Detalhe da pesquisa
1.
Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon.
Immunity
; 50(3): 591-599.e6, 2019 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30893587
2.
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
Cell
; 148(3): 421-33, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22304913
3.
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
Cell
; 147(1): 223-34, 2011 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21962518
4.
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases.
Med Res Rev
; 2024 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38279990
5.
Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 30(9): 127097, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32171616
6.
A novel hydroxycinnamoyl transferase for synthesis of hydroxycinnamoyl spermine conjugates in plants.
BMC Plant Biol
; 19(1): 261, 2019 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31208339
7.
Design, synthesis of novel purin-6-one derivatives as phosphodiesterase 2 (PDE2) inhibitors: The neuroprotective and anxiolytic-like effects.
Bioorg Med Chem Lett
; 29(3): 481-486, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30554955
8.
Crystal Structures of Candida albicans Phosphodiesterase 2 and Implications for Its Biological Functions.
Biochemistry
; 57(42): 6070-6077, 2018 10 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30231198
9.
Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors.
Biochemistry
; 57(30): 4518-4525, 2018 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29975048
10.
The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.
J Biol Chem
; 290(20): 12941-50, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25809483
11.
Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor.
Mol Pharmacol
; 88(5): 836-45, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26316540
12.
Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate.
Biochemistry
; 53(30): 4938-45, 2014 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050706
13.
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
J Biol Chem
; 287(15): 11788-97, 2012 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22356915
14.
A potential substrate binding conformation of ß-lactams and insight into the broad spectrum of NDM-1 activity.
Antimicrob Agents Chemother
; 56(10): 5157-63, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22825119
15.
Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain.
J Biol Chem
; 285(49): 38149-56, 2010 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20861010
16.
Structural insight into the substrate specificity of phosphodiesterases.
Handb Exp Pharmacol
; (204): 121-34, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21695637
17.
Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds.
Handb Exp Pharmacol
; (200): 93-133, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-20859794
18.
Therapeutic potential of phosphodiesterase inhibitors in parasitic diseases.
Handb Exp Pharmacol
; (204): 487-510, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21695653
19.
Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E.
Biochemistry
; 49(43): 9280-91, 2010 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20839809
20.
Computer-based redesign of a beta sandwich protein suggests that extensive negative design is not required for de novo beta sheet design.
Structure
; 16(12): 1799-805, 2008 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19081056