[Bilateral inverted papilloma originating from the frontal sinus]. / Iki tarafli frontal sinüs kaynakli inverted papillom.

Inverted papilloma is a benign neoplasm characterized by its high rate of recurrence, local aggressiveness, and malignancy potential. Nasal obstruction is the most frequent presenting complaint. Bilateral inverted papillom involving both sides of the frontal sinus is extremely rare. Herein, we present a 64-year-old male case with a bilateral inverted papilloma involving the frontal sinus which was removed by an endoscopic surgery.

[Endoscopic management of cerebrospinal fluid fistulas and clinic outcomes]. / Beyin omurilik sivisi fistüllerine endoskopik yaklasim ve klinik sonuçlari

OBJECTIVES: This study aims to evaluate the efficacy of endoscopic repair of cerebrospinal fluid (CSF) fistulas. PATIENTS AND METHODS: Between January 2005 and December 2012, 10 patients (7 females, 3 males; mean age 36.1 years; range 1 to 52 years) who were diagnosed with CSF fistulas in Kocaeli University, Faculty of Medicine, Ear Nose and Throat Clinic were retrospectively analyzed. Complaints of the patients on admission and the characteristics of CSF fistulas (etiology, location, and stage) were recorded. Treatment modalities based on the characteristics of CSF fistulas and treatment outcomes were analyzed. RESULTS: The etiology of the fistula was encephalocele in six, iatrogenic trauma following functional endoscopic sinus surgery (FESS) in three, and spontaneous CSF rhinorrhea in one patient. The mean follow-up was 32.4 months (range, 12 to 84 months) postoperatively. None of the patients had recurrent disease. CONCLUSION: The endoscopic surgery is an effective modality with low morbidity and high success rate in the management of CSF fistulas.

Comparison of growth curve models in partridge.

This study was conducted in order to determine the goodness of fit of Brody, Gompertz, Logistic, and von Bertalanffy growth curve models in partridge (Alectoris chukar). The growth curve parameters A (upper asymptote or mature weight parameter), B (scale parameter related to initial weight), and K (instantaneous growth rate parameter) were determined as 623.4, 1.05, and 0.075 for females and 723.8, 1.06, and 0.073 for males in the Brody model, respectively, 472.9, 3.47, and 0.207 for females and 565.3, 3.59, and 0.192 for males in the Gompertz model, respectively, 440.2, 12.89, and 0.332 for females and 517.0, 14.13, and 0.319 for males in the Logistic model, respectively, and 498.9, 0.77, and 0.164 for females and 608.8, 0.79, and 0.150 for males in the von Bertalanffy model, respectively. While determining which growth curve model presented the better fit, the coefficient of determination (R2), adjusted the coefficient of determination (adj.R2), mean square predicted error (MSPE), Durbin-Watson value, correlation between estimated live weight and residual values (RESC), Akaike's information criteria (AIC), and Bayesian information criterion (BIC) were used. As a consequence of the study, it was determined that the Gompertz model yields a better fit to the data for the partridge, as its coefficient of determination and adjusted coefficient of determination are high, its values of MSPE, RESC, AIC, BIC are low and there is not an autocorrelation between the residual values. As a result, the Gompertz model presented a better fit with the partridge data.

Effect of caffeic acid phenethyl ester on oxidant and anti-oxidant status of liver and serum in a rat model with acute methanol intoxication.

BACKGROUND: Methanol toxicity is one of the major public health problems because it can cause severe morbidity and mortality. Methanol intoxication causes changes in the balance between the production of free radicals and antioxidant capacity. AIMS: We aimed to investigate the effects of caffeic acid phenethyl ester (CAPE) on the total oxidant status, total antioxidant status (TAS), and oxidative stress index (OSI) parameters of the liver and the serum in a rat model of acute methanol intoxication. MATERIALS AND METHODS: Rats were treated with intraperitoneal (i.p.) Methotrexate (MTX) for 7 days. On the 8th day, i.p. Methanol was administered in the methanol, ethanol and CAPE groups. Four hours after methanol treatment, ethanol was injected i.p. in the ethanol group; CAPE (i.p.) in the CAPE group; serum physiologic i.p. in other groups. After 8 hours, rats were killed and the serum and the liver samples were obtained for biochemical analyses. RESULTS: The OSI value was significantly higher in the methanol group compared to the ethanol and CAPE groups. Serum TAS levels of the methanol group were significantly different compared to the control group, but not compared to the MTX group. The amelioration of oxidative stress was greater in the CAPE group compared to the ethanol group but was not statistically significant. CONCLUSION: This study demonstrates that CAPE treatment ameliorates oxidative stress in the serum and liver in a rat model of acute methanol intoxication.

