Detalhe da pesquisa
1.
Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity.
J Pharmacol Exp Ther
; 354(2): 225-9, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26062557
2.
Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1.
Drug Metab Dispos
; 42(11): 1780-4, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25106415
3.
Investigational small-molecule drug selectively suppresses constitutive CYP2B6 activity at the gene transcription level: physiologically based pharmacokinetic model assessment of clinical drug interaction risk.
Drug Metab Dispos
; 42(6): 1008-15, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24658455
4.
Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.
Drug Metab Dispos
; 42(1): 182-92, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24194513
5.
Physiologically Based Pharmacokinetic Modeling and Allometric Scaling in Pediatric Drug Development: Where Do We Draw the Line?
J Clin Pharmacol
; 61 Suppl 1: S83-S93, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34185901
6.
Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone-Atomoxetine Interaction.
CPT Pharmacometrics Syst Pharmacol
; 9(2): 77-86, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31808613