Detalhe da pesquisa
1.
Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice.
J Neurosci
; 38(30): 6640-6652, 2018 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29934348
2.
Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease.
J Neurosci
; 35(24): 9173-81, 2015 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085639
3.
The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway.
J Neurosci
; 35(7): 3190-200, 2015 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25698753
4.
Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease.
J Neurosci
; 32(30): 10117-28, 2012 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22836247
5.
Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes.
J Neurosci
; 32(25): 8663-77, 2012 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22723706
6.
The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation.
J Neurosci
; 31(3): 843-50, 2011 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21248107
7.
Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development.
Proc Natl Acad Sci U S A
; 105(44): 17115-20, 2008 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18952847
8.
Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein.
Mol Cell Biol
; 27(16): 5686-98, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17548467
9.
Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function.
J Neurosci
; 28(27): 6983-95, 2008 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-18596172
10.
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Mol Neurodegener
; 13(1): 29, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29859094
11.
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
J Exp Med
; 212(3): 287-95, 2015 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25732305
12.
The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model.
Cancer Chemother Pharmacol
; 71(4): 929-36, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23358645
13.
ApoE-directed therapeutics rapidly clear ß-amyloid and reverse deficits in AD mouse models.
Science
; 335(6075): 1503-6, 2012 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22323736
14.
Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis.
PLoS One
; 4(12): e8283, 2009 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20011539