1.
Infect Immun
; 71(7): 4190-2, 2003 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12819116
RESUMO
The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.