Detalhe da pesquisa
1.
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
Proc Natl Acad Sci U S A
; 118(13)2021 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753481
2.
Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone.
Bioorg Chem
; 128: 105905, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35710525
3.
Discovery of M Protease Inhibitors Encoded by SARS-CoV-2.
Antimicrob Agents Chemother
; 64(9)2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32669265
4.
Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology.
Med Res Rev
; 38(4): 1188-1234, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28768055
5.
Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers.
Biochim Biophys Acta Proteins Proteom
; 1865(3): 336-343, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-28012872
6.
Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity.
J Comput Aided Mol Des
; 29(1): 89-100, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25344840
7.
The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling.
J Biol Chem
; 288(24): 17689-97, 2013 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23629653
8.
Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus.
Mol Cancer Ther
; 23(6): 766-779, 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38592383
9.
Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease.
Eur J Med Chem
; 258: 115583, 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37393792
10.
Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway.
J Virol
; 85(17): 9114-26, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21697490
11.
Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation.
Eur J Med Chem
; 243: 114728, 2022 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36084534
12.
The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling.
J Biol Chem
; 290(19): 11935, 2015 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25957413
13.
Characterization of a mutated KCNJ5 gene, G387R, in unilateral primary aldosteronism.
J Mol Endocrinol
; 67(4): 203-215, 2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34463641
14.
Chemoproteomic profiling reveals cellular targets of nitro-fatty acids.
Redox Biol
; 46: 102126, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34509914
15.
Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.
J Med Chem
; 64(11): 7312-7330, 2021 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34009981
16.
Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery.
Sci Rep
; 10(1): 16771, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33033310
17.
Repurposing old drugs as antiviral agents for coronaviruses.
Biomed J
; 43(4): 368-374, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32563698
18.
Artificial intelligence approach fighting COVID-19 with repurposing drugs.
Biomed J
; 43(4): 355-362, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32426387
19.
Dual Kit/Aur Inhibitors as Chemosensitizing Agents for the Treatment of Melanoma: Design, Synthesis, Docking Studies and Functional Investigation.
Sci Rep
; 9(1): 9943, 2019 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31289333
20.
The in vivo antinociceptive and µ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone.
Eur J Med Chem
; 167: 312-323, 2019 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30776693