Pesquisa | Portal de Pesquisa da BVS

1.

Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.

Dillard, Kaylee E; Brown, Maxwell W; Johnson, Nicole V; Xiao, Yibei; Dolan, Adam; Hernandez, Erik; Dahlhauser, Samuel D; Kim, Yoori; Myler, Logan R; Anslyn, Eric V; Ke, Ailong; Finkelstein, Ilya J.

Cell ; 175(4): 934-946.e15, 2018 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-30343903

2.

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System.

Xiao, Yibei; Luo, Min; Hayes, Robert P; Kim, Jonathan; Ng, Sherwin; Ding, Fang; Liao, Maofu; Ke, Ailong.

Cell ; 170(1): 48-60.e11, 2017 Jun 29.

Artigo em Inglês | MEDLINE | ID: mdl-28666122

3.

Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips.

Jung, Cheulhee; Hawkins, John A; Jones, Stephen K; Xiao, Yibei; Rybarski, James R; Dillard, Kaylee E; Hussmann, Jeffrey; Saifuddin, Fatema A; Savran, Cagri A; Ellington, Andrew D; Ke, Ailong; Press, William H; Finkelstein, Ilya J.

Cell ; 170(1): 35-47.e13, 2017 Jun 29.

Artigo em Inglês | MEDLINE | ID: mdl-28666121

4.

Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.

Hu, Chunyi; Myers, Mason T; Zhou, Xufei; Hou, Zhonggang; Lozen, Macy L; Nam, Ki Hyun; Zhang, Yan; Ke, Ailong.

Mol Cell ; 84(3): 463-475.e5, 2024 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-38242128

5.

PIWI Takes a Giant Step.

Xiao, Yibei; Ke, Ailong.

Cell ; 167(2): 310-312, 2016 Oct 06.

Artigo em Inglês | MEDLINE | ID: mdl-27716504

6.

Multiple adaptations underly co-option of a CRISPR surveillance complex for RNA-guided DNA transposition.

Park, Jung-Un; Petassi, Michael T; Hsieh, Shan-Chi; Mehrotra, Eshan; Schuler, Gabriel; Budhathoki, Jagat; Truong, Vinh H; Thyme, Summer B; Ke, Ailong; Kellogg, Elizabeth H; Peters, Joseph E.

Mol Cell ; 83(11): 1827-1838.e6, 2023 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-37267904

7.

Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems.

Tan, Renke; Krueger, Ryan K; Gramelspacher, Max J; Zhou, Xufei; Xiao, Yibei; Ke, Ailong; Hou, Zhonggang; Zhang, Yan.

Mol Cell ; 82(4): 852-867.e5, 2022 02 17.

Artigo em Inglês | MEDLINE | ID: mdl-35051351

8.

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools.

Hu, Chunyi; Ni, Dongchun; Nam, Ki Hyun; Majumdar, Sonali; McLean, Justin; Stahlberg, Henning; Terns, Michael P; Ke, Ailong.

Mol Cell ; 82(15): 2754-2768.e5, 2022 08 04.

Artigo em Inglês | MEDLINE | ID: mdl-35835111

9.

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.

Hu, Chunyi; Almendros, Cristóbal; Nam, Ki Hyun; Costa, Ana Rita; Vink, Jochem N A; Haagsma, Anna C; Bagde, Saket R; Brouns, Stan J J; Ke, Ailong.

Nature ; 598(7881): 515-520, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34588691

10.

Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas.

Dolan, Adam E; Hou, Zhonggang; Xiao, Yibei; Gramelspacher, Max J; Heo, Jaewon; Howden, Sara E; Freddolino, Peter L; Ke, Ailong; Zhang, Yan.

Mol Cell ; 74(5): 936-950.e5, 2019 06 06.

Artigo em Inglês | MEDLINE | ID: mdl-30975459

11.

Building the Class 2 CRISPR-Cas Arsenal.

Lewis, Kevin M; Ke, Ailong.

Mol Cell ; 65(3): 377-379, 2017 Feb 02.

Artigo em Inglês | MEDLINE | ID: mdl-28157502

12.

How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.

Xiao, Yibei; Ng, Sherwin; Nam, Ki Hyun; Ke, Ailong.

Nature ; 550(7674): 137-141, 2017 10 05.

Artigo em Inglês | MEDLINE | ID: mdl-28869593

13.

Mn(2+)-sensing mechanisms of yybP-ykoY orphan riboswitches.

Price, Ian R; Gaballa, Ahmed; Ding, Fang; Helmann, John D; Ke, Ailong.

Mol Cell ; 57(6): 1110-1123, 2015 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-25794619

14.

Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.

Hayes, Robert P; Xiao, Yibei; Ding, Fran; van Erp, Paul B G; Rajashankar, Kanagalaghatta; Bailey, Scott; Wiedenheft, Blake; Ke, Ailong.

Nature ; 530(7591): 499-503, 2016 Feb 25.

Artigo em Inglês | MEDLINE | ID: mdl-26863189

15.

ATP/ADP modulates gp16-pRNA conformational change in the Phi29 DNA packaging motor.

Cai, Rujie; Price, Ian R; Ding, Fang; Wu, Feifei; Chen, Ting; Zhang, Yunlong; Liu, Guangfeng; Jardine, Paul J; Lu, Changrui; Ke, Ailong.

Nucleic Acids Res ; 47(18): 9818-9828, 2019 10 10.

Artigo em Inglês | MEDLINE | ID: mdl-31396619

16.

Structural basis for guanidine sensing by the ykkC family of riboswitches.

Battaglia, Robert A; Price, Ian R; Ke, Ailong.

RNA ; 23(4): 578-585, 2017 04.

Artigo em Inglês | MEDLINE | ID: mdl-28096518

17.

Functional characterization and crystal structure of thermostable amylase from Thermotoga petrophila, reveals high thermostability and an unusual form of dimerization.

Hameed, Uzma; Price, Ian; Ke, Ailong; Wilson, David B; Mirza, Osman.

Biochim Biophys Acta Proteins Proteom ; 1865(10): 1237-1245, 2017 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-28648523

18.

Identification of a conserved branched RNA structure that functions as a factor-independent terminator.

Johnson, Christopher M; Chen, Yuqing; Lee, Heejin; Ke, Ailong; Weaver, Keith E; Dunny, Gary M.

Proc Natl Acad Sci U S A ; 111(9): 3573-8, 2014 Mar 04.

Artigo em Inglês | MEDLINE | ID: mdl-24550474

19.

T box RNA decodes both the information content and geometry of tRNA to affect gene expression.

Grigg, Jason C; Chen, Yujie; Grundy, Frank J; Henkin, Tina M; Pollack, Lois; Ke, Ailong.

Proc Natl Acad Sci U S A ; 110(18): 7240-5, 2013 Apr 30.

Artigo em Inglês | MEDLINE | ID: mdl-23589841

20.

Common themes and differences in SAM recognition among SAM riboswitches.

Price, Ian R; Grigg, Jason C; Ke, Ailong.

Biochim Biophys Acta ; 1839(10): 931-938, 2014 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-24863160

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