Effects of Foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing.

We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and limonene were applied topically to the wounds once daily, separately or together, for 10 days. Tissue sections from the wounds were evaluated for histopathology. The healing potential was assessed by comparison to an untreated control group and an olive oil treated sham group. We scored wound healing based on epidermal regeneration, granulation tissue thickness and angiogenesis. After day 6, wound contraction with limonene was significantly better than for the control group. Ten days after treatment, a significant increase was observed in wound contraction and re-epithelialization in both fenchone and limonene oil treated groups compared to the sham group. Groups treated with fenchone and with fenchone + limonene scored significantly higher than the control group, but the difference was not statistically significant compared to the olive oil treated group. Our findings support the beneficial effects of fenchone and limonene for augmenting wound healing. The anti-inflammatory and antimicrobial activities of fenchone and limonene oil increased collagen synthesis and decreased the number of inflammatory cells during wound healing and may be useful for treating skin wounds.

Paranasal sinus mucoceles: our clinical experiments.

OBJECTIVES: We present the clinical and radiological features, treatment protocols, and medium-long-term results of our patients following surgery for paranasal sinus mucocele, along with a review of the relevant literature. MATERIALS AND METHODS: A total of 18 patients (11 women and 7 men) who underwent surgery for paranasal sinus mucocele at Kocaeli University Faculty of Medicine, Department of Otolaryngology, between 2006 and 2013 were examined retrospectively. The mean patient age was 41 (range 4-73). Demographic and radiological features, symptoms, treatment protocols, and postoperative outcomes were recorded. RESULTS: The most frequently affected sinus was the maxillary sinus (n=9, 50%) followed by the frontal sinus (n=6, 33%) and sphenoidal sinus (n=3, 16%). The main symptom was headache. Endoscopic marsupialization of the mucocele was applied in all 18 patients, while frontal sinus exploration with the osteoplastic flap procedure was performed in one patient and the Caldwell-Luc operation was performed in another patient. The Caldwell-Luc procedure was subsequently required in one patient (6%) and endoscopic revision surgery was required in another patient (6%). CONCLUSION: Sinus mucocele that enlarges, eroding the surrounding bone tissue, and induces various clinical symptoms due to the impression of the expansile mass, is treated surgically, and must be planned carefully to prevent serious complications.

Ethmoid roof radiology; analysis of lateral lamella of cribriform plate.

OBJECTIVE: We evaluated the extent of asymmetry evident in paranasal sinus computed tomography (CT) scans of Turkish patients without sinusitis in the ethmoid roof. Our data contribute to the body of knowledge on the subject. MATERIALS AND METHODS: We retrospectively studied multiplanar reformatted CT images of the paranasal sinus (1-mm sections) from 110 patients (50 male, 60 female). Ethmoid roof variations on either side were compared and the lateral lamellar length of the cribriform plate was measured. The results were scored using the Keros classification. RESULTS: The lateral lamella of the cribriform plate averaged 5.78 mm in height on the right side and 5.98 mm on the left. The most common Keros type was type 2 (67.72%), followed by type 3 (22.28%), and type 1 (10%). Keros asymmetry (≥ 0.01 mm, affecting either side) was apparent in all patients (48.2% right-sided and 51.8% left-sided). RESULTS: Preoperatively, paranasal sinus CT scans should be evaluated carefully to eliminate the possibility of life-threatening complications, including intracranial trauma, which may develop during endoscopic sinus surgery; the left and right sides of the ethmoid roof may differ in depth.

Parotid gland tumours in Turkish population: analysis of 165 patients.

BACKGROUND: Retrospective data on 165 patients who presented with a parotid mass and underwent surgery in our clinics during 2000-2009 were examined. The obtained data (demographic data, surgical procedures, histopathological diagnoses) were compared to similar studies to make contributions to the literature. MATERIALS AND METHODS: Patients were classified according to their histopathological diagnosis. Surgical procedures and patient follow-up were clarified. The results are presented as means and standard deviations. RESULTS: Of the 165 masses, 134 (81.3%) were benign and 31 (18.7%) were malignant. Pleomorphic adenoma was the most common benign tumour (79 patients, 59%). Lymphoma and adenoid cystic carcinoma were equally common and were the most common malignant parotid gland tumours (both 6 patients, 19.3%). The most frequent surgical procedure was superficial parotidectomy (92 patients, 55.7%), and the most commonly encountered surgical complication was facial paralysis (12 patients, 7.2%). CONCLUSIONS: Our data are generally in line with the literature but lymphoma was more common than in most previous reports. Although the number of cases was low, the high incidence of parotid gland lymphoma was remarkable.

Surgical and audiological evaluation of the Baha BA400.

OBJECTIVE: Despite extensive soft tissue reduction, the most common complications associated with bone-anchored hearing aid systems, also known as bone-anchored hearing implants, are related to adverse skin reactions around the abutment. The necessary soft tissue reduction also adds complexity to the surgical procedure. This study aimed to evaluate the surgical and audiological outcomes of a new connective interface of the Cochlear™ Baha® BA400 device implanted using the one-stage surgical technique. METHOD: A multicentre, retrospective case series is presented, including data collected from three tertiary care institutions. RESULTS: In total, 16 patients who had undergone bone-anchored hearing aid surgery over a 10- to 12-month period were assessed for hearing performance, implant stability and surgical complications. CONCLUSION: This case series indicates that new abutments with a hydroxyapatite coating can be implanted percutaneously without soft tissue reduction. Furthermore, device implantation using this surgical technique may have some advantages compared with a conventional device and procedure combination over 12- to 16-months of follow up.

Tracheal reconstruction using alcohol-stored homologous cartilage and autologous cartilage in the rabbit model.

OBJECTIVE: Reconstruction of laryngotracheal stenosis continues to pose a significant challenge. Cartilage grafts have been in use for almost a century, but despite good clinical results, many questions concerning the survival and growth of implanted cartilage persist. To reduce donor site morbidity, the use of homologous cartilage has been investigated. This study compared alcohol-stored homologous auricular cartilage with autologous auricular cartilage for anterior graft laryngotracheal reconstruction in a rabbit model. METHODS: Autologous and alcohol preserved homologous auricular cartilage was transplanted to the resected anterior tracheal wall of the twenty New Zealand rabbits. Rabbits were sacrificed 6 weeks after surgery and histologic analysis was performed on the implanted cartilage grafts. RESULTS: The autografts were significantly more likely than the homografts to demonstrate viable cells (95% vs. 30%, P<0.05) and less likely to exhibit significant resorption, fibrosis or necrosis (P<0.05). Resorption and necrosis were most common in areas of trauma to the graft. Complete epithelialization occurred in all of the autografts but in only 65% of the homografts (P<0.05). New cartilage formation and integration of the implanted grafts was poor with both types of grafts. CONCLUSION: Autologous cartilage appears to have better survival than alcohol preserved homologous cartilage when used for anterior graft laryngotracheal reconstruction in a rabbit model.

Effectiveness of hyperbaric oxygen therapy in the treatment of complex regional pain syndrome.

In this double-blind, randomized, placebo-controlled study we aimed to assess the effectiveness of hyperbaric oxygen (HBO) therapy for treating patients with complex regional pain syndrome (CRPS). Of the 71 patients, 37 were allocated to the HBO group and 34 to the control (normal air) group. Both groups received 15 therapy sessions in a hyperbaric chamber. Pain, oedema and range of motion (ROM) of the wrist were evaluated before treatment, after the 15th treatment session and on day 45. In the HBO group there was a significant decrease in pain and oedema and a significant increase in the ROM of the wrist. When we compared the two groups, the HBO group had significantly better results with the exception of wrist extension. In conclusion, HBO is an effective and well-tolerated method for decreasing pain and oedema and increasing the ROM in patients with CRPS.

A new treatment modality for fibromyalgia syndrome: hyperbaric oxygen therapy.

Fibromyalgia syndrome (FMS) is characterized by longstanding multifocal pain with generalized allodynia/hyperalgesia. There are several treatment methods but none has been specifically approved for this application. We conducted a randomized controlled study to evaluate the effect of hyperbaric oxygen (HBO) therapy in FMS (HBO group: n = 26; control group: n = 24). Tender points and pain threshold were assessed before, and after the first and fifteenth sessions of therapy. Pain was also scored on a visual analogue scale (VAS). There was a significant reduction in tender points and VAS scores and a significant increase in pain threshold of the HBO group after the first and fifteenth therapy sessions. There was also a significant difference between the HBO and control groups for all parameters except the VAS scores after the first session. We conclude that HBO therapy has an important role in managing FMS.

Pneumatization of the inferior turbinate.

Pneumatization of the inferior turbinate is an extremely rare intranasal anatomical variation. Only a few cases have been reported yet. In this paper we present two cases, one unilateral and one bilateral case with pneumatization of the inferior turbinate.