Detalhe da pesquisa
1.
Elucidating Compound Mechanism of Action by Network Perturbation Analysis.
Cell
; 162(2): 441-451, 2015 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26186195
2.
Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies.
Blood
; 129(1): 88-99, 2017 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27784673
3.
Systematic, network-based characterization of therapeutic target inhibitors.
PLoS Comput Biol
; 13(10): e1005599, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29023443
4.
Network-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis.
Nat Commun
; 15(1): 3909, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38724493
5.
Discovering Venom-Derived Drug Candidates Using Differential Gene Expression.
Toxins (Basel)
; 15(7)2023 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37505720
6.
Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis.
bioRxiv
; 2023 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36824919
7.
Validation of a High-Throughput Dicentric Chromosome Assay Using Complex Radiation Exposures.
Radiat Res
; 199(1): 1-16, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35994701
8.
Elucidating Compound Mechanism of Action and Polypharmacology with a Large-scale Perturbational Profile Compendium.
bioRxiv
; 2023 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37873470
9.
Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators.
Cancer Cell
; 41(5): 933-949.e11, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37116491
10.
OncoLoop: A Network-Based Precision Cancer Medicine Framework.
Cancer Discov
; 13(2): 386-409, 2023 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36374194
11.
A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma.
bioRxiv
; 2023 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36865302
12.
A Transcriptome-Based Precision Oncology Platform for Patient-Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies.
Cancer Discov
; 13(6): 1386-1407, 2023 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37061969
13.
A Model for Network-Based Identification and Pharmacological Targeting of Aberrant, Replication-Permissive Transcriptional Programs Induced by Viral Infection.
Res Sq
; 2022 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35132404
14.
A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection.
Commun Biol
; 5(1): 714, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35854100
15.
A community challenge for a pancancer drug mechanism of action inference from perturbational profile data.
Cell Rep Med
; 3(1): 100492, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35106508
16.
Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19.
Nat Commun
; 13(1): 1891, 2022 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35393402
17.
TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas.
Clin Cancer Res
; 27(20): 5669-5680, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34433651
18.
The RABiT-II DCA in the Rhesus Macaque Model.
Radiat Res
; 196(5): 501-509, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33022052
19.
The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies.
Elife
; 92020 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32945258
20.
The Host Cell ViroCheckpoint: Identification and Pharmacologic Targeting of Novel Mechanistic Determinants of Coronavirus-Mediated Hijacked Cell States.
bioRxiv
; 2020 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32511361