Detalhe da pesquisa
1.
Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS.
Anal Biochem
; 518: 9-15, 2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27815077
2.
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2069-2073, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284804
3.
Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2063-2068, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284809
4.
PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.
J Lipid Res
; 51(9): 2611-8, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20453200
5.
Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics.
Biochim Biophys Acta
; 1794(6): 961-7, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19236960
6.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 27(1): 32-40.e3, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31653597
7.
Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase.
Bioorg Med Chem Lett
; 19(10): 2804-7, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19359168
8.
Label-Free, LC-MS-Based Assays to Quantitate Small-Molecule Antagonist Binding to the Mammalian BLT1 Receptor.
SLAS Discov
; 22(9): 1131-1141, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28763622
9.
Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of alpha-keto acid-dependent dioxygenases.
J Inorg Biochem
; 100(12): 2108-16, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17070917
10.
Quantitative Measure of Receptor Agonist and Modulator Equi-Response and Equi-Occupancy Selectivity.
Sci Rep
; 6: 25158, 2016 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27116909
11.
Moderate to high throughput in vitro binding kinetics for drug discovery.
Front Biosci (Schol Ed)
; 8(2): 278-97, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27100706
12.
In Vitro Assays for the Discovery of PCSK9 Autoprocessing Inhibitors.
J Biomol Screen
; 21(10): 1034-1041, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27412534
13.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 28(2): 243, 2021 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33607006
14.
Quantitative analysis of receptor allosterism and its implication for drug discovery.
Expert Opin Drug Discov
; 10(7): 763-80, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25927503
15.
Bridging Model-Dependent Receptor Agonism and Allosterism Parameterization.
Trends Pharmacol Sci
; 37(5): 329-331, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26922255
16.
Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes.
J Med Chem
; 52(19): 6142-52, 2009 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19746978
17.
Resveratrol inhibits firefly luciferase.
Biochem Biophys Res Commun
; 351(2): 481-4, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064666
18.
Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes.
Proc Natl Acad Sci U S A
; 103(35): 12966-73, 2006 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16920789
19.
Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: active site contributions to drug inhibition.
Biochem Biophys Res Commun
; 338(1): 206-14, 2005 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16197918
20.
Accumulation of multiple intermediates in the catalytic cycle of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis.
Biochemistry
; 44(19): 7189-99, 2005 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15882057