 37.4 years; range 18-58 years). To evaluate dorsal screw penetration in all patients, we performed radiographs at 45° pronation, 45° supination and obtained dorsal tangential graphs at maximum palmar flexion, and a wrist lateral radiograph. Wrist ultrasonography was performed in all patients. RESULTS: Dorsal screw penetration was detected in 12 of the 47 patients undergoing VLP application. While there was > 2 mm screw penetration in seven patients, there was < 2 mm screw penetration in five patients. On four-plane radiographs, screw penetration > 2 mm was detected in seven patients and screw penetration < 2 mm was detected in two patients. On four-plane radiography, dorsal screw penetration was not detected in three out of five patients, who were shown to have < 2 mm screw penetration by ultrasonography. In addition to perioperative four-plane radiographs are also required to detect dorsal cortex penetration in patients undergoing VLP due to distal radius fracture. However, the detection of screw penetrations < 2 mm is more likely with ultrasonography compared to four-plane radiography. CONCLUSION: We recommend that dorsal cortex screw penetration should be evaluated with perioperative ultrasonography. TRIAL REGISTRATION: Research Registry, researchregistry3344 , Registered 10 January 2017.


Assuntos
Parafusos Ósseos/efeitos adversos , Fixação Interna de Fraturas/efeitos adversos , Fraturas do Rádio/cirurgia , Traumatismos do Punho/diagnóstico por imagem , Traumatismos do Punho/cirurgia , Adolescente , Adulto , Placas Ósseas , Feminino , Fixação Interna de Fraturas/instrumentação , Fixação Interna de Fraturas/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Assistência Perioperatória/métodos , Radiografia , Fraturas do Rádio/diagnóstico por imagem , Ultrassonografia , Traumatismos do Punho/etiologia , Articulação do Punho/diagnóstico por imagem , Articulação do Punho/cirurgia , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA