1.
Angew Chem Int Ed Engl
; 61(28): e202204884, 2022 07 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35608327
RESUMO
A highly convergent total synthesis of (-)-bastimolideâ A (1), a polyhydroxy antimalarial macrolide, has been achieved via a longest linear sequence of twenty steps from commercially available glycidyl ethers. Type I Anion Relay Chemistry (ARC) coupling tactics enable rapid construction of the molecule's 1,5-polylol backbone. A late-stage B-alkyl Suzuki-Miyaura union and an Evans-modified Mukaiyama macrolactonization generate the forty-membered Z-α,ß-unsaturated macrocyclic lactone.