Type III DNA restriction and modification systems EcoP1 and EcoP15. Nucleotide sequence of the EcoP1 operon, the EcoP15 mod gene and some EcoP1 mod mutants.

This paper presents the nucleotide sequence of the mod-res operon of phage P1, which encodes the two structural genes for the EcoP1 type III restriction and modification system. We have also sequenced the mod gene of the allelic EcoP15 system. The mod gene product is responsible for binding the system-specific DNA recognition sequences in both restriction and modification; it also catalyses the modification reaction. A comparison of the two mod gene product sequences shows that they have conserved amino and carboxyl ends but have completely different sequences in the middle of the molecules. Two alleles of the EcoP1 mod gene that are defective in modification but not in restriction were also sequenced. The mutations in both alleles lie within the non-conserved regions.

The birth and death of religious leaders.

The phenomenon of religious leadership is a complex one. This article proposes that Ernest Becker's insight into the human tendency to deny death contributes to a better understanding of both the psychological and sociological dimensions of religious leadership. Specifically, it examines the role of transference in the leader-follower relationship and probes how this mechanism promotes the birth and demise of religious leaders. Some practical suggestions for healthy leader-follower relations are offered